Prevalence of sleep disturbance in patients with ankylosing spondylitis: a systematic review and meta-analysis

Salari N 1 , Sadeghi N 2 , Hosseinian-Far A 3 , Hasheminezhad R 4 , Khazaie H 4 , Shohaimi S 5 Show all authors , Mohammadi M 6

Affiliations 

  • 1 Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • 2 Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • 3 Department of Business Systems & Operations, University of Northampton, Northampton, UK
  • 4 Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • 5 Department of Biology, Faculty of Science, University Putra Malaysia, Serdang, Selangor, Malaysia
  • 6 Cellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash, Iran. [email protected]
Adv Rheumatol, 2023 Jul 19;63(1):33.
PMID: 37468951 DOI: 10.1186/s42358-023-00315-1

Abstract

BACKGROUND: Ankylosing Spondylitis (AS) patients face several challenges due to the nature of the disease and its physical and psychological complications. Sleep disorders are among the most important concerns. Sleep disorders can aggravate the signs and symptoms of the disease and ultimately reduce the quality of patients' lives. This study uses a systematic review and meta-analysis to pool the reported prevalence of sleep disorders among AS patients.

METHODS: To find related studies, the WoS, PubMed, ScienceDirect, Scopus, Embase, and Google Scholar databases were systematically searched without a lower time limit. Heterogeneity among the identified studies was checked using the I2 index, and the Begg and Mazumdar correlation test examined the existence of published bias. Comprehensive Meta-Analysis (v.2) software was adopted to analyze the data.

RESULTS: In the review of 18 studies with a sample size of 5,840, the overall pooled prevalence of sleep disorders among AS patients based on the random effects method was found to be 53% (95% CI: 44.9-61). The highest and lowest prevalence was in Egypt at 90% and Australia at 19.2%, respectively. Our meta-regression results show that with the increase in 'sample size' and 'year of publication', the overall prevalence of sleep disorders in patients with AS decreases (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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