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Anticancer properties and mechanism insights of α-hederin

Belmehdi O 1 , Taha D 2 , Abrini J 3 , Ming LC 4 , Khalid A 5 , Abdalla AN 6 Show all authors , Algarni AS 7 , Hermansyah A 8 , Bouyahya A 9

Affiliations 

  • 1 Biotechnology and Applied Microbiology Team, Department of Biology, Faculty of Sciences, Abdelmalek Essaadi University, Tetouan, Morocco. Electronic address: [email protected]
  • 2 Laboratory of Spectroscopy, Molecular Modelling Materials, Nanomaterials Water and Environment-CERNE2D, Faculty of Sciences, Mohammed V University in Rabat, Morocco. Electronic address: [email protected]
  • 3 Biotechnology and Applied Microbiology Team, Department of Biology, Faculty of Sciences, Abdelmalek Essaadi University, Tetouan, Morocco. Electronic address: [email protected]
  • 4 Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia; PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, BE1410 Gadong, Brunei Darussalam; School of Medical and Life Sciences, Sunway University, Sunway City 47500, Malaysia. Electronic address: [email protected]
  • 5 Substance Abuse and Toxicology Research Center, Jazan University, P.O. Box: 114, Jazan 45142, Saudi Arabia; Medicinal and Aromatic Plants and Traditional Medicine Research Institute, National Center for Research, P. O. Box 2404, Khartoum, the Sudan. Electronic address: [email protected]
  • 6 Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah , Saudi Arabia. Electronic address: [email protected]
  • 7 Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah , Saudi Arabia. Electronic address: [email protected]
  • 8 Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia. Electronic address: [email protected]
  • 9 Laboratory of Human Pathologies Biology, Faculty of Sciences, Mohammed V University in Rabat, Morocco. Electronic address: [email protected]
Biomed Pharmacother, 2023 Sep;165:115205.
PMID: 37499451 DOI: 10.1016/j.biopha.2023.115205

Abstract

α-Hederin is a natural bioactive molecule very abundant in aromatic and medicinal plants (AMP). It was identified, characterized, and isolated using different extraction and characterization technologies, such as HPLC, LC-MS and NMR. Biological tests have revealed that this natural molecule possesses different biological properties, particularly anticancer activity. Indeed, this activity has been investigated against several cancers (e.g., esophageal, hepatic, breast, colon, colorectal, lung, ovarian, and gastric). The underlying mechanisms are varied and include induction of apoptosis and cell cycle arrest, reduction of ATP generation, as well as inhibition of autophagy, cell proliferation, invasion, and metastasis. In fact, these anticancer mechanisms are considered the most targeted for new chemotherapeutic agents' development. In the light of all these data, α-hederin could be a very interesting candidate as an anticancer drug for chemotherapy, as well as it could be used in combination with other molecules already validated or possibly investigated as an agent sensitizing tumor cells to chemotherapeutic treatments.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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