Comparative evaluation of the degree of pegylation of poly(lactic-co-glycolic acid) nanoparticles in enhancing central nervous system delivery of loperamide

Kirby BP 1 , Pabari R , Chen CN , Al Baharna M , Walsh J , Ramtoola Z

Affiliations 

  • 1 School of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland; Department of Pharmacology, PU-RCSI School of Medicine, Perdana University, Selangor, Malaysia
J Pharm Pharmacol, 2013 Oct;65(10):1473-81.
PMID: 24028614 DOI: 10.1111/jphp.12125

Abstract

In this study, we examined the relative cellular uptake of nanoparticles (NPs) formulated using poly(lactic-co-glycolic acid) (PLGA) polymers with increasing degree of pegylation (PLGA-PEG) and their potential to deliver loperamide to the brain of a mouse.

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