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Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity

Lin RC 1 , Ng SF 2 , Morris MJ 3

Affiliations 

  • 1 Asbestos Diseases Research Institute, NSW, 2139 Sydney, Australia ; School of Biotechnology and Biomolecular Sciences, University of New South Wales, NSW 2052, Australia
  • 2 Department of Paediatrics, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Universiti Kebangsaan Malaysia, 56000 Kuala Lumpur, Malaysia ; Department of Pharmacology, School of Medical Sciences, University New South Wales, NSW 2052, Australia
  • 3 Department of Pharmacology, School of Medical Sciences, University New South Wales, NSW 2052, Australia
Genom Data, 2014 Dec;2:351-3.
PMID: 26484128 DOI: 10.1016/j.gdata.2014.09.013

Abstract

Paternal high fat diet (HFD) consumption triggers unique gene signatures, consistent with premature aging and chronic degenerative disorders, in both white adipose tissue (RpWAT) and pancreatic islets of daughters. In addition to published data in Nature, 2010, 467, 963-966 (GSE: 19877, islet) and FASEB J 2014, 28, 1830-1841 (GSE: 33551, RpWAT), we describe here additional details on systems-based approaches and analysis to develop our observations. Our data provides a resource for exploring the complex molecular mechanisms that underlie intergenerational transmission of obesity.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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