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Fulltext Interleukin-10 (1082G/A) Polymorphism is Associated with Susceptibility of Acute Myeloid Leukemia Patients in Sudanese Population

Sharif OM, Hassan R, Mohammed Basbaeen AA, Mohmed AH, Ibrahim IK

Asian Pac J Cancer Prev, 2019 07 01;20(7):1939-1943.
PMID: 31350948 DOI: 10.31557/APJCP.2019.20.7.1939

Background: Interleukin-10 (IL-10) is a multifunctional cytokine with both immunosuppressive and antiangiogenicfunctions
and may have both tumor-promoting and -inhibiting properties. We examined the association
between a single nucleotide polymorphism (SNP) in IL-10 -1082G/A (rs1800896) in Sudanese acute myeloid leukemia
(AML) patients and to assess the association between polymorphisms in IL-10 -1082G/A (rs1800896) and the
hematological profile in Sudanese patients with AML. Methods: A total of 30 patients with acute myeloid leukemia
and 30 control subjects were enrolled in this study. Blood samples were collected from all patients in EDTA containing
tubes. Genomic DNA was extracted from all blood samples using salting out method. The genotypic variants of
IL-10 (-1082G/A) polymorphism were detected by allele specific-PCR. Results: We found that (36.7%) of patients have
homogenous GG genotype, (43.3%) have heterogeneous GA genotype and (20.0%) have AA genotype. GA genotype
was significantly associated with higher risk of AML compared with the homozygous Genotypes (GG and AA), there is
no association between IL-10 (-1082G/A) polymorphism and AML sub-type, gender, age group, mean of hematological
parameters. Conclusion: Our study concluded that GA genotype of IL-10 -1082G/A (rs1800896) polymorphism is a
risk factor for AML and G allele is insignificantly higher than A allele in AML patient. No association between IL-10
(-1082G/A) polymorphism and AML sub-type, gender, age group, mean of hematological parameters.

Matched MeSH terms: Leukemia, Myeloid, Acute/epidemiology*
Fulltext A case-control study on the association between environmental factors and the occurrence of acute leukemia among children in Klang Valley, Malaysia

Abdul Rahman HI, Shah SA, Alias H, Ibrahim HM

Asian Pac J Cancer Prev, 2008 Oct-Dec;9(4):649-52.
PMID: 19256754

BACKGROUND: In Malaysia, acute leukemia is the most common cancer among children below the age of 15. A case-control study was here conducted for cases from the Klang Valley, Malaysia, who received treatment at the National University of Malaysia Hospital (HUKM) and Kuala Lumpur General Hospital (GHKL). The main objective was to determine any association with environmental factors.

METHODS: Case subjects were children aged below 15 years and diagnosed with acute leukemia in HUKM and GHKL between January 1, 2001 and May 30, 2007. Control subjects were children aged below 15 years who were diagnosed with any non-cancerous acute illnesses in these hospitals. A total of 128 case subjects and 128 control subjects were enrolled in this study. The information was collected using a structured questionnaire and a global positioning system (GPS) device. All factors were analyzed using unmatched logistic regression.

RESULTS: The analysis showed that the occurrence of acute leukemia among children was strongly determined by the following factors: family income (odds ratio (OR) 0.19, 95% confidence interval (CI): 0.09-0.42), father with higher social contact (OR 7.61, 95% CI: 3.78-15.4), number of elder siblings (OR 0.36, 95% CI: 0.18-0.77), father who smokes (OR 2.78, 95% CI: 1.49-5.16), and the distance of the house from a power line (OR 2.30, 95% CI: 1.18-4.49).

CONCLUSIONS: Some socioeconomic, demographic, and environmental factors are strong predictors of the occurrence of acute leukemia among children in Klang Valley, Malaysia. In terms of environmental factors, it is recommended that future housing areas should be developed at least 200 m away from power lines.

Matched MeSH terms: Leukemia, Myeloid, Acute/epidemiology*
Characterisation and Clinical Significance of FLT3-ITD and non-ITD in Acute Myeloid Leukaemia Patients in Kelantan, Northeast Peninsular Malaysia

Yunus NM, Johan MF, Ali Nagi Al-Jamal H, Husin A, Hussein AR, Hassan R

Asian Pac J Cancer Prev, 2015;16(12):4869-72.
PMID: 26163606

BACKGROUND: Mutations of the FMS-like tyrosine kinase-3 (FLT3) receptor gene may promote proliferation via activation of multiple signaling pathways. FLT3-internal tandem duplication (FLT3-ITD) is the most common gene alteration found in patients diagnosed with acute myeloid leukaemia (AML) and has been associated with poor prognosis.
MATERIALS AND METHODS: We performed mutational analysis of exons 14-15 and 20 of the FLT3 gene in 54 AML patients using PCR-CSGE (conformational sensitive gel electrophoresis) followed by sequencing analysis to characterise FLT3 mutations in adult patients diagnosed with AML at Hospital USM, Kelantan, Northeast Peninsular Malaysia.
RESULTS: FLT3 exon 14-15 mutations were identified in 7 of 54 patients (13%) whereas no mutation was found in FLT3 exon 20. Six ITDs and one non-ITD mutation were found in exon 14 of the juxtamembrane (JM) domain of FLT3. FLT3-ITD mutations were associated with a significantly higher blast percentage (p-value=0.008) and white blood cell count (p-value=0.023) but there was no significant difference in median overall survival time for FLT3-ITD+/FLT3-ITD- within 2 years (p-value=0.374).
CONCLUSIONS: The incidence of FLT3-ITD in AML patients in this particular region of Malaysia is low compared to the Western world and has a significant association with WBC and blast percentage.

Matched MeSH terms: Leukemia, Myeloid, Acute/epidemiology
Fulltext Herpes zoster in children with cancer

Menon BS, Wan Maziah WM

Malays J Pathol, 2001 Jun;23(1):47-8.
PMID: 16329548

The aim of this study was to determine the incidence and outcome of herpes zoster hospitalised children with cancer in Kota Baru. It was a retrospective review from January 1994 to December 1998. The diagnosis of herpes zoster was a clinical one. Herpes zoster was diagnosed in 10 of 188 (5%) children with malignancy. The most common malignancy was leukaemia. Nine children were treated with acyclovir. No child developed visceral dissemination and there were no deaths.

Matched MeSH terms: Leukemia, Myeloid, Acute/epidemiology