Multi-omics reveal toxicity mechanisms underpinning nanoplastic in redclaw crayfish (Cherax quadricarinatus)

Zhu T 1 , Yao C 2 , Hong S 3 , Song W 2 , Zanuri NM 1 , Lv W 4 Show all authors , Jiang Q 5

Affiliations 

  • 1 Centre for Marine and Coastal Studies, Universiti Sains Malaysia, Minden, Penang 11700, Malaysia
  • 2 Institute for Agri-food Standards and Testing Technology, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China
  • 3 Institute for Agri-food Standards and Testing Technology, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China; College of Fisheries and Life Science, Shanghai Ocean University, Shanghai 201306, China
  • 4 Eco-environmental Protection Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China. Electronic address: [email protected]
  • 5 Freshwater Fisheries Research Institute of Jiangsu Province, No. 79 Chating East Rd, Nanjing 210017, China. Electronic address: [email protected]
Sci Total Environ, 2024 Nov 15;951:175680.
PMID: 39173758 DOI: 10.1016/j.scitotenv.2024.175680

Abstract

We investigated the effects of different nanoplastic (NP, size = 100 nm) concentrations on red crayfish (Cherax quadricarinatus) and examined toxicity mechanisms. We established four concentration groups (control (CK): 0 μg/L; Low: 100 μg/L; Medium: 500 μg/L; and High: 1000 μg/L) and analyzed toxicity effects in C. quadricarinatus hepatopancreas using histopathological, transcriptomic, metabolomic, and fluorescence methods. NP exposure caused histological lesions and oxidative stress in hepatopancreas, and also significantly decreased glutathione (GSH) (P 

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