MyMedR

Fulltext Nasal cylindrical cell papilloma

Subha ST, Prepageran N

Med J Malaysia, 2005 Mar;60(1):103-5.

Inverted papilloma is the most common benign tumor of nose and paranasal sinuses arising from lateral nasal wall and middle meatus. Histologically these tumors are composed of epithelial nests that are inverted, exophytic and cylindrical. Here we describe a clinical case of nasal cylindrical cell papilloma, which was treated by endoscopic excision.

Matched MeSH terms: Nose Neoplasms/diagnosis*; Nose Neoplasms/surgery*

Fulltext Subcutaneous metastasis of olfactory neuroblastoma - an uncommon presentation

Chew YK, Cheong JP, Brito-Mutunayagam S, Khir A, Prepageran N, Mun KS

Med J Malaysia, 2011 Mar;66(1):62-3.

PMID: 23765147

Olfactory neuroblastoma is a rare, slow growing, malignant tumour of neuroectodermal origin that begins in neuroepithelial cells of the olfactory membrane. A metastatic rate of 20% to 60% is reported with the most common site being the cervical lymph node. Other sites include the parotid glands, skin, lungs, bone, liver, orbit, spinal cord and spinal canal. We describe a case of olfactory neuroblastoma presented to us with scalp metastasis.

Matched MeSH terms: Nose Neoplasms*

Fulltext Benign teratoma of the nasal cavity

Sreetharan SS, Prepageran N

Med J Malaysia, 2004 Dec;59(5):678-9.

PMID: 15889573

A teratoma is a true neoplasm composed of an assortment of tissue often alien to the site from it arises. Teratomas of the head and neck are exceedingly rare and usually present in the neonatal period. Most of these are found in the cervical region and nasopharynx. Though most tumors are benign, they are often malignant with regards to the location. Here we present a rare case of benign teratoma arising from the nasal septum and presenting for the first time in a young adult. Appropriate literature is reviewed.

Matched MeSH terms: Nose Neoplasms/pathology*; Nose Neoplasms/surgery

Fulltext Surgical removal of inverted papilloma: case report of endoscopic versus open excision

Prepageran N, Gopala K, Subramaniam KN

Med J Malaysia, 2002 Dec;57(4):493-5.

PMID: 12733177

We describe two cases of nasal inverted papilloma who had different management modalities. Although both were essentially of the same pathology, one underwent endoscopic excision while the other was treated with the more popular lateral rhinotomy and medial maxillectomy. We wish to highlight the different modalities of treatment available for inverted papilloma and a review of published results.

Matched MeSH terms: Nose Neoplasms/diagnosis; Nose Neoplasms/surgery*

Fulltext Malignant lymphoma of nasal septum--a case report

Amin JM, Merican S, Nazarina AR

Med J Malaysia, 1992 Jun;47(2):147-9.

PMID: 1494335

Malignant lymphoma of nasal septum is uncommon. It presents a problem in diagnosis to both otorhinolaryngologist and pathologist. This case report is about one such patient in whom the local disease has been controlled with the treatment of radiotherapy alone. However it is suggested that combined treatment of radiotherapy and cytotoxic therapy might improve the survival rate.

Matched MeSH terms: Nose Neoplasms/diagnosis; Nose Neoplasms/pathology*

A Diagnostic Dilemma of Sinonasal T Cell Lymphoma: Report of A Unique Case and Literature Review

V S, Thamby SP, Al-Hatamleh MAI, Mohamud R, Abdullah B

Gulf J Oncolog, 2019 Sep;1(31):83-89.

PMID: 31591996

BACKGROUND: Natural Killer/T-cell non-Hodgkin lymphomas are rare and aggressive disease of non-Hodgkin lymphoma characterized by angioinvasion, angiodestruction and necrosis. It has a strong association with Epstein-Barr virus (EBV) as the lymphoma cells are almost invariably infected with the clonal episomal form of EBV. Because of their rarity, it is a challenge to diagnose and treat them even to the experienced pathologists.

CASE PRESENTATION: The featured case describes a 40-year-old male who presented with symptoms suggestive for sinusitis. Further diagnostic investigation by the functional endoscopic sinus surgery (FESS) revealed a chronic sinusitis with multiple biopsies showing negative for malignancy, viral and bacterial infections and therefore undiagnosed for sinonasal NK/T-cell lymphoma. Subsequently after a month of surgery, he developed multiple lymph nodes in inguinal where biopsy revealed extranodal NK/T-cell non-Hodgkin lymphoma, high grade but in no time for treatment, he finally succumbed to the illness.

CONCLUSION: The case presented here was initially diagnosed as a chronic sinusitis, not as sinonasal NK/Tcell lymphoma which later developed into extranodal NK/T-cell lymphoma. The prognosis showed improvement for nasal lymphomas but remains poor for disseminated and extranasal lymphomas which are more aggressive with lower survival rate. It is clinically important to differentiate diseases for proper staging and monitoring as they require completely different treatment strategies.

Matched MeSH terms: Nose Neoplasms/diagnosis*; Nose Neoplasms/pathology

Skull Base Primary Ewing Sarcoma: A Radiological Experience of a Rare Disease in an Atypical Location

Saifuddin MSAH, Ng CY, Abdullah MS

Am J Case Rep, 2021 Jun 05;22:e930384.

PMID: 34089579 DOI: 10.12659/AJCR.930384

BACKGROUND Ewing sarcoma and primitive neuroectodermal tumor are rare tumors grouped under the spectrum of the Ewing sarcoma family of tumors. These highly malignant tumors involve the bones and commonly occur in children. Ewing sarcoma of the skull bone accounts for only 1% of all Ewing sarcomas, with primary skull base Ewing sarcoma occurring in less than 1% of cases. We present a case of skull base Ewing sarcoma with complete symptom recovery and near-total radiological resolution. CASE REPORT A 4-year-old girl initially presented with a 2-month history of vomiting, poor oral intake, weight loss, and gradual visual deterioration followed by acute symptoms of fever, breathing difficulties, and seizure. Initial computed tomography and magnetic resonance imaging of the brain displayed a large sinonasal mass with extensive regional infiltration and bony destruction and no evidence of distant metastasis. A transnasal biopsy was taken. The histopathology result revealed features of skull base Ewing sarcoma. The child was given a combination of radiotherapy and chemotherapy, to which she responded well, with a minimal residual tumor. CONCLUSIONS Skull base Ewing sarcoma is a rare entity, presenting a challenge to the reporting radiologists. Differential diagnoses of esthesioneuroblastoma, olfactory neuroepithelioma, and, more commonly, sinonasal carcinoma can be misleading since they have similar radiological appearances to skull base Ewing sarcoma, which differs in treatment regimen and prognosis. Therefore, a combination of histopathological appearance, radiographic findings, and clinical correlation is important to determine the correct diagnosis, establish the appropriate treatment regime, and improve the patient's survival.

Matched MeSH terms: Nose Neoplasms*

A teratoma at the root of the nose

MARSDEN AT

Med J Malaya, 1959 Dec;14:106-10.

PMID: 14421490

Matched MeSH terms: Nose Neoplasms*

Nasal vestibule schwannoma: report of a rare case

Fadzilah I, Salina H, Khairuzzana B, Rahmat O, Primuharsa Putra SH

Ear Nose Throat J, 2014 Jun;93(6):E33-5.

PMID: 24932827

Schwannomas of the nasal cavity and paranasal sinuses are quite rare, especially in the nasal vestibule. We report the case of a 61-year-old woman who presented with a 2-month history of progressively worsening right-sided epistaxis and nasal blockage. Rigid nasoendoscopy showed a mobile, smooth, globular mass occupying the right nasal vestibule. The mass arose from the lateral nasal wall and impinged on the anterior part of the middle turbinate posteriorly. Computed tomography of the paranasal sinuses showed a 3.8 × 1.7-cm enhancing mass in the right nostril. The mass obliterated the nasal cavity and caused mild deviation of the septum. The preoperative histopathologic examination showed positivity for vimentin and S-100 protein, suggesting a diagnosis of schwannoma. The patient underwent an intranasal laser-assisted excision biopsy. The histopathologic examination confirmed the diagnosis of schwannoma. Postoperative recovery was uneventful, and no recurrence was seen in the follow-up period.

Matched MeSH terms: Nose Neoplasms/complications; Nose Neoplasms/diagnosis*; Nose Neoplasms/surgery

Fulltext Endoscopic resection of primary nasoseptal chondrosarcoma

Jenny L, Harvinder S, Gurdeep S

Med J Malaysia, 2008 Oct;63(4):335-6.

PMID: 19385498 MyJurnal

Chondrosarcoma of the nasal septum is an extremely rare malignant tumor. It accounts for only 10% to 20% of primary bone tumors, with approximately 10% found in the head and neck. A case is presented here to illustrate its presentation, evaluation and surgical treatment.

Matched MeSH terms: Nose Neoplasms/pathology; Nose Neoplasms/radiography; Nose Neoplasms/surgery*

Isolated extramedullary plasmacytoma of the middle turbinate

Shahrizal TA, Prepageran N, Rahmat O, Mun KS, Looi LM

Ear Nose Throat J, 2009 Feb;88(2):786-9.

PMID: 19224479

Extramedullary plasmacytoma is a rare plasma cell proliferative disorder with a predilection for the head and neck region. Occasionally, it presents as a solitary lesion in the nasal cavity. We report a case of an isolated lesion in the middle turbinate of the right nasal cavity. The lesion was completely excised via an endoscopic approach. We also review the pathology and management of plasmacytomas in general.

Matched MeSH terms: Nose Neoplasms/diagnosis*; Nose Neoplasms/pathology; Nose Neoplasms/surgery

Fulltext Challenges in the treatment of sinonasal undifferentiated carcinoma: a ray of hope

Norleza AN, Gendeh BS

Med J Malaysia, 2005 Aug;60(3):281-5.

PMID: 16379180 MyJurnal

We studied nine cases of SNUCs presented to the Department of Otorhinolaryngology, Hospital University Kebangsaan Malaysia from 1999 to 2003. There were 8 males and 1 female with ages ranging from 24 to 78 years (mean 46.5y). The racial distribution consisted of 5 Chinese (55.5%), 3 Malays (33.3%) and 1 Indian (11.1%). Three patients were Kadish B (33.3%) and six were Kadish C (66.6%) by classification. In our series 2 years survival was 26.3% and median survival time was 14.2 months.

Matched MeSH terms: Nose Neoplasms/mortality; Nose Neoplasms/pathology; Nose Neoplasms/surgery*

Undifferentiated carcinoma of the sinuses and cranial basis successfully treated with radiochemotherapy. A case report

Chandrasekaran S, Baba AA, Othman N, Jayakumar CR

Chemotherapy, 1994 Sep-Oct;40(5):357-61.

PMID: 7956460

The frustration and disappointment in managing advanced cancers of the nose and paranasal sinuses are well known. We report a case of a successful treatment of such a tumour in a 37-year-old soldier, using a combination of therapy including surgery, chemotherapy and radiation. Each mode of treatment is discussed.

Matched MeSH terms: Nose Neoplasms/drug therapy; Nose Neoplasms/radiotherapy; Nose Neoplasms/surgery; Nose Neoplasms/therapy*

Fulltext Infrasellar craniopharyngioma of the posterior nasal septum: a rare entity

Chiun KC, Tang IP, Tharumalingam V, Nurshaline Pauline HK

Med J Malaysia, 2012 Feb;67(1):131-2.

PMID: 22582569 MyJurnal

To report an unusual location of infrasellar craniopharyngioma in a peadiatric patient.

Matched MeSH terms: Nose Neoplasms/diagnosis*

Fulltext The use of paramedian forehead flap reconstruction after wide excision of basal cell carcinoma of the nose

Chew YK, Noorizan Y, Khir A, Brito-Mutunayagam S, Prepagaran N

Med J Malaysia, 2008 Oct;63(4):339-40.

PMID: 19385500 MyJurnal

Basal cell carcinoma (BCC) is an indolent, slow-growing malignant skin tumour. Approximately 70% of the tumours occur in the head and neck region. The nose is a common site for malignant skin tumours, such as basal cell carcinoma and squamous cell carcinoma because it is exposed to the sun. Excision of the BCC will leave the nose with a soft tissue defect which requires reconstruction. This report illustrates a case of BCC of nose whereby a wide excision and reconstruction was performed with a paramedian forehead flap.

Matched MeSH terms: Nose Neoplasms/surgery*

Fulltext Sinonasal malignant melanocytic melanoma: a rare case report

Pathma L, Philip R, Harvinder S, Manjit S

Med J Malaysia, 2008 Jun;63(2):152-3.

PMID: 18942306 MyJurnal

Malignant melanocytic melanoma is a rare sinonasal malignancy. We present a case report of an elderly lady who presented with epistaxis and intranasal polyps. Computed tomography revealed soft tissue mass in the oropharynx, nasopharynx, left ethmoid and entire maxillary sinus. The mass was removed via endoscopic medial maxillectomy. Histopathology examination revealed sinonasal melanocytic malignant melanoma. At present 17 months postoperatively she is symptom free with no recurrence and under regular follow up.

Matched MeSH terms: Nose Neoplasms/pathology*

Teratocarcinosarcoma of the nasal cavity and ethmoid

Sharma HS, Abdullah JM, Othman NH, Muhamad M

J Laryngol Otol, 1998 Jul;112(7):682-6.

PMID: 9775307

Sinonasal teratocarcinosarcoma is very unusual malignant neoplasm histologically consisting of an epithelial element and one or more mesenchymal components. This is a report of teratocarcinosarcoma, in a 74-year-old male, involving the right nasal cavity and ethmoids with intracranial extension. The tumour was totally resected via the craniofacial approach and the patient was given post-operative chemotherapy. Extensive tumour necrosis, rapid growth and local destruction are the prominent features of this tumour. The clinical presentation, pathological features and clinical course of this rare malignancy are discussed with a review of the literature.

Matched MeSH terms: Nose Neoplasms/pathology*

Unusual presentation of chorion epithelioma malignum

Subramanyam C, Lal M

Med J Malaya, 1970 Jun;24(4):306-7.

PMID: 4248354

Matched MeSH terms: Nose Neoplasms/pathology*

Primary sinonasal Ewing sarcoma: A case report

Amri MF, Abdullah A, Azmi MI, Mohd Zaki F, Md Pauzi SH

Malays J Pathol, 2021 Aug;43(2):319-325.

PMID: 34448796

BACKGROUND: Ewing sarcoma (ES) is an aggressive tumour which is typically skeletal in origin. ES involving the head and neck region is uncommon and can be easily confused with other small round blue cell tumours. We herein present a rare case of ES involving the sinonasal area.

CASE PRESENTATION: A 5-year-old Somalian boy with no known medical illness presented with progressive nasal blockage associated with clear nasal discharge and intermittent spontaneous epistaxis for three months. CT paranasal sinus and neck region revealed poorly enhancing expansile mass in the right maxillary sinus with areas of necrosis within. Initial radiological differential diagnoses were lymphoma and rhabdomyosarcoma. The mass was biopsied and histologically showed diffuse sheets of small round blue cells that was positive to CD99, NSE and vimentin. The muscle and lymphoid markers were negative. Fluorescence in-situ hybridisation (FISH) study revealed the presence of EWSR1 gene rearrangement thus diagnosis of ES was rendered.

CONCLUSIONS: ES of sinonasal tract is a rare entity and its pathological features significantly overlap with others small round blue cells tumour. Demonstration of EWSR1 gene translocation is recommended for the diagnosis of ES particularly at uncommon sites.

Matched MeSH terms: Nose Neoplasms*

Fulltext Nasal and nasal-type natural killer (NK)/T-cell lymphoma: immunophenotype and Epstein-Barr virus (EBV) association

Peh SC, Danielle Quen QW

Med J Malaysia, 2003 Jun;58(2):196-204.

PMID: 14569739

Epstein-Barr virus (EBV) is believed to have a pathogenic role in lymphomas of the upper-aerodigestive tract. This study aims to elucidate the virus association pattern in nasal and nasal-type NK/T-cell lymphomas, and in sequential biopsies of these tumours. A total of 31 cases of previously diagnosed as lethal midline granuloma. Stewart's granuloma, nasal T-cell non-Hodgkin's lymphoma (T-NHL) and NK/T-cell lymphomas from all anatomical sites were retrieved from the files for the study. Reviews of these cases confirm 8 nasal T-NHL, 19 nasal and 4 extranasal lymphomas of NK/T-cell phenotype from 10 Malays, 18 Chinese, 2 Indian and 1 Kadazan. The male: female ratio was 2.4: 1. All T- and NK/T-cell lymphomas strongly expressed TIA-1 and 63% expressed CD2. The majority of NK/T-cell lymphoma occurred in Chinese (13/23), of which 12/13 (92%) of these cases were associated with EBV. Of the 15 nasal and 9 tonsillar B-cell lymphomas included for a comparison study, only 3 (20%) of the nasal cases were associated with EBV (1 male Chinese, 1 female Chinese and 1 male of other ethnic group). Eight cases of NK/T-cell tumours with sequential biopsies show persistence of EBV, irrespective of the interval and sites of subsequent presentations. This study confirms the cytotoxic nature of NK/T-cell tumour and that EBV is strongly associated with the disease regardless of the anatomical site of presentation and ethnicity. However, nasal and paranasal lymphomas of all phenotypes appear to show higher predilection of EBV association in the ethnic Chinese when compared to non-Chinese.

Matched MeSH terms: Nose Neoplasms/genetics; Nose Neoplasms/immunology*; Nose Neoplasms/virology*

Displaying publications 1 - 20 of 39 in total