Displaying all 5 publications

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  1. Muthupalaniappen L, Aziz SA, Gangaram HB, Hussein SH
    Med J Malaysia, 2009 Sep;64(3):210-2.
    PMID: 20527269 MyJurnal
    Cutaneous vasculitis presents with a variety of clinical morphologies and causes significant morbidity. A total of 85 patients with cutaneous vasculitis at Hospital Kuala Lumpur were retrospectively reviewed. Palpable purpura was seen in 49.4% and frequently involved the lower limbs (50.6%). Identifiable causes include drugs (28.2%), infections (20.0%) and connective tissue disorders (16.5%). Non steroidal antiinflammatory were the commonest group of drugs responsible for 25% of cases while B-haemolytic streptococci was the leading infectious cause (64.7%).
    Matched MeSH terms: Vasculitis/etiology*
  2. Lim LT, Vasudevan V, Shelton J, Vitale AT, Moorthy R
    Retin Cases Brief Rep, 2017 Spring;11(2):119-122.
    PMID: 27305849 DOI: 10.1097/ICB.0000000000000307
    PURPOSE: To report a case series of two cases of granulomatosis with polyangiitis, previously known as Wegener granulomatosis, which developed macular necrosis, not previously associated with granulomatosis with polyangiitis, healed with fibrosis, despite aggressive immune-modulating therapy and good control of systemic disease.

    METHODS: Case series of two cases with observation of treatment progress.

    RESULTS: The results reported the progress of response to treatment in the two cases, which resulted in the final outcome of fibrosis in the macula region, despite being on aggressive immune-modulating therapy and good systemic control.

    CONCLUSION: Granulomatosis with polyangiitis can be associated with macular necrosis leading to fibrosis, unresponsive to immune-modulating therapy.
    Matched MeSH terms: Retinal Vasculitis/etiology*
  3. Barkeh HJ, Muhaya M
    Med J Malaysia, 2002 Dec;57(4):490-2.
    PMID: 12733176
    Systemic lupus erythematosus (SLE) is a common multisystem disorder. However, retinal vasculitis as a primary manifestation of SLE is uncommon, accounting for only 4% of causes of retinal vasculitis. The postulated mechanism appeared to be vaso-occlusion of the retinal arterioles by thrombosis, with resultant ischaemia. Optic neuropathy in SLE is also rare, with a prevalence of 1%. This is a case report of a young lady who presented to us with retinal vasculitis as her initial presentation of SLE. Interestingly, the pathologic mechanism appeared to be inflammatory and not vaso-occlusive.
    Matched MeSH terms: Retinal Vasculitis/etiology*
  4. Latha S, Choon SE, Tey KE, Chee YN
    Med J Malaysia, 2017 12;72(6):345-349.
    PMID: 29308771 MyJurnal
    BACKGROUND: Cutaneous vasculitis is common, yet the risk factors for its chronicity have not been established.

    OBJECTIVE: To describe the clinical spectrum and identify risk factors for chronicity of cutaneous vasculitis.

    METHODS: Retrospective data analysis of 275 patients diagnosed with cutaneous vasculitis from January 2008 to December 2013.

    RESULTS: The mean age was 33.7 (±17.89) years, with female predominance. The majority of patients were Malays (67.3%). Skin biopsy was performed in 110 (40%) patients. The commonest sign was palpable purpura (30.6%). The aetiology remained elusive in 51.3% of patients. Common identifiable causes include infection (19.7%) and connective tissue disease (10.2%). Extracutaneous features were noted in 46.5% of patients. Erythrocyte sedimentation rate and antinuclear antibody were raised in 124 of 170 and 27 of 175 patients with documented results respectively. Cutaneous vasculitis was the presenting symptom in seven patients with newly diagnosed systemic lupus erythematosus. Anti Streptolysin O Titre was positive in 82 of 156 patients with documented results. Despite antibiotics, 31.7% of them had chronic lesions. Prednisolone alone was used in 20% of patients while 16.4% needed steroid-sparing agents. Most patients who needed systemic therapy (62%) had unidentifiable aetiology. Among the 155 patients who remained under follow up, 36.4% had chronic disease, one patient succumbed due to septicaemia, and the rest fully recovered within three months. The presence of ulcerative lesion was significantly associated with developing chronic vasculitis (p=0.003).

    CONCLUSION: The clinical spectrum of cutaneous vasculitis in our population was similar to other studies. Ulcerative lesion predicts a chronic outcome.

    Matched MeSH terms: Vasculitis/etiology
  5. Chew FL, Tajunisah I
    Ocul Immunol Inflamm, 2009 Nov-Dec;17(6):394-5.
    PMID: 20001258 DOI: 10.3109/09273940903260204
    To describe a case of retinal phlebitis associated with autoimmune hemolytic anemia.
    Matched MeSH terms: Retinal Vasculitis/etiology*
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