A Self-Assembled Metallomacrocycle Singlet Oxygen Sensitizer for Photodynamic Therapy

Walker MG 1 , Jarman PJ 1 , Gill MR 2 , Tian X 3 , Ahmad H 4 , Reddy PA 1 Show all authors , McKenzie L 1 , Weinstein JA 1 , Meijer AJ 1 , Battaglia G 3 , Smythe CG 5 , Thomas JA 6

Affiliations 

  • 1 Department of Chemistry, University of Sheffield, Sheffield, S10 3GZ, UK
  • 2 Department of Biomedical Science, University of Sheffield, Sheffield, UK
  • 3 Department of Chemistry, University College London, London, UK
  • 4 Department of Chemistry, Universiti Putra Malaysia, 43400 UPM, Serdang, Malaysia
  • 5 Department of Biomedical Science, University of Sheffield, Sheffield, UK. [email protected]
  • 6 Department of Chemistry, University of Sheffield, Sheffield, S10 3GZ, UK. [email protected]
Chemistry, 2016 Apr 18;22(17):5996-6000.
PMID: 27000412 DOI: 10.1002/chem.201600852

Abstract

Although metal-ion-directed self-assembly has been widely used to construct a vast number of macrocycles and cages, it is only recently that the biological properties of these systems have begun to be explored. However, up until now, none of these studies have involved intrinsically photoexcitable self-assembled structures. Herein we report the first metallomacrocycle that functions as an intracellular singlet oxygen sensitizer. Not only does this Ru2 Re2 system possess potent photocytotoxicity at light fluences below those used for current medically employed systems, it offers an entirely new paradigm for the construction of sensitizers for photodynamic therapy.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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