Displaying publications 1 - 20 of 87 in total

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  1. Fulltext Growing older with HIV in the Treat-All Era
    Rajasuriar R, Crane HM, Semeere AS
    J Int AIDS Soc, 2022 Sep;25 Suppl 4(Suppl 4):e25997.
    PMID: 36176021 DOI: 10.1002/jia2.25997
    Matched MeSH terms: Longevity
  2. Fulltext Crocodiles and alligators: physicians' answer to cancer?
    Khan NA, Soopramanien M, Siddiqui R
    Curr Oncol, 2019 06;26(3):186.
    PMID: 31285664 DOI: 10.3747/co.26.4855
    Matched MeSH terms: Longevity
  3. Tool life of Tia1N PVD coated carbide tool in high-speed end milling of untreated inconel 718 under minimum quantity lubrication condition
    KASIM M, CHE HARON C, GHANI J, GUSRI A, YAZID M, SULAIMAN M
    Sains Malaysiana, 2013;42:1721-1726.
    This paper presents the tool life of the end milled Inconel 718, which is part of a material that is difficult to be machined. Previous researchers found that tool life in machining aged Inconel 718 is shorter compared with other materials. However, this observation required further investigation. Thus, a raw grade Inconel was proposed in this experiment. The experiments were performed using TiAlN-coated carbide. The studied milling parameters were the cutting speed, Vc, from 90 to 150 m/min; feed rate, fz, from 0.15 to 0.25 mm/rev; depth of cut, ap, from 0.3 to 0.5 mm; and radial depth of cut, ae=1 mm. The application of the cutting fluid used in this experiment was a minimum quantity lubricant, which had the advantage of cooling effectiveness and low consumption of cutting fluid. The results showed that the feed rate, fz, was the primary factor controlling the tool life. The combination of Vc=115 m/min, fz=0.15 mm/tooth, as well as ap=0.5 mm and ae=0.15 mm gave the longest tool life that served 95.38 min in operation.
    Matched MeSH terms: Longevity
  4. Fulltext An Energy-Efficient Mobile Sink-Based Unequal Clustering Mechanism for WSNs
    Gharaei N, Abu Bakar K, Mohd Hashim SZ, Hosseingholi Pourasl A, Siraj M, Darwish T
    Sensors (Basel), 2017 Aug 11;17(8).
    PMID: 28800121 DOI: 10.3390/s17081858
    Network lifetime and energy efficiency are crucial performance metrics used to evaluate wireless sensor networks (WSNs). Decreasing and balancing the energy consumption of nodes can be employed to increase network lifetime. In cluster-based WSNs, one objective of applying clustering is to decrease the energy consumption of the network. In fact, the clustering technique will be considered effective if the energy consumed by sensor nodes decreases after applying clustering, however, this aim will not be achieved if the cluster size is not properly chosen. Therefore, in this paper, the energy consumption of nodes, before clustering, is considered to determine the optimal cluster size. A two-stage Genetic Algorithm (GA) is employed to determine the optimal interval of cluster size and derive the exact value from the interval. Furthermore, the energy hole is an inherent problem which leads to a remarkable decrease in the network's lifespan. This problem stems from the asynchronous energy depletion of nodes located in different layers of the network. For this reason, we propose Circular Motion of Mobile-Sink with Varied Velocity Algorithm (CM2SV2) to balance the energy consumption ratio of cluster heads (CH). According to the results, these strategies could largely increase the network's lifetime by decreasing the energy consumption of sensors and balancing the energy consumption among CHs.
    Matched MeSH terms: Longevity
  5. Fulltext Diet Quality of Malaysians across Lifespan: A Scoping Review of Evidence in a Multi-Ethnic Population
    Ramadas A, Tham SM, Lalani SA, Shyam S
    Nutrients, 2021 Apr 20;13(4).
    PMID: 33924050 DOI: 10.3390/nu13041380
    Malaysia is a rapidly developing economy experiencing a nutrition transition. It suffers from a double burden of over- and undernutrition, making it essential to understand diet quality in the population. In this scoping review, we have collated the existing literature on Malaysian diet quality, including factors that influence it, and the association between diet quality and health outcomes across the lifespan of Malaysians. Overall, diet quality was poor in all age groups studied. The Healthy Eating Index (HEI) and its iterations were predominantly used in urban and clinical settings to evaluate diet-chronic disease relationships. These indices were significantly associated with cardio-metabolic and disease risks in adults. The Diet Diversity Score (DDS) and Food Variety Score (FVS) were used to gauge diet quality in maternal and child nutrition studies and were associated with appropriate growth and caloric intake. Deficiencies were found in fruit, vegetable, legumes, and dairy intake. Meat, salt, and sugar intake were found to be excessive in many studies. The findings can inform policies to improve diet quality in this population. The review also identified knowledge gaps that require further investigation.
    Matched MeSH terms: Longevity*
  6. The slow ape: High infant survival and long interbirth intervals in wild orangutans
    van Noordwijk MA, Utami Atmoko SS, Knott CD, Kuze N, Morrogh-Bernard HC, Oram F, et al.
    J Hum Evol, 2018 12;125:38-49.
    PMID: 30502896 DOI: 10.1016/j.jhevol.2018.09.004
    Orangutans (Pongo spp.) are reported to have extremely slow life histories, including the longest average interbirth intervals of all mammals. Such slow life history can be viable only when unavoidable mortality is kept low. Thus, orangutans' survivorship under natural conditions is expected to be extremely high. Previous estimates of orangutan life history were based on captive individuals living under very different circumstances or on small samples from wild populations. Here, we combine birth data from seven field sites, each with demographic data collection for at least 10 years (range 12-43 years) on wild orangutans to better document their life history. Using strict criteria for data inclusion, we calculated infant survival, interbirth intervals and female age at first reproduction, across species, subspecies and islands. We found an average closed interbirth interval of 7.6 years, as well as consistently very high pre-weaning survival for males and females. Female survival of 94% until age at first birth (at around age 15 years) was higher than reported for any other mammal species under natural conditions. Similarly, annual survival among parous females is very high, but longevity remains to be estimated. Current data suggest no major life history differences between Sumatran and Bornean orangutans. The high offspring survival is remarkable, noting that modern human populations seem to have reached the same level of survival only in the 20th century. The orangutans' slow life history illustrates what can be achieved if a hominoid bauplan is exposed to low unavoidable mortality. Their high survival is likely due to their arboreal and non-gregarious lifestyle, and has allowed them to maintain viable populations, despite living in low-productivity habitats. However, their slow life history also implies that orangutans are highly vulnerable to a catastrophic population crash in the face of drastic habitat change.
    Matched MeSH terms: Longevity*
  7. Anti-ageing effects of FDA-approved medicines: a focused review
    Thanapairoje K, Junsiritrakhoon S, Wichaiyo S, Osman MA, Supharattanasitthi W
    J Basic Clin Physiol Pharmacol, 2023 May 01;34(3):277-289.
    PMID: 36631934 DOI: 10.1515/jbcpp-2022-0242
    Ageing is the process generated by senescent cells, free radicals, inflammation and other relevant factors. Ageing contributes to age-related diseases that affect the quality of life. People are interested in anti-ageing intervention and many scientists attempt to search for anti-ageing medicines. This review focused on describing in vivo anti-ageing activity of US-FDA-approved drugs and found that alogliptin, canagliflozin and metformin might produce anti-ageing activity via AMPK activation. Rapamycin and canagliflozin are capable to inhibit mTOR to promote lifespan. Atracurium, carnitine and statins act as DAF-16 activators, which potentially contribute to anti-ageing activity. Hydralazine, lisinopril, rosiglitazone and zidovudine may help stabilize genomic integrity to prolong life expectancy. Other indirect mechanisms, including insulin-lowering effect by acarbose and calcium channel blocking activity by verapamil may also promote longevity. Interestingly, some drugs (i.e., canagliflozin, metformin, rapamycin and acarbose) are likely to demonstrate a lifespan-promoting effect predominantly in male animals. These pre-clinical data might provide mechanistic and phenotypic perspectives to better understand the targets of anti-ageing interventions.
    Matched MeSH terms: Longevity/genetics
  8. Fulltext Patterned Membrane in an Energy-Efficient Tilted Panel Filtration System for Fouling Control in Activated Sludge Filtration
    Osman A, Mat Nawi NI, Samsuri S, Bilad MR, Shamsuddin N, Khan AL, et al.
    Polymers (Basel), 2020 Feb 12;12(2).
    PMID: 32059397 DOI: 10.3390/polym12020432
    A membrane bioreactor enhances the overall biological performance of a conventional activated sludge system for wastewater treatment by producing high-quality effluent suitable for reuse. However, membrane fouling hinders the widespread application of membrane bioreactors by reducing the hydraulic performance, shortening membrane lifespan, and increasing the operational costs for membrane fouling management. This study assesses the combined effect of membrane surface corrugation and a tilted panel in enhancing the impact of air bubbling for membrane fouling control in activated sludge filtration, applicable for membrane bioreactors. The filterability performance of such a system was further tested under variable parameters: Filtration cycle, aeration rate, and intermittent aeration. Results show that a combination of surface corrugation and panel tilting enhances the impact of aeration and leads to 87% permeance increment. The results of the parametric study shows that the highest permeance was achieved under short filtration-relaxation cycle of 5 min, high aeration rate of 1.5 L/min, and short switching period of 2.5 min, to yield the permeances of 465 ± 18, 447 ± 2, and 369 ± 9 L/(m2h bar), respectively. The high permeances lead to higher operational flux that helps to lower the membrane area as well as energy consumption. Initial estimation of the fully aerated system yields the energy input of 0.152 kWh/m3, much lower than data from the full-scale references of <0.4 kWh/m3. Further energy savings and a lower system footprint can still be achieved by applying the two-sided panel with a switching system, which will be addressed in the future.
    Matched MeSH terms: Longevity
  9. Fulltext Development of a Tomography Technique for Assessment of the Material Condition of Concrete Using Optimized Elastic Wave Parameters
    Chai HK, Liu KF, Behnia A, Yoshikazu K, Shiotani T
    Materials (Basel), 2016 Apr 16;9(4).
    PMID: 28773416 DOI: 10.3390/ma9040291
    Concrete is the most ubiquitous construction material. Apart from the fresh and early age properties of concrete material, its condition during the structure life span affects the overall structural performance. Therefore, development of techniques such as non-destructive testing which enable the investigation of the material condition, are in great demand. Tomography technique has become an increasingly popular non-destructive evaluation technique for civil engineers to assess the condition of concrete structures. In the present study, this technique is investigated by developing reconstruction procedures utilizing different parameters of elastic waves, namely the travel time, wave amplitude, wave frequency, and Q-value. In the development of algorithms, a ray tracing feature was adopted to take into account the actual non-linear propagation of elastic waves in concrete containing defects. Numerical simulation accompanied by experimental verifications of wave motion were conducted to obtain wave propagation profiles in concrete containing honeycomb as a defect and in assessing the tendon duct filling of pre-stressed concrete (PC) elements. The detection of defects by the developed tomography reconstruction procedures was evaluated and discussed.
    Matched MeSH terms: Longevity
  10. Fulltext Ergothioneine and its prospects as an anti-ageing compound
    Apparoo Y, Phan CW, Kuppusamy UR, Sabaratnam V
    Exp Gerontol, 2022 Dec;170:111982.
    PMID: 36244584 DOI: 10.1016/j.exger.2022.111982
    Healthy ageing is a crucial process that needs to be highlighted as it affects the quality of lifespan. An increase in oxidative stress along with ageing is the major factor related to the age-associated diseases, especially neurodegenerative disorders. An antioxidant-rich diet has been proven to play a significant role in the ageing process. Targeting ageing mechanisms could be a worthwhile approach to improving health standards. Ergothioneine (EGT), a hydrophilic compound with specific transporter known as OCTN1, has been shown to exert anti-ageing properties. In addition to its antioxidant effect, EGT has been reported to have anti-senescence, anti-inflammatory and anti-neurodegenerative properties. This review aims to define the pivotal role of EGT in major signalling pathways in ageing such as insulin/insulin-like growth factor (IGF) signalling (IIS), sirtuin 6 (SIRT6) and mammalian target of rapamycin complex (mTOR) pathways. The review further discusses evidence of EGT on neurodegeneration in its therapeutic context in various model organisms, providing new insights into improving health. In conclusion, an ergothioneine-rich diet may be beneficial in preventing age-related diseases, resulting in a healthy ageing population.
    Matched MeSH terms: Longevity
  11. Fulltext A systematic review and meta-analysis of the effects of temperature on the development and survival of the Aedes mosquito
    Nik Abdull Halim NMH, Che Dom N, Dapari R, Salim H, Precha N
    Front Public Health, 2022;10:1074028.
    PMID: 36600940 DOI: 10.3389/fpubh.2022.1074028
    INTRODUCTION: The Aedes mosquito species, which are the vectors for the transmission of the dengue virus (DENV) to humans, are becoming increasingly susceptible to the formidable effects of influential factors, especially temperature. However, there are still very few studies that have systematically reviewed the existing literature. Hence, in the present study, a systematic literature review and meta-analysis was conducted into the effects of temperature on dengue vectors.

    METHOD: Several research methodologies were incorporated into the current study, and a review was carried out using PRISMA as a guide. The publications for this study were chosen from two prominent databases, Scopus and Web of Science. All of the studies were assessed, reviewed, and evaluated independently by two reviewers. The meta-analysis tool, Review Manager (RevMan Copenhagen Version 5.4.1), was used to record the extracted data for the meta-analysis. Moran's I 2 and a funnel plot were utilized to measure heterogeneity, and publication bias was investigated. A 95% confidence interval (CI) and overall risk difference (RD) were estimated using a random-effects model.

    RESULT AND DISCUSSION: As a consequence of the search efforts, a total of 46 articles were selected for inclusion in the systematic review and meta-analysis. This review was divided into five major themes, based on a thematic analysis: (i) hatching rate, (ii) development time, (iii) longevity, (iv) survival rate, and (v) wing morphology. In addition, the development time, survival rate, and wing morphology revealed significantly higher risk differences between the maximum and minimum temperatures (RD: 0.26, 95% CI: 0.16, 0.36; p = < 0.00001; RD: 0.10, 95% CI: 0.05, 0.14; p < 0.0001; and RD: 0.07, 95% CI: 0.02, 0.12; p = 0.006, respectively). This study makes several substantial contributions to the body of knowledge and to practical applications. Finally, a number of recommendations are made at the conclusion of this research for the future reference of researchers.

    Matched MeSH terms: Longevity
  12. Fulltext Life-cycle, longevity and fecundity of Blomia tropicalis (Acari: Glycyphagidae) in a tropical laboratory
    Mariana A, Ho TM, Heah SK
    Southeast Asian J. Trop. Med. Public Health, 1996 Jun;27(2):392-5.
    PMID: 9280009
    In the present study on the life-cycle of Blomia tropicalis, freshly laid eggs were observed until they developed into adults; the development periods between stages were recorded. The eggs took an average of 22.9 +/- 6.4 days to develop to adults. For longevity experiments, newly emerged adults were kept at 25 degrees C and observed until they died. There was no significant difference in longevities of the different sexes (p = 0.053). Production of eggs by mated females were monitored until egg production stopped and the female died. Mated females and males survived an average of 32.2 +/- 15.4 and 30.9 +/- 17.7 days respectively. The difference in longevity of the mated females, and males was not significant (p = 0.747). Longevity of the mated females was found to be significantly (p < 0.05) shorter than unmated females.
    Matched MeSH terms: Longevity*
  13. Fulltext Evidence to support cultivated fruiting body of Ophiocordyceps sinensis (Ascomycota)'s role in relaxing airway smooth muscle
    Booi HN, Pang LY, Lee MK, Fung SY, Ng CL, Ng ST, et al.
    J Ethnopharmacol, 2025 Jan 10;336:118727.
    PMID: 39182700 DOI: 10.1016/j.jep.2024.118727
    ETHNOPHARMACOLOGICAL RELEVANCE: Ophiocordyceps sinensis (O. sinensis) is a genus of Ascomycete fungus that is endemic to the alpine meadows of the Tibetan Plateau and adjoining Himalayas. It has been used traditionally as a tonic to improve respiratory health in ancient China as well as to promote vitality and longevity. Bioactive components found in O. sinensis such as adenosine, cordycepin, 3-deoxyadenosine, L-arginine and polysaccharides have gained increasing interest in recent years due to their antioxidative and other properties, which include anti-asthmatic, antiviral, immunomodulation and improvement of general health.

    AIM OF THE STUDY: This study's primary aim was to investigate the effect of a cultivated fruiting body of O. sinensis strain (OCS02®) on airways patency and the secondary focus was to investigate its effect on the lifespan of Caenorhabditis elegans.

    MATERIALS AND METHODS: A cultivated strain, OCS02®, was employed and the metabolic profile of its cold-water extract (CWE) was analysed through liquid chromatography-mass spectrometry (LC-MS). Organ bath approach was used to investigate the pharmacological properties of OCS02® CWE when applied on airway tissues obtained from adult male Sprague-Dawley rats. The airway relaxation mechanisms of OCS02® CWE were explored using pharmacological tools, where the key regulators in airway relaxation and constriction were investigated. For the longevity study, age-synchronised, pos-1 RNAi-treated wild-type type Caenorhabditis elegans at the L4 stage were utilised for a lifespan assay.

    RESULTS: Various glycopeptides and amino acids, particularly a high concentration of L-arginine, were identified from the LC-MS analysis. In airway tissues, OCS02® CWE induced a significantly greater concentration-dependent relaxation when compared to salbutamol. The relaxation response was significantly attenuated in the presence of NG-Nitro-L-arginine methyl ester (L-NAME), 1H-[1,2,4]oxadiazolo [4,3-a]quinoxalin-1-one (ODQ) and several K+ channel blockers. The longevity effect induced by OCS02® CWE (5 mg/mL and above) was observed in C. elegans by at least 17%.

    CONCLUSIONS: These findings suggest that the airway relaxation mechanisms of OCS02® CWE involved cGMP-dependent and cGMP-independent nitric oxide signalling pathways. This study provides evidence that the cultivated strain of OCS02® exhibits airway relaxation effects which supports the traditional use of its wild O. sinensis in strengthening respiratory health.

    Matched MeSH terms: Longevity/drug effects
  14. Fulltext Malaysia's ageing population: challenges in the new millennium
    Arokiasamy JT
    Med J Malaysia, 1999 Dec;54(4):429-32.
    PMID: 11072458
    Matched MeSH terms: Longevity
  15. Fulltext Microstructural, Tribology and Corrosion Properties of Optimized Fe3O4-SiC Reinforced Aluminum Matrix Hybrid Nano Filler Composite Fabricated through Powder Metallurgy Method
    Ashrafi N, Azmah Hanim MA, Sarraf M, Sulaiman S, Hong TS
    Materials (Basel), 2020 Sep 15;13(18).
    PMID: 32942621 DOI: 10.3390/ma13184090
    Hybrid reinforcement's novel composite (Al-Fe3O4-SiC) via powder metallurgy method was successfully fabricated. In this study, the aim was to define the influence of SiC-Fe3O4 nanoparticles on microstructure, mechanical, tribology, and corrosion properties of the composite. Various researchers confirmed that aluminum matrix composite (AMC) is an excellent multifunctional lightweight material with remarkable properties. However, to improve the wear resistance in high-performance tribological application, hardening and developing corrosion resistance was needed; thus, an optimized hybrid reinforcement of particulates (SiC-Fe3O4) into an aluminum matrix was explored. Based on obtained results, the density and hardness were 2.69 g/cm3, 91 HV for Al-30Fe3O4-20SiC, after the sintering process. Coefficient of friction (COF) was decreased after adding Fe3O4 and SiC hybrid composite in tribology behaviors, and the lowest COF was 0.412 for Al-30Fe3O4-20SiC. The corrosion protection efficiency increased from 88.07%, 90.91%, and 99.83% for Al-30Fe3O4, Al-15Fe3O4-30SiC, and Al-30Fe3O4-20SiC samples, respectively. Hence, the addition of this reinforcement (Al-Fe3O4-SiC) to the composite shows a positive outcome toward corrosion resistance (lower corrosion rate), in order to increase the durability and life span of material during operation. The accomplished results indicated that, by increasing the weight percentage of SiC-Fe3O4, it had improved the mechanical properties, tribology, and corrosion resistance in aluminum matrix. After comparing all samples, we then selected Al-30Fe3O4-20SiC as an optimized composite.
    Matched MeSH terms: Longevity
  16. Analysis of Mortality Improvement on the Pension Cost Due to Aging Population
    Rose Irnawaty Ibrahim, Norazmir Mohd Nordin
    MATEMATIKA, 2020;36(3):209-216.
    MyJurnal
    Aging is a good indicator in demographic and health areas as the lifespan
    of the elderly population increases. Based on the government’s Economic Outlook 2019,
    it was found that an aging population would increase the government pension payments
    as the pensioners and their beneficiaries have longer life expectancy. Due to mortality
    rates decreasing over time, the life expectancy tends to increase in the future. The
    aims of this study are to forecast the mortality rates in the years 2020 and 2025 using
    the Heligman-Pollard model and then analyse the effect of mortality improvement on
    the pension cost (annuity factor) for the Malaysian population. However, this study
    only focuses on estimating the annuity factor using life annuities through the forecasted
    mortality rates. The findings indicated that the pension cost is expected to increase if
    the life expectancy of the Malaysian population increases due to the aging population
    the near future. Thus, to reduce pension costs and help the pensioners from insufficient
    financial income, the government needs to consider an extension of the retirement age in
    future.
    Matched MeSH terms: Longevity
  17. Effects of honey and sucrose on longevity and fecundity of Apanteles metesae(Nixon), a major parasitoid of the oil palm bagworm, Metisa plana (Walker)
    Salmah Mohamed, Mohd Basri Wahid, Idris Abd. Ghani
    Sains Malaysiana, 2012;41:1543-1548.
    The effects of various concentrations of honey and sucrose on the longevity and fecundity of Apanteles metesae (Nixon), an endoparasitoid of oil palm bagworm, Metisa plana (Walker) (Lepidoptera: Psychidae) were studied in the laboratory. Our results showed that there were a significant difference (p<0.05) in the longevity of A. metesae fed on various concentrations of honey solutions. Longevity of A. metesae was significantly longer when fed on 50% honey than on pure honey. Nonetheless, longevity of A. metesae females when fed on 50% honey was relatively longer than other honey concentrations. The parasitoid lived significantly longer when fed on 20% sucrose than fed on 50% sucrose and distilled water. However, the parasitoid fed on 50% honey had a longevity that was statistically similar to 20% sucrose and 50% sucrose. Fecundity of A. metesae differed significantly (p<0.05) when fed on 50% honey, 20% sucrose and 50% sucrose. The highest and lowest fecundity was when the parasitoids fed on 20% sucrose and distilled water, respectively. Overall, the result showed that 20% sucrose was a more suitable diet for A. metesae females as compared with other diets.
    Matched MeSH terms: Longevity
  18. Fulltext Life-history constraints, short adult life span and reproductive strategies in coral reef gobies of the genus Trimma
    Goldsworthy NC, Srinivasan M, Smallhorn-West P, Cheah LC, Munday PL, Jones GP
    J Fish Biol, 2022 Oct;101(4):996-1007.
    PMID: 35818109 DOI: 10.1111/jfb.15161
    Body size influences many life-history traits, with small-bodied animals tending to have short life spans, high mortality and greater reproductive effort early in life. In this study, the authors investigated the life-history traits and reproductive strategies of three small-bodied coral reef gobies of the genus Trimma: Trimma benjamini, Trimma capostriatum and Trimma yanoi. The authors found all Trimma species studied attained a small body size of <25 mm, had a short life span of <140 days and experienced high estimated daily mortality of 3.0%-6.7%. Furthermore, the pelagic larval phase accounted for 25.3%-28.5% of the maximum life span, and maturation occurred between 74.1 and 82.1 days at 15.2-15.8 mm, leaving only 35%-43% of the total life span as a reproductively viable adult. All mature individuals had gonad structures consistent with bidirectional sex change, with bisexual gonads including both ovarian and testicular portions separated by a thin wall of connective tissue. In the female and male phases, only ovaries or testes were mature, whereas gonadal tissue of the non-active sex remained. One T. benjamini individual and one T. yanoi individual had ovarian and testicular tissue active simultaneously. The results of this study highlight the life-history challenges small CRFs face on their path to reproduction and reproductive strategies that could be beneficial in fishes with high and unpredictable mortality and short reproductive life spans.
    Matched MeSH terms: Longevity
  19. Fulltext Self-management with alcohol over lifespan: psychological mechanisms, neurobiological underpinnings, and risk assessment
    Müller CP, Schumann G, Rehm J, Kornhuber J, Lenz B
    Mol Psychiatry, 2023 Jul;28(7):2683-2696.
    PMID: 37117460 DOI: 10.1038/s41380-023-02074-3
    Self-management includes all behavioural measures and cognitive activities aimed at coping with challenges arising throughout the lifespan. While virtually all of these challenges can be met without pharmacological means, alcohol consumption has long been instrumentalized as a supporting tool to help coping with problems arising selectively at adolescence, adulthood, and ageing. Here, we present, to our knowledge, the first systematic review of alcohol instrumentalization throughout lifespan. We searched MEDLINE, Google Scholar, PsycINFO and CINAHL (from Jan, 1990, to Dec, 2022) and analysed consumption patterns, goals and potential neurobiological mechanisms. Evidence shows a regular non-addictive use of alcohol to self-manage developmental issues during adolescence, adulthood, and ageing. Alcohol is selectively used to overcome problems arising from dysfunctional personality traits, which manifest in adolescence. A large range of psychiatric disorders gives rise to alcohol use for the self-management of distinct symptoms starting mainly in adulthood. We identify those neuropharmacological effects of alcohol that selectively serve self-management under specific conditions. Finally, we discuss the adverse effects and associated risks that arise from the use of alcohol for self-management. Even well-controlled alcohol use adversely impacts health. Based on these findings, we suggest the implementation of an entirely new view. Health policy action may actively embrace both sides of the phenomenon through a personalized informed use that allows for harm-controlled self-management with alcohol.
    Matched MeSH terms: Longevity
  20. Fulltext Optimization of Micro and Nano Palm Oil Fuel Ash to Determine the Carbonation Resistance of the Concrete in Accelerated Condition
    Tang WL, Lee HS, Vimonsatit V, Htut T, Singh JK, Wan Hassan WNF, et al.
    Materials (Basel), 2019 Jan 03;12(1).
    PMID: 30609786 DOI: 10.3390/ma12010130
    The carbonation rate of reinforced concrete is influenced by three parameters, namely temperature, relative humidity, and concentration of carbon dioxide (CO₂) in the surroundings. As knowledge of the service lifespan of reinforced concrete is crucial in terms of corrosion, the carbonation process is important to study, and high-performance durable reinforced concretes can be produced to prolong the effects of corrosion. To examine carbonation resistance, accelerated carbonation testing was conducted in accordance with the standards of BS 1881-210:2013. In this study, 10⁻30% of micro palm oil fuel ash (mPOFA) and 0.5⁻1.5% of nano-POFA (nPOFA) were incorporated into concrete mixtures to determine the optimum amount for achieving the highest carbonation resistance after 28 days water curing and accelerated CO₂ conditions up to 70 days of exposure. The effect of carbonation on concrete specimens with the inclusion of mPOFA and nPOFA was investigated. The carbonation depth was identified by phenolphthalein solution. The highest carbonation resistance of concrete was found after the inclusion of 10% mPOFA and 0.5% nPOFA, while the lowest carbonation resistance was found after the inclusion of 30% mPOFA and 1.5% nPOFA.
    Matched MeSH terms: Longevity
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