Affiliations 

  • 1 Institute for Medical Research (IMR), National Institutes of Health (NIH), Ministry of Health Malaysia, 40170, Setia Alam, Malaysia
  • 2 Institute for Medical Research (IMR), National Institutes of Health (NIH), Ministry of Health Malaysia, 40170, Setia Alam, Malaysia. [email protected]
  • 3 Ministry of Health Malaysia, 62590, Putrajaya, Malaysia
  • 4 Heriot-Watt University Malaysia, 62200, Putrajaya, Malaysia
Sci Rep, 2022 02 09;12(1):2197.
PMID: 35140319 DOI: 10.1038/s41598-022-06341-1

Abstract

This paper aims to develop an automated web application to generate validated daily effective reproduction numbers (Rt) which can be used to examine the effects of super-spreading events due to mass gatherings and the effectiveness of the various Movement Control Order (MCO) stringency levels on the outbreak progression of COVID-19 in Malaysia. The effective reproduction number, Rt, was estimated by adopting and modifying an Rt estimation algorithm using a validated distribution mean of 3.96 and standard deviation of 4.75 with a seven-day sliding window. The Rt values generated were validated using thea moving window SEIR model with a negative binomial likelihood fitted using methods from the Bayesian inferential framework. A Pearson's correlation between the Rt values estimated by the algorithm and the SEIR model was r = 0.70, p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.