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HLA DR/DQ type in a Malay population in Kelantan, Malaysia
Azira NM, Zeehaida M, Nurul Khaiza Y
Malays J Pathol
, 2013 Jun;35(1):65-9.
PMID: 23817396
MyJurnal
Abstract
The human leucocyte antigen (
HLA
) has been documented to be involved in various disease susceptibilities or in resistance against certain diseases. An important element in susceptibility and resistance to disease is ethnic genetic constitution. Cognizant of this, the present study aimed at studying the prevalence of particular
HLA
class II in a normal healthy Malay population which may serve as a guide for further genetic and immunological studies related to the Malay Malaysian population. The study involved 40 normal healthy Malay persons in Kelantan.
HLA
typing was conducted on venous
blood
samples through a polymerase chain reaction-sequence specific primer method (low resolution Olerup SSP©
HLA
Typing Kits). The study found
HLA
DR12 and
HLA
DQ8 to be the most frequent
HLA
class II type.
HLA
DQ5 was significantly associated with female subjects.
Matched MeSH terms:
HLA-DR Antigens/blood
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