A systematic review and meta-analysis of the omega-3 fatty acids effects on brain-derived neurotrophic factor (BDNF)

Ziaei S 1 , Mohammadi S 2 , Hasani M 3 , Morvaridi M 4 , Belančić A 5 , Daneshzad E 6 Show all authors , Saleh SAK 7 , Adly HM 8 , Heshmati J 9

Affiliations 

  • 1 ICU Department, Emam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • 2 Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 3 Department of Nutritional Sciences, School of Health, Golestan University of Medical Sciences, Gorgan, Iran
  • 4 Department of Nutrition Sciences, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  • 5 Department of Clinical Pharmacology, Clinical Hospital Centre Rijeka, Rijeka, Croatia
  • 6 Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  • 7 Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia
  • 8 Department of Community Medicine and Pilgrims Healthcare, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia
  • 9 Songhor Healthcare Center, Kermanshah University of Medical Sciences, Kermanshah, Songhor, Iran
Nutr Neurosci, 2023 Aug 17.
PMID: 37589276 DOI: 10.1080/1028415X.2023.2245996

Abstract

BACKGROUND: Omega-3 fatty acids (omega-3 FAs) have attracted the attention of researchers because of their influence on circulatory levels of brain-derived neurotrophic factor (BDNF). Our objective was to review systematically and Meta-analyze randomized controlled trials (RCTs) to assess the effects of omega-3 FAs supplementation on serum BDNF concentration.

METHODS: Scopus, PubMed, Web of Science, and Cochrane Library were systematically searched until April 2023. The Cochrane risk of bias assessment tool was utilized to evaluate the quality of the studies. A random-effects model was employed to estimate the overall effect size of BDNF levels, using the Standard Mean Difference (SMD) and a 95% confidence interval (CI). The heterogeneity among the studies was assessed using chi-squared and I2 statistics.

RESULTS: A total of 12 studies involving 587 subjects were included. The supplementation of PUFA was found to be associated with a significant increase in serum levels of BNDF in the group receiving the supplements, as compared to the placebo group (SMD: 0.72 pg/mL, 95% CI: 0.28, 1.15; P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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