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  1. Ridley DS, Rea TH, McAdam KP
    Lepr Rev, 1981 Mar;52(1):65-78.
    PMID: 7242219
    Matched MeSH terms: Erythema Nodosum/pathology*
  2. Giam YC, Ong BH, Tan T
    Ann Acad Med Singap, 1987 Oct;16(4):658-62.
    PMID: 3446008
    Erythema Nodosum Leprosum (ENL) or Type II reaction is an immune complex syndrome seen in multibacillary leprosy. 20 patients with histological confirmation of ENL in leprosy were studied from 1982 to 1986. These patients had a range of clinical signs, from fever, tender dusky nodules, bullae, ulcers to lymphadenopathy, arthralgia and neuritis. The four major histological patterns are: a) classical pattern showing heavy infiltrations of neutrophils in three cases, b) sub-epidermal bulla pattern with marked oedema of the upper dermis, and collections of neutrophils in five cases, c) vasculitis pattern, affecting superficial and mid-dermal vessels, leading to epidermal necrosis, bulla formation and ulceration. Dilated vessels, congestion, lumenal fibrin clots and fibrinoid necrosis of vessels were seen, d) non-specific picture in nine cases with mild oedema, infiltration with neutrophils, and two cases with minimal reaction had chronic ENL with clinical vasculitis. All the five cases with vasculitis showed C1q, C3 and fibrinogen in the vessels. Comparing ENL reactions reported in Asia, our pattern is similar to that of Malaysians with the majority showing sub-epidermal oedema. Vasculitis is more common in India. Oedema with collagen necrosis as seen in acute ENL with iritis in New Guinea. The Lucio's phenomenon was not seen in any of the countries in Asia.
    Matched MeSH terms: Erythema Nodosum/pathology*
  3. Yap FB, Lee BR
    Arch Dermatol, 2011 Jun;147(6):735-40.
    PMID: 21690541 DOI: 10.1001/archdermatol.2011.128-a
    Matched MeSH terms: Erythema Nodosum/diagnosis*; Erythema Nodosum/drug therapy; Erythema Nodosum/parasitology*
  4. Yap FB, Kiung ST, Yap JB
    Indian Dermatol Online J, 2016 Jul-Aug;7(4):255-8.
    PMID: 27559497 DOI: 10.4103/2229-5178.185495
    There is a paucity of data on quality of life issues in patients with leprosy suffering from erythema nodosum leprosum (ENL). Thus, we aim to study the effect of ENL on quality of life.
    Matched MeSH terms: Erythema Nodosum
  5. Choon SE, Tey KE
    Int J Dermatol, 2009 Sep;48(9):984-8.
    PMID: 19702985 DOI: 10.1111/j.1365-4632.2009.04078.x
    Lucio's phenomenon is a rare and aggressive necrotising variant of erythema nodosum leprosum that classically occur in patients with undiagnosed, diffuse non-nodular lepromatous leprosy. It is a potentially fatal leprosy reaction characterised by extensive, bizarrely-shaped, painful purpuric skin lesions and ulcerations. Lucio's phenomenon is very rarely reported outside of Mexico and Costa Rica.
    Matched MeSH terms: Erythema Nodosum/pathology*
  6. Jayalakshmi P, Ganesapillai T, Ganesan J
    Int. J. Lepr. Other Mycobact. Dis., 1995 Mar;63(1):109-11.
    PMID: 7730709
    Matched MeSH terms: Erythema Nodosum/pathology*
  7. Ismail NFF, Neoh CF, Lean QY, Abdullah AH, Lim SM, Ramasamy K, et al.
    J Pharm Bioallied Sci, 2018 12 21;10(4):199-207.
    PMID: 30568377 DOI: 10.4103/JPBS.JPBS_33_18
    Aims: Facial candling is one of the traditional treatments that is claimed to be able to help in curing or reducing various allergy and inflammation conditions such as allergic rhinitis. We aimed to explore the perceptions of participants with allergic rhinitis toward their disease conditions and facial candling treatment.

    Materials and Methods: The study used a qualitative exploratory design, comprising 12 in-depth interviews. A semi-structured topic guide was used to explore all relevant aspects of the topic, which were audio recorded, transcribed verbatim. All the interviews were conducted in a few beauty salons in purposively selected city areas in the state of Kedah, Malaysia.

    Results: Of the 12 patients, seven (58%) reported a positive experience of facial candling treatment, with improvement in the condition of their allergic rhinitis. Specific themes about the experience of facial candling treatment that were identified within the transcript data included knowledge about facial candling, options for disease treatment, effectiveness of facial candling, sources of information, comparison, application of treatment, treatment budget, and safety. The major strength lies in the fact that reasons for using facial candling were uncovered from the perspectives of people with allergic rhinitis through the in-depth interviews.

    Conclusions: The motives of these participants for using facial candling are mainly due to cultural influence and its low cost of treatment. There were mixed responses from the participants about the usefulness of facial candling. Most of the respondents had not assessed the safety of prolonged use of facial candling and regarded it as a safe procedure as this has been practiced for generations.

    Matched MeSH terms: Erythema Nodosum
  8. Fuah KW, Lim CTS
    BMC Nephrol, 2017 Jul 24;18(1):249.
    PMID: 28738858 DOI: 10.1186/s12882-017-0666-7
    BACKGROUND: Nephrogenic systemic fibrosis (NSF) is a complication of the gadolinium-based contrast agent used in imaging studies. It is typically characterised by hard, erythematous and indurated skin plaques with surrounding subcutaneous oedema. Distinct papules and subcutaneous nodules can also be seen. Fibrocytes in NSF are immunohistochemically positive for CD34.

    CASE PRESENTATION: We present a case of NSF occurred after gadolinium exposure in which the initial presentation mimics an erythema nodosum (EN)-like picture. An initial skin biopsy showed EN. Subsequently the patient developed progressive skin and joints contracture. A repeated skin biopsy done three months later confirmed the diagnosis of NSF. As far as we are aware, this is the second reported case of NSF that mimicked the presentation of EN in the early phase of the disease.

    CONCLUSIONS: The appearance of EN-like disease can be one of the early manifestations of NSF. We hope that early recognition of this unusual presentation can alert the physician or nephrologist to the potential diagnosis of NSF.

    Matched MeSH terms: Erythema Nodosum/complications*; Erythema Nodosum/diagnosis*
  9. Jayalakshmi
    Malays J Pathol, 1980 Aug;3:39-45.
    PMID: 7186596
    Matched MeSH terms: Erythema Nodosum/pathology
  10. Gelber RH, Waters MF, Pearson JM, Rees RJ, McDougall AC
    Lepr Rev, 1977 Dec;48(4):223-9.
    PMID: 400806
    Matched MeSH terms: Erythema Nodosum/drug therapy
  11. Hobbs HE
    PMID: 4677492
    Matched MeSH terms: Erythema Nodosum/complications; Erythema Nodosum/pathology
  12. Irmi Z, Zaiton A, Faezah H
    Malays Fam Physician, 2013;8(1):24-7.
    PMID: 25606264 MyJurnal
    Reactive arthritis and erythema are uncommon presentations of tuberculosis (TB). Reactive arthritis in tuberculosis (TB) is known as Poncet's disease, a rare aseptic form of arthritis observed in patients with active TB. We report a case of Poncet's disease in a 20-year old man whose reactive arthritis overshadowed other clinical symptoms of TB resulting in delayed diagnosis and treatment. Although a conclusive diagnosis of Poncet's disease is not possible, reactive immunologic reactions such as reactive arthritis and erythema nodosum even without respiratory symptoms should raise suspicion on possible TB. Thus, taking a thorough medical history as well as performing relevant examinations and investigations for possible TB will help expedite the diagnostic process.
    Matched MeSH terms: Erythema Nodosum
  13. Nelson DS, Nelson M, Thurston JM, Waters MF, Pearson JM
    Clin Exp Immunol, 1971 Jul;9(1):33-43.
    PMID: 5559093
    Matched MeSH terms: Erythema Nodosum/immunology
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