MyMedR

An Obstructed Malignant Inflammatory Myofibroblastic Tumour of the Rectum

Zainal Abidin ZA, Azizan N, Hayati F, Mra A, Mohd Azman ZA

Kathmandu Univ Med J (KUMJ), 2018 7 1;16(63):272-274.

PMID: 31719321

Inflammatory myofibroblastic tumour is rare but more common in children. It shows an immunophenotypic features of myofibroblastic differentiation, hence bearing neoplastic potential. The diagnosis is challenging especially if it involves rectum. Surgical resection is the mainstay of treatment if clinically obstructed. A 65-year-old gentleman presented with intestinal obstruction, which then followed by a hartmann's procedure. Final diagnosis is a rare case of inflammatory myofibroblastic tumour of the rectum. We discuss its genetic involvement with a literature review.

Matched MeSH terms: Neoplasms, Muscle Tissue/diagnosis*; Neoplasms, Muscle Tissue/microbiology; Neoplasms, Muscle Tissue/pathology; Neoplasms, Muscle Tissue/surgery

Congenital epulis--a case report

Ramanathan K, Karpal Singh

Med J Malaysia, 1973 Sep;28(1):55-7.

PMID: 4361092

Matched MeSH terms: Neoplasms, Muscle Tissue/pathology*

Alveolar soft part sarcoma: a case report

Sengupta S, Murugasu R

Med J Malaya, 1970 Sep;25(1):70-2.

PMID: 4249502

Matched MeSH terms: Neoplasms, Muscle Tissue/pathology*

Metachronous inflammatory myofibroblastic tumour in the temporal bone: case report

Goh BS, Tan SP, Husain S, Rose IM, Saim L

J Laryngol Otol, 2009 Oct;123(10):1184-7.

PMID: 19192318 DOI: 10.1017/S0022215109004642

We report an extremely rare case of metachronous inflammatory myofibroblastic tumour in the temporal bone.

Matched MeSH terms: Neoplasms, Muscle Tissue/pathology; Neoplasms, Muscle Tissue/surgery*

Myofibroblastoma of the breast

Shanmugasiva VV, Ramli Hamid MT, Fadzli F, Shaleen Kaur KS, Abd Rahman N, Rahmat K

Malays J Pathol, 2018 Dec;40(3):349-353.

PMID: 30580368

INTRODUCTION: Myofibroblastoma is a rare benign mesenchymal tumour arising from the stromal elements of the breast tissue. Histopathological variants such as classic, cellular, collagenous / fibrous, lipomatous, infiltrative, myxoid and epithelioid have been identified. Most myofibroblastomas are immunoreactive for CD34, actin, CD10 and desmin, usually express oestrogen receptor (ER), progesterone receptor (PR) and variably express androgen receptor (AR).

CASE REPORT: We report a case of myofibroblastoma in an octogenarian male presenting with painless solitary breast lump. Mammography (digital tomosynthesis) and ultrasound showed a well-circumscribed hyperdense mass and hypoechoic, solid, oval mass with peripheral vascularity respectively. Patient underwent wide local excision.

DISCUSSION: Diverse characteristics of myofibroblastoma on imaging necessitates histopathological analysis for an accurate diagnosis. Myofibroblastoma are often confused with fibroadenomas due to the benign imaging characteristics and with malignant neoplasia due to their wide morphological spectrum. Surgical excision is considered curative.

Matched MeSH terms: Neoplasms, Muscle Tissue/pathology*; Neoplasms, Muscle Tissue/surgery

Fulltext Periadrenal inflammatory myofibroblastic tumour: half a decade before cure

Abdul Ghani R, Mohamed Shah FZ, Hanafiah M, Abdul Aziz M

BMJ Case Rep, 2019 Feb 01;12(2).

PMID: 30709882 DOI: 10.1136/bcr-2018-225687

A 30-year-old ex-smoker with a background history of childhood asthma presented with worsening shortness of breath despite receiving high doses of oral corticosteroid for pemphigus vulgaris which was diagnosed 5 years earlier. A high-resolution CT examination of the thorax reported non-specific bronchiectatic changes and revealed an incidental suprarenal mass. A subsequent CT scan confirmed a large adrenal mass with areas of necrosis and calcification. Serum renin and aldosterone, urinary catecholamine and 5-hydroxyindoleacetic acid were within normal limits. Surgical intervention was delayed due to difficulty in optimising preoperative respiratory functions. He finally underwent a midline laparotomy for removal of the tumour. Histopathological examinations revealed extrapulmonary inflammatory myofibroblastic tumour arising from the periadrenal soft-tissue, with presence of normal adrenal gland. He showed immediate improvements of his asthmatic symptoms and pemphigus vulgaris following the surgery. His oral steroid was rapidly reduced and he achieved complete remission 2 months later.

Matched MeSH terms: Neoplasms, Muscle Tissue/complications; Neoplasms, Muscle Tissue/diagnosis*

Fulltext Granular cells in a benign parotid gland tumour: an attempt to understand its probable histogenesis

George, T., Zain, R.B., Abraham, M.T.

Ann Dent, 2011;18(1):30-35.

MyJurnal

Tumours that occur in the oral cavity may contain granular cells as a component of their pathology. A more common granular cell lesion occurring in the head and neck region is the granular cell tumour (GCT) that usually arises in the tongue or the buccal mucosa. Granular cell tumours are very rare in the parotid gland with only 11 cases previously reported in the English literature. We report a case of a benign tumour involving the parotid gland of a young female patient. The case was diagnostically challenging due to the large proportion of granular cells masking the underlying pathology. Histopathological features and immunohistochemical analysis favoured a diagnosis of a benign GCT. The present report provides an insight into the differential diagnosis and attempts to characterise the granular cells with the use of the wellestablished immunohistochemical markers and conventional histopathological techniques.

Matched MeSH terms: Neoplasms, Muscle Tissue

Osteosarcoma presenting as an aggressive nodular mass in the region of the mandible

Ong ST, Shim CK, Ng KH, Siar CH

J Oral Sci, 2004 Mar;46(1):55-9.

PMID: 15141725

Osteosarcomas are highly malignant neoplasms of bone that are challenging to diagnose. These neoplasms often show atypical behavior. In the initial phase they may present as nondescript bony swellings with an indolent growth rate, only to become overtly aggressive and malignant towards the later phase of the disease. Similarly, the histological growth pattern of this neoplasm can be quite diverse, presenting with areas that mimic benign myofibroblastic tumors, giant cell granulomatous conditions and partial encapsulation. The final diagnosis of an osteosarcoma is often reached after thorough sampling and examination of multiple biopsy specimens. All these clinical features and histological diagnostic difficulties were encountered in a case of osteosarcoma affecting the right mandible of a 62-year-old Chinese woman described here. The diagnostic lessons accrued from this case are discussed.

Matched MeSH terms: Neoplasms, Muscle Tissue/diagnosis

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