MyMedR

Fulltext Venous Air Embolism during Elective Craniotomy for Parasagittal Meningioma

Hassan WMNW, Asmah Z, Saedah A

Med J Malaysia, 2013;68(1):69-70.

We report a case of a 59 year old man who developed venous air embolism (VAE) during an elective craniotomy for parasagittal meningioma resection. The surgery was done in the supine position with slightly elevated head position. VAE was provisionally diagnosed by sudden decreased in the end tidal carbon dioxide pressure from 34 to 18 mmHg, followed by marked hypotension and atrial fibrillation. Prompt central venous blood aspiration, aggressive resuscitation and inotropic support managed to stabilize the patient. Post operatively, he was admitted in neuro intensive care unit and made a good recovery without serious complications.

Matched MeSH terms: Meningioma*

Fulltext Primary non-Hodgkin's lymphoma of the cranial vault mimicking a meningioma: a case report

Muin IA, Saffari HM, Hasimah YN

Med J Malaysia, 1997 Mar;52(1):86-8.

PMID: 10968060

Primary non-Hodgkin's lymphoma of the brain is rare. Majority of the lesions are intraaxial, multicentric and involve the leptomeninges. We report a case of malignant primary non-Hodgkin's lymphoma arising from the cranial vault. Computed tomography of the brain showed an extraaxial lesion in the right parietal region mimicking a meningioma.

Matched MeSH terms: Meningioma/diagnosis*

Fulltext Intracranial meningiomas: a report of 13 cases

Djavadkhani K, Rahmat H

Med J Malaysia, 1985 Dec;40(4):321-4.

PMID: 3842733

This is a report of 13 cases of meningiomas treated in the Neurosurgical Unit, Universiti Kebangsaan Malaysia, General Hospital, Kuala Lumpur, over a period of nine months from September 1982.

Matched MeSH terms: Meningioma*

Xanthomatous meningioma: A metaplastic or degenerative phenomenon?

Wong YP, Tan GC, Kumar R

Neuropathology, 2018 Dec;38(6):619-623.

PMID: 30187570 DOI: 10.1111/neup.12511

Xanthomatous changes can be observed in various conditions including primary xanthomatosis that is linked to an underlying hypercholesterolemia and more commonly associated with secondary xanthomatous degenerative processes in neoplasm and chronic inflammation. Meningioma with extensive xanthomatous change is exceedingly rare. The presence of cholesterol clefts within this peculiar meningioma subtype has not been described. Herein, we report an unusual case of xanthomatous meningioma in an 83-year-old normolipidemic woman, who presented to us with worsening lower limb weakness and global aphasia. There was increasing evidence to suggest that the presence of xanthomatous changes in long-standing meningioma is merely a sequela of cellular degeneration rather than true metaplastic change as previously hypothesized. Hence, the diagnosis of "xanthomatous meningioma" in the metaplastic category should be revisited and considered as a distinct histological subtype. The possible histogenesis of such intriguing phenomenon is discussed with a review of the literature.

Matched MeSH terms: Meningioma/pathology*

Fulltext Meningioma--the Sarawak General Hospital experience

Wong SH, Chan SH

Med J Malaysia, 2002 Dec;57(4):467-73.

PMID: 12733172

The aim of this study was to determine the factors for the large size of intracranial meningiomas at the time of presentation to the Sarawak General Hospital. The data was collected prospectively from 1/3/2000 to 28/2/2001. During this period a total of 57 cases of intracranial tumours were operated upon. Twenty of these cases (35%) were meningioma, making meningioma the most common intracranial tumour operated in the Neurosurgery service here with one to two cases operated per month. Headache was the most common symptom. The average duration of symptoms before the diagnosis was made was twenty-five months, the longest being fifteen years. The patients needed an average of seven visits prior to the diagnosis.

Matched MeSH terms: Meningioma/diagnosis; Meningioma/epidemiology*; Meningioma/therapy

Large falcine meningioma presented as treatment-resistant depression: A case report

Sim SK, Khairul Aizad A, Lim SS, Wong A

Med J Malaysia, 2019 02;74(1):87-89.

PMID: 30846670

Large intracranial tumour may present only with psychiatric symptoms without any neurological deficits. Delay in surgical treatment may significantly affect the quality of life in these patients. We report a case of a young engineering student who was diagnosed as treatment-resistant depression without initial neuroimaging study. Further neuroimaging studies revealed he has a large falcine meningioma. His psychiatric symptoms resolved following surgical resection of the tumour. We emphasized the importance of initial neuroimaging study in young patients presenting with psychiatric symptoms.

Matched MeSH terms: Meningioma/complications; Meningioma/diagnosis*; Meningioma/psychology

Fulltext Meningioma with intracranial haemorrhage: A rare occurrence.

Ho, C.C.K., Benedict, M.S.

International Medical Journal Malaysia, 2008;7(1):0-0.

MyJurnal

Meningiomas with intracranial haemorrhage is a rare occurrence and carries a high mortality rate. We present here a case we encountered, where intratumoural, subdural and intraventricular haemorrhage occurred. The pathophysiology and mechanism of intracranial tumoural haemorrhage, is discussed.

Matched MeSH terms: Meningioma

A parapharyngeal meningioma presenting as a neck mass and multiple cranial nerve palsies

Mohamad I, Abdullah B, Idris Z, Naik VR, Bhavaraju VM

Ceylon Med J, 2011 Jun;56(2):73-4.

PMID: 21789871

Matched MeSH terms: Meningioma/complications; Meningioma/diagnosis*; Meningioma/pathology; Meningioma/surgery

A rare case of paediatric meningioma masquerading as intra-axial lesion

Tan LY, Tan AP

Med J Malaysia, 2018 12;73(6):439-440.

PMID: 30647227

Meningiomas are neoplasm arising from meningoepithelial cells, most commonly in the fifth to sixth decade of life. Meningiomas are rare in paediatric population, accounting for 0.4-4.1% of all paediatric tumours and less than 3% of paediatric brain tumours. However, meningiomas represent the most common dural based tumours in children. We describe a rare case of paediatric fibroblastic meningioma within the left middle cranial fossa masquerading as an intra-axial mass lesion. Our discussion will be centred on atypical features of paediatric meningiomas and differential diagnosis of extra-axial mass lesion in the paediatric population.

Matched MeSH terms: Meningioma/diagnosis*

Fulltext Somatic mitochondrial DNA D-loop mutations in meningioma discovered: A preliminary data

Mohamed Yusoff AA, Mohd Khair SZN, Wan Abdullah WS, Abd Radzak SM, Abdullah JM

J Cancer Res Ther, 2020 12 22;16(6):1517-1521.

PMID: 33342822 DOI: 10.4103/jcrt.JCRT_1132_16

Background and Objective: Meningiomas are among the most common intracranial tumors of the central nervous system. It is widely accepted that the initiation and progression of meningiomas involve the accumulation of nucleus genetic alterations, but little is known about the implication of mitochondrial genomic alterations during development of these tumors. The human mitochondrial DNA (mtDNA) contains a short hypervariable, noncoding displacement loop control region known as the D-Loop. Alterations in the mtDNA D-loop have been reported to occur in most types of human cancers. The purpose of this study was to assess the mtDNA D-loop mutations in Malaysian meningioma patients.

Materials and Methods: Genomic DNA was extracted from 21 fresh-frozen tumor tissues and blood samples of the same meningioma patients. The entire mtDNA D-loop region (positions 16024-576) was polymerase chain reaction amplified using designed primers, and then amplification products were purified before the direct DNA sequencing proceeds.

Results: Overall, 10 (47.6%) patients were detected to harbor a total of 27 somatic mtDNA D-loop mutations. Most of these mtDNA mutations were identified in the hypervariable segment II (40.7%), with 33.3% being located mainly in the conserved sequence block II of the D310 sequence. Furthermore, 58 different germline variations were observed at 21 nucleotide positions.

Conclusion: Our results suggest that mtDNA alterations in the D-loop region may be an important and early event in developing meningioma. Further studies are needed, including validation in a larger patient cohort, to verify the clinicopathological outcomes of mtDNA mutation biomarkers in meningiomas.

Matched MeSH terms: Meningioma/blood; Meningioma/genetics*; Meningioma/pathology

Meningioma Mimicking Fibrous Dysplasia

Kamaluddin NA, Samsudin AHZ, Wan Hitam WH, Ibrahim M

Cureus, 2019 Sep 27;11(9):e5782.

PMID: 31723541 DOI: 10.7759/cureus.5782

Despite being among the common primary intracranial tumors, intraosseous craniofacial meningioma is the least common subtype of meningioma accounting for only 1-2% of intracranial meningiomas. Interestingly, it can display clinical and radiologic features that can be confused for fibrous dysplasia. Scan imaging and biopsy are crucial for the diagnosis as well as for further proper treatment. We report a case of unilateral eye proptosis and optic neuropathy which was initially thought for fibrous dysplasia. Later the histopathology revealed meningioma grade 1. As the clinical presentations are almost undifferentiated, diagnosis and further prompt treatment are challenging.

Matched MeSH terms: Meningioma

Fulltext Prevalence of mitochondrial DNA common deletion in patients with gliomas and meningiomas: A first report from a Malaysian study group

Mohamed Yusoff AA, Mohd Khair SZN, Abd Radzak SM, Idris Z, Lee HC

J Chin Med Assoc, 2020 Sep;83(9):838-844.

PMID: 32732530 DOI: 10.1097/JCMA.0000000000000401

BACKGROUND: The 4977-bp common deletion (mtDNA) is a well-established mitochondrial genome alteration that has been described in various types of human cancers. However, to date, no studies on mtDNA in brain tumors have been reported. The present study aimed to determine mtDNA prevalence in common brain tumors, specifically, low- and high-grade gliomas (LGGs and HGGs), and meningiomas in Malaysian cases. Its correlation with clinicopathological parameters was also evaluated.

METHODS: A total of 50 patients with pathologically confirmed brain tumors (13 LGGs, 20 HGGs, and 17 meningiomas) were enrolled in this study. mtDNA was detected by using polymerase chain reaction (PCR) technique and later confirmed via Sanger DNA sequencing.

RESULTS: Overall, mtDNA was observed in 16 (32%) patients and it was significantly correlated with the type of tumor group and sex, being more common in the HGG group and in male patients.

CONCLUSION: The prevalence of mtDNA in Malaysian glioma and meningioma cases has been described for the first time and it was, indeed, comparable with previously published studies. This study provides initial insights into mtDNA in brain tumor and these findings can serve as new data for the global mitochondrial DNA mutations database.

Matched MeSH terms: Meningioma/genetics*; Meningioma/metabolism; Meningioma/pathology

Cystic Meningioma Masquerading as a Metastatic Tumor: A Case Report

Ramanathan N, Kamaruddin KA, Othman A, Mustafa F, Awang MS

Malays J Med Sci, 2016 May;23(3):92-4.

PMID: 27418876 MyJurnal

Cystic meningioma is a rare form of intracranial meningioma. Meningiomas are typically solid tumors but may rarely have cystic components. The diagnosis of cystic meningioma is clinically challenging as the finding of multiple intra-axial tumors, including metastatic tumors, is relatively common. We report a case of cystic meningioma initially diagnosed as a metastatic tumor from a recurrence of acute lymphoid leukemia. However, postoperative histopathological examination demonstrated an atypical meningioma.

Matched MeSH terms: Meningioma

Fulltext Complete paraparesis following resection of parasagittal meningioma: recovering function with an early intensive neurorehabilitation program

Mazlan M, Fauzi AA

Med J Malaysia, 2011 Oct;66(4):371-3.

PMID: 22299564 MyJurnal

Paraparesis can occur as a primary presentation of brain pathology at the motor strip along the parasagittal region. It could also occur as a neurological complication especially following resection of parasagittal meningioma with infiltration of the superior sagittal sinus (SSS). We report a case of a complete paraparesis immediately following resection of bilateral parasagittal meningioma with infiltration of the middle third of the SSS. A gradual improvement in neurological recovery and functional outcome was observed over a period of one year after undergoing an intensive neurorehabilitation program beginning from the acute inpatient phase post surgery.

Matched MeSH terms: Meningioma/physiopathology; Meningioma/surgery*

Hypoglossal nerve tumor: A rare primary extracranial meningioma of the neck

Zulkiflee AB, Prepageran N, Rahmat O, Jayalaskhmi P, Sharizal T

Ear Nose Throat J, 2012 Nov;91(11):E26-9.

PMID: 23288802

We report a case of primary extracranial meningioma arising from the hypoglossal nerve in a 54-year-old man who presented with a 9-month history of hoarseness and progressive dysphagia. He had also noticed that his tongue was deviated to the left and, as a result, he was having difficulty pronouncing words. Examination revealed fasciculation and muscle wasting on the left side of the tongue. Other cranial nerve functions were normal. Contrast-enhanced computed tomography detected a heterogeneous mass that had arisen above the bifurcation of the left common carotid artery and had extended to near the skull base. Transcervical excision of the tumor was performed, and histopathology identified it as a meningioma of the hypoglossal nerve. The patient recovered uneventfully, and he was without recurrence at more than 2 years of follow-up. A primary extracranial meningioma is extremely rare, and its presentation may be subtle. A thorough investigation is necessary to avoid fatal compressive symptoms.

Matched MeSH terms: Meningioma/diagnosis*; Meningioma/surgery

Fulltext Early Malaysian experience on the use of head and neck localizers in the precision radiotherapy of intra and extra cranial sites for first 28 cases

Zamzuri I, Idris NR, Mar W, Abdullah JM, Zakaria A, Biswal BM

Med J Malaysia, 2006 Dec;61(5):621-5.

PMID: 17623965 MyJurnal

Precision Radiotherapy at high doses require a fixed, referable target point. The frame system fulfills the required criteria by making the target point relocatable and fixed within a stereotactic space. Since December 2001, we have treated 28 central and peripheral nervous system lesions using either radiosurgery as a single high dose fraction or fractionated 3-dimensional conformal radiotherapy using a lower dose and a multi-leaf collimator. Various pathological lesions either benign or malignant were treated. Eighty six percent of our treated lesions showed growth restraint, preventing them from causing new symptoms with a median follow-up duration of 20.5 months. However, the true benefit from this technique would require a long-term follow-up to document the progress.

Matched MeSH terms: Meningioma/radiotherapy; Meningioma/surgery

Syringomyelia associated with a cauda equina meningioma involving the conus medullaris

Chee CP, Tan CT, Nuruddin R

Br J Neurosurg, 1990;4(6):529-33.

PMID: 2076215

An unusual case of syringomyelia secondary to a cauda equina meningioma involving the conus medullaris is described. The tumour was totally removed with decompression of an adjacent cyst and syrinx resulting in resolution of the symptoms and radiological appearance.

Matched MeSH terms: Meningioma/complications*; Meningioma/surgery

Fulltext An unexpected lesion in cerebellopontine angle: hemangiopericytoma

Teoh JW, Goh BS, Shahizon Azura MM, Siti Aishah MA, Nor Hafliza MS

Med J Malaysia, 2014 Jun;69(3):146-7.

PMID: 25326360 MyJurnal

hemangiopericytoma (hPC) is a rare tumor by definition and intracranial hPC makes up to less than one percent of all the intracranial tumors. It is a dural base tumor and its clinical features and radiological findings are similar to meningiomas. however, cerebellopontine angle hemangipericytoma had only been reported twice and would almost always be misdiagnosed. definite diagnosis is important, as the treatment of hPC is different from meningiomas and acoustic neuromas. we report a case of a young female who presented with atypical symptoms of left cerebellopontine angle mass. A literature review of the nature of the disease, radiological findings, immunohistochemical features and treatment options of the tumor are described.

Matched MeSH terms: Meningioma

A case of spinal meningioma

Monteiro ES

Journal of the Malaya Branch of the British Medical Association, 1940;3:410-4.

Matched MeSH terms: Meningioma

Fulltext Radiation-induced meningioma following radiotherapy for pituitary adenonoma: a case report

Ellyda, M.N., Win Mar@Salmah, J.

International Medical Journal Malaysia, 2013;12(1):63-66.

MyJurnal

It is well known that ionizing radiation has an onco-genetic activity and has been implicated in the causation of brain tumors. However, when a new growth appears adjacent to the site of previous tumor, the diagnosis is more toward recurrence. In addition to that, the possible cause might be overlooked, when it occurs many years after radiation treatment. We report a case of radiation-induced meningioma developed 20 years after the patient received radiotherapy for pituitary adenoma.

Matched MeSH terms: Meningioma

Displaying publications 1 - 20 of 54 in total