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Genotoxicity, acute and subchronic toxicity studies of nano liposomes of Orthosiphon stamineus ethanolic extract in Sprague Dawley rats

Shafaei A 1 , Esmailli K 1 , Farsi E 2 , Aisha AF 1 , Abul Majid AM 2 , Ismail Z 3

Affiliations 

  • 1 Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, 11800, Malaysia
  • 2 Department of Pharmacology, School of Pharmaceutical Sciences, EMAN Testing & Research Laboratory, Universiti Sains Malaysia, Minden, Penang, 11800, Malaysia
  • 3 Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, 11800, Malaysia. [email protected]
BMC Complement Altern Med, 2015;15:360.
PMID: 26467526 DOI: 10.1186/s12906-015-0885-z

Abstract

Orthosiphon stamineus (OS) Benth is a medicinal plant and native in Southeast Asia. Pharmacological effects of OS are attributed to the presence of lipophilic flavones. However; lipophilic compounds suffer from poor aqueous solubility which limits the OS oral bioavailability and therapeutic applications. Therefore, OS was prepared in nano formulation form using liposomes from soybean phospholipids. The aim of the present study is to evaluate the in vitro genotoxicity and in vivo oral toxicity of nano liposomes of OS ethanolic extract (OS-EL).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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