Stimulatory effect of eurycomanone from Eurycoma longifolia Jack roots on dopamine secretion in human neuroblastoma SH-SY5Y cell line

Ang JJ 1 , Shivashekaregowda NKH 2 , Yow HY 3 , Rizwan F 1 , Wong PF 4 , Jantan I 5 Show all authors , Omar MH 6 , Misnan NM 6 , Low BS 1

Affiliations 

  • 1 Faculty of Health and Medical Sciences, School of Medicine, Taylor's University, Selangor, Malaysia
  • 2 Faculty of Health and Medical Sciences, School of Pharmacy, Taylor's University, Selangor, Malaysia
  • 3 Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur, Malaysia
  • 4 Department of Pharmacology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia
  • 5 Institut Biologi Sistem, Universiti Kebangsaan Malaysia, Selangor, Malaysia
  • 6 Photochemistry Unit, Herbal Medicine Research Centre, Institute of Medical Research, National Institutes of Health, Selangor, Malaysia
Nat Prod Res, 2024 Jul 27.
PMID: 39066784 DOI: 10.1080/14786419.2024.2383272

Abstract

Eurycomanone has been identified as the major bioactive compound contributing to Eurycoma longifolia (EL) aphrodisiac activity, however, its mechanism of action remains obscured. Presently, eurycomanone was isolated from EL root extract and its molecular structure was identified. The human neuroblastoma SH-SY5Y cell line was differentiated into human dopaminergic neuron-like cells. Exogenous dopamine levels from the differentiated SH-SY5Y cells were quantified following the treatment of 5, 10, 15 μM of eurycomanone and 10 μM clorgyline as positive control. Dopamine secretion was significantly increased in a dose-dependent manner, compared to the vehicle control (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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