Protective effects of feed additives on broiler chickens exposed to aflatoxins-contaminated feed: a systematic review and meta-analysis

Putra RP 1 , Astuti D 2 , Respati AN 3 , Ningsih N 3 , Triswanto 4 , Yano AA 5 Show all authors , Gading BMWT 6 , Jayanegara A 7 , Sholikin MM 8 , Hassim HA 9 , Azmi AFM 9 , Adli DN 10 , Irawan A 11

Affiliations 

  • 1 Department of Agriculture and Horticulture, Province of Jambi, Jambi, 36122, Indonesia
  • 2 Agrotechnology Innovation Center, Universitas Gadjah Mada, Sleman, 55573, Indonesia
  • 3 Department of Animal Science, Politeknik Negeri Jember, Jember, 68101, Indonesia
  • 4 Department of Feed Technology, PT. Charoen Pokphand Indonesia, Jakarta Utara, 14350, Indonesia
  • 5 Vocational School, Universitas Sebelas Maret, Surakarta, 57126, Indonesia
  • 6 Department of Animal Science, Universitas Sulawesi Barat, Majene, Indonesia
  • 7 Department of Nutrition and Feed Technology, Faculty of Animal Science, IPB University, Bogor, 16680, Indonesia
  • 8 Animal Feed and Nutrition Modelling (AFENUE) Research Group, Faculty of Animal Science, IPB University, Bogor, 16680, Indonesia
  • 9 Department of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Institute of Tropical Agriculture and Food Security Universiti Putra Malaysia (UPM), Serdang, Selangor, 43400, Malaysia
  • 10 Faculty of Animal Science, Universitas Brawijaya, Malang, 65145, Indonesia
  • 11 Vocational School, Universitas Sebelas Maret, Surakarta, 57126, Indonesia. [email protected]
Vet Res Commun, 2024 Feb;48(1):225-244.
PMID: 37644237 DOI: 10.1007/s11259-023-10199-7

Abstract

Aflatoxin contamination in feed is a common problem in broiler chickens. The present systematic review and meta-analysis examined the impact of aflatoxin-contaminated feed and the efficacy of various feed additives on the production performance of broiler chickens fed aflatoxin-contaminated feed (AF-feed). A total of 35 studies comprising 53 AF-feed experiments were selected following PRISMA guidelines. Feed additives included in the analyses were toxins binder (TB), mannan-oligosaccharides (MOS), organic acid (OA), probiotics (PRO), protein supplementation (PROT), phytobiotics (PHY), and additive mixture (MIX). Random effects model and a frequentist network meta-analysis (NMA) were performed to rank the efficacy of feed additives, reported as standardized means difference (SMD) at 95% confidence intervals (95% CI). Overall, broiler chickens fed AF-feed had significantly lower final body weight (BW) (SMD = 198; 95% CI = 198 to 238) and higher feed conversion ratio (SMD = 0.17; 95% CI = 0.13 to 0.21) than control. Treatments with TB, MOS, and PHY improved the BW of birds fed AF-feed (P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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