MyMedR

Fulltext The use of immunohistochemistry in an oral pathology laboratory

Ajura AJ, Sumairi I, Lau SH

Malays J Pathol, 2007 Dec;29(2):101-5.

PMID: 19108402 MyJurnal

Immunohistochemistry has become part of normal routine diagnostic work in the Stomatology Unit, Institute for Medical Research, Kuala Lumpur. Of 9523 cases received from the year 2000 to 2005, 197 cases (2.1%) required immunohistochemical staining. These cases ranged from benign to malignant lesions. They include lymphomas (n=41), epithelial tumours (n=29), neural lesions (n=21), fibroblastic/myofibroblastic tumours (n=16), small round cell tumour (n=11), vascular tumours (n=4), smooth muscle tumours (n=4), myxomatous tumours (n=4) and skeletal muscle tumours (n=1). In most of the cases (69.5%), immunohistochemical staining was mandatory to reach a definite diagnosis, while 60 cases (30.5%) required immunohistochemistry in confirming the diagnosis. In 32 cases (16.2%), definitive diagnosis could not be made due to the small size of the specimens received or the results of immunohistochemistry were inconclusive. Standardization of techniques, competent medical laboratory technologists and sufficient budget allocation are important in producing a high quality immunohistochemistry service.

Matched MeSH terms: Mouth Diseases/diagnosis*

Audit of Turnaround Time for a Training Oral Histopathology Laboratory in Malaysia

Chan SW, Liew LH, Wong GR, Kallarakkal TG, Abraham MT, Ramanathan A, et al.

Int. J. Surg. Pathol., 2016 Aug;24(5):401-9.

PMID: 27006298 DOI: 10.1177/1066896916639372

BACKGROUND: Turnaround time (TAT) is the benchmark to assess the performance of a laboratory, pathologists, and pathology services, but there are few articles on TAT of surgical pathology, particularly in relation to oral or head and neck specimens. This study investigates the TAT for oral histopathology reporting in an academic institution's training laboratory and offers recommendations to achieve better overall quality of diagnostic services.

METHODS: This study examined data obtained from biopsy request forms for specimens received from the Oro-Maxillofacial Surgery Department of Hospital Tengku Ampuan Rahimah Klang in the Oral Pathology Diagnostic Laboratory of the Faculty of Dentistry, University of Malaya, over a period of 3 years between January 2012 and October 2014.

RESULTS: TAT for surgical and decalcified specimens were increased significantly compared to biopsies. Additional special handling did not influence TAT, but increased specimen volume resulted in greater TAT. Slide interpretation was the most time-consuming stage during histopathology reporting. Overall, mean TAT was acceptable for most specimens, but the TAT goals were less than satisfactory.

CONCLUSION: A TAT goal appropriate for this laboratory may hence be established based on this study. Collective efforts to improve the TAT for various specimens are essential for better laboratory performance in the future.

Matched MeSH terms: Mouth Diseases/diagnosis

Mouth pain and cheek numbness

Chong W, Musa MSH, Sugumaran V

Emerg Med J, 2020 Jul;37(7):436-443.

PMID: 32616656 DOI: 10.1136/emermed-2019-209395

Matched MeSH terms: Mouth Diseases/diagnosis*

Primary mucocutaneous histoplasmosis

Dutt AK, Garai BK

Med J Malaya, 1970 Mar;24(3):231-3.

PMID: 4246808

Matched MeSH terms: Mouth Diseases/diagnosis*

Oral histoplasmosis presenting as oral ulcer in a non-HIV patient

Rahman MT, Bakar NH, Philip R, Shamsudin AR

Southeast Asian J. Trop. Med. Public Health, 2004 Jun;35(2):388-90.

PMID: 15691142

A 40-year-old man presented with chronic mouth ulcer for the last six months. Histopathological examination of the biopsy from the lesion confirmed a diagnosis of histoplasmosis. Although histoplasmosis commonly manifests in immunocompromized patients, like HIV, the present case was negative for HIV. Histoplasmosis is endemic in certain parts of the world and it is comparatively rare in the South Asian region, particularly Malaysia. Thirty-seven cases of histoplasmosis were reported from Malaysia (Ng and Siar, 1996), between July 1967 and October 1997. Despite the apparent rarity of the disease, clinicians and pathologists should be aware of the possibility of histoplasmosis when cases of oral ulcer are encountered.

Matched MeSH terms: Mouth Diseases/diagnosis*

Heterotopic neuroglial tissue presenting as oral cavity mass with intracranial extension

Marina MB, Zurin AR, Muhaizan WM, Primuharsa Putra SH, Azizi AB, Kenali MS

Int J Pediatr Otorhinolaryngol, 2005 Nov;69(11):1587-90.

PMID: 15935483

Heterotopic neuroglial tissue is a rare congenital lesion with predilection in head and neck region. We report a case of a newborn who presented with an oral cavity mass with intracranial extension and later respiratory distress that was successfully excised via transcranial and transcervical approach.

Matched MeSH terms: Mouth Diseases/diagnosis*

Pemphigus vulgaris

Nayak V, Kini R, Rao PK, Shetty U

BMJ Case Rep, 2020 May 13;13(5).

PMID: 32404374 DOI: 10.1136/bcr-2020-235410

Matched MeSH terms: Mouth Diseases/diagnosis*

Biopsy techniques in the diagnosis and treatment of mouth diseases and tumours

Ramanathan K

Med J Malaysia, 1979 Sep;34(1):28-31.

PMID: 542146

Matched MeSH terms: Mouth Diseases/diagnosis*

Painful oral and genital ulcers

Ch'ng CC, Wong SM, Lee YY

Cutis, 2017 Jan;99(1):E1-E3.

PMID: 28207013

Matched MeSH terms: Mouth Diseases/diagnosis*

Fulltext Massive airway myiasis: an extreme rarity

Teah MK, Chu YM, Shanmuganathan SD, Yeap TB

BMJ Case Rep, 2020 Dec 09;13(12).

PMID: 33298493 DOI: 10.1136/bcr-2020-237764

Intubations are important live saving skills to maintain adequate ventilation and oxygenation. Common indications include impending upper airway obstruction, respiratory failure and impaired conscious level. Oral myiasis is an infrequently found disease which is characterised by ectoparasitic infestation of body tissues by fly maggots.We present a case report and share valuable experiences on a patient with massive airway myiasis causing upper airway obstruction which require emergency intubation.

Matched MeSH terms: Mouth Diseases/diagnosis*

Fulltext Oral hyperpigmented lesions--a case study

Kwa SK, Gupta ED

Aust Fam Physician, 2013 Jul;42(7):490-1.

PMID: 23826603

An overweight woman, aged 58 years, presented for follow up of hypertension, diabetes and dyslipidaemia. She was noted to have hyperpigmented brown macules on the inner surface of the lower lip and buccal mucosa (Figure 1). She stated that she had first noticed these lesions when aged in her 40s. Her mother died at age 58 years from gastric cancer with extensive metastases, and her brother died at age 45 years from colon cancer with spread to the liver and lungs.

Matched MeSH terms: Mouth Diseases/diagnosis*

Exophytic oral verrucous hyperplasia: a new entity

Patil S, Warnakulasuriya S, Raj T, Sanketh DS, Rao RS

J Investig Clin Dent, 2016 Nov;7(4):417-423.

PMID: 26075572 DOI: 10.1111/jicd.12166

OBJECTIVE: Exophytic oral verrucous hyperplasia (OVH) is a new entity described by an expert working group from South Asia. First reported in Taiwan, there are no reports so far from an Indian population. The aim was to use the microscopic features described by the expert group to differentiate OVH from other oral verruco-papillary lesions in an Indian archive.

MATERIALS AND METHODS: In a retrospective multicentre study, using pathology archives, 188 verruco-papillary lesions were retrieved from pathology archives. A proforma listing histopathological criteria for OVH based on published guidelines (Annals of Dentistry, University of Malaya, 2013) was used. Patients' demographic and clinical data were transcribed from patient charts. The Pearson chi-square test was used to determine associations between clinical and histopathological features.

RESULTS: Of 188 oral verruco-papillary lesions that were evaluated, based on microscopic features the cases were reclassified as OVH (57), verrucous carcinoma (VC) (84), oral squamous cell carcinoma (16), and other verruco-papillary lesions (31). Both OVH (70%) and VC (60%) showed male predominance and commonly affected buccal mucosa (OVH 74% and VC 57%). Absence of downward growth of the hyperplastic epithelium into lamina propria when compared with the level of the basement membrane of the adjacent normal epithelium was a distinct feature in OVH. Keratin plugging, epithelial dysplasia and subepithelial lymphocytic infiltration were found to be significantly different (P

Matched MeSH terms: Mouth Diseases/diagnosis

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