Displaying publications 1 - 20 of 562 in total

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  1. Fulltext Reframing non-communicable diseases
    Vijayasingham L, Allotey P
    Lancet Glob Health, 2017 11;5(11):e1070.
    PMID: 29025625 DOI: 10.1016/S2214-109X(17)30326-1
    Matched MeSH terms: Chronic Disease*
  2. Fulltext Editorial: The immunological regulation of extracellular vesicles on chronic diseases
    Wan R, Chen P, Guo S, Zhu J, Mei J, Mai CW, et al.
    Front Immunol, 2024;15:1442387.
    PMID: 38957467 DOI: 10.3389/fimmu.2024.1442387
    Matched MeSH terms: Chronic Disease
  3. Fulltext The chronic care model: Will it work in Malaysia for hypertension?
    Chia YC
    Med J Malaysia, 2013 Apr;68(2):101-2.
    PMID: 23629551
    Matched MeSH terms: Chronic Disease*
  4. Fulltext Managing chronic diseases in the Malaysian primary health care - a need for change
    Ramli AS, Sri Wahyu T
    Malays Fam Physician, 2008;3(1):7-13.
    PMID: 25606105 MyJurnal
    Chronic diseases are the major cause of death and disability in Malaysia, accounted for 71% of all deaths and 69% of the total burden of disease. The WHO in its report Preventing Chronic Disease: A Vital Investment has highlighted the inaction of most governments of the low and middle income countries in tackling the problem urgently, is clear and unacceptable. The acute care paradigm is no longer adequate for the changing pattern of diseases in today's and tomorrow's world. An evolution of primary health care system beyond the acute care model to embrace the concept of caring for long term health problems is imperative in the wake of the rising epidemic of chronic diseases and its crushing burden resulting in escalating healthcare costs. Compelling evidence from around the world showed that there are innovative and cost-effective community-based interventions to reduce the morbidity and mortality attributable to chronic diseases, but these are rarely translated into high quality population-wide chronic disease care. This paper describes the current situation of chronic disease management in the Malaysian primary care setting - to highlight the need for change, discuss the barriers to the implementation of effective chronic disease management programmes in the community, and consider fundamental solutions needed to instigate the change in our setting.
    Matched MeSH terms: Chronic Disease*
  5. Chronic disease and the family physician
    Md Shajahan MY
    Family Physician, 1994;6:1-1.
    Matched MeSH terms: Chronic Disease
  6. Fulltext Healthy lifestyles
    Abdul Razack AH
    JUMMEC, 2007;10(1):1-2.
    MyJurnal
    Healthy lifestyle issues have been very much in the news in both the lay press and the medical journals. The incidence of chronic non-communicable diseases is increasing worldwide and it is no different in Malaysia. Preventing and decreasing the incidence is related to lifestyle issues.
    Matched MeSH terms: Chronic Disease
  7. Fulltext Designing Health Benefits Policies In Malaysia (EnPHC): A Country Assessment Report
    Mohd Saleh N, Nasir NH, Ibrahim NI
    Citation: Mohd Saleh N, Nasir NH, Ibrahim NI. Designing Health Benefits Policies In Malaysia (ENPHC): A Country Assessment Report. Putrajaya: Joint Learning Network for Universal Health Coverage; 2018
    Matched MeSH terms: Chronic Disease
  8. Diversity in the clinical presentation of generalized pustular psoriasis (GPP): A series of case vignettes from around the world
    Choon SE, Elewski BE, Fujita H, Geng S, van de Kerkhof P, Mburu S, et al.
    Exp Dermatol, 2023 Aug;32(8):1284-1295.
    PMID: 36999936 DOI: 10.1111/exd.14794
    A key principle of clinical studies and case reports is that they should reflect the demographics and epidemiology of the patient population concerned. Here, we have compiled a diverse group of clinical cases of generalized pustular psoriasis (GPP) to showcase the differences in GPP presentation in patients worldwide. We attempt to capture the broad spectrum of clinical presentations of GPP and showcase the diversity of the patient population. The patients included in this series are diverse in age, genetic background, skin phototype and medical history. Moreover, they present with a variety of clinical courses of GPP and different degrees of systemic involvement, and experience flares triggered by different inciting factors. The key learnings from this case series may support physicians in identifying and managing patients with this rare and multifaceted disease that can affect patients both physically and psychologically.
    Matched MeSH terms: Chronic Disease
  9. Fulltext Determinants of the demand for using preventive medical care among adults in penang, malaysia
    Cheah YK
    Malays J Med Sci, 2013 Jan;20(1):46-55.
    PMID: 23613658 MyJurnal
    In light of the fact that chronic diseases were becoming more prevalent recently, the primary objective of the study was to examine the socio-demographic, health, and lifestyle determinants of the use of preventive medical care in Penang, Malaysia.
    Matched MeSH terms: Chronic Disease
  10. Fulltext Bacterial Persister Cells and Development of Antibiotic Resistance in Chronic Infections: An Update
    Kunnath AP, Suodha Suoodh M, Chellappan DK, Chellian J, Palaniveloo K
    Br J Biomed Sci, 2024;81:12958.
    PMID: 39170669 DOI: 10.3389/bjbs.2024.12958
    The global issue of antimicrobial resistance poses significant challenges to public health. The World Health Organization (WHO) has highlighted it as a major global health threat, causing an estimated 700,000 deaths worldwide. Understanding the multifaceted nature of antibiotic resistance is crucial for developing effective strategies. Several physiological and biochemical mechanisms are involved in the development of antibiotic resistance. Bacterial cells may escape the bactericidal actions of the drugs by entering a physiologically dormant state known as bacterial persistence. Recent findings in this field suggest that bacterial persistence can be one of the main sources of chronic infections. The antibiotic tolerance developed by the persister cells could tolerate high levels of antibiotics and may give rise to persister offspring. These persister offspring could be attributed to antibiotic resistance mechanisms, especially in chronic infections. This review attempts to shed light on persister-induced antibiotic resistance and the current therapeutic strategies.
    Matched MeSH terms: Chronic Disease
  11. Fulltext Prevalence of chronic illness and health seeking behaviour in Malaysian Population: Results from the Third National Health Morbidity Survey (NHMS III) 2006
    Amal NM, Paramesarvathy R, Tee GH, Gurpreet K, Karuthan C
    Med J Malaysia, 2011 Mar;66(1):36-41.
    PMID: 23765141 MyJurnal
    The third National Health Morbidity Survey was conducted in 2006 on a nationally representative sample of population in Malaysia in order to obtain community-based data and information on the prevalence of chronic illness. Of 57,500 eligible respondents 56710 (98.6%) participated in the study. Estimated overall prevalence of chronic illness in the Malaysian population within a recall period of one year was 15.5% (95% CI 15.1% - 15.9%). Chronic illness was reported significantly higher among the females, 16.8% (16.3 - 17.3). The most common chronic illness was hypertension (7.9%, 7.6 - 8.2), followed by diabetes mellitus (4.0%, 3.8 - 4.2) and highest reported by the Indians (19.7%, 18.4 - 21.0). Among the respondents who had sought treatment for chronic illness from government health facilities, Malays (65.8%) and those with monthly household income of less than RM400 (76.6%) were the highest. Chinese (44.5%) and those with household income of RM5000 and above (54.3%) were the highest groups who sought treatment from the private health facilities. Most of the respondents reported mild illness was the main reason for not seeking treatment for their chronic illness. It is hoped that the results of this survey will help the Ministry of Health Malaysia to enhance health programmes and planning resource allocation in order to improve health status of the population.
    Study name: National Health and Morbidity Survey (NHMS-2006)
    Matched MeSH terms: Chronic Disease*
  12. Rethinking health-care systems: a focus on chronicity
    Allotey P, Reidpath DD, Yasin S, Chan CK, de-Graft Aikins A
    Lancet, 2011 Feb 5;377(9764):450-1.
    PMID: 21074257 DOI: 10.1016/S0140-6736(10)61856-9
    Matched MeSH terms: Chronic Disease/economics*; Chronic Disease/therapy*
  13. Fulltext Suboptimal treatment in chronic diseases--time to go back to basics
    Abdul Rashid AR
    Med J Malaysia, 2008 Aug;63(3):185-7.
    PMID: 19248686
    Matched MeSH terms: Chronic Disease/therapy*
  14. Fulltext Non-communicable diseases in the Asia-Pacific region: Prevalence, risk factors and community-based prevention
    Low WY, Lee YK, Samy AL
    Int J Occup Med Environ Health, 2015;28(1):20-6.
    PMID: 26159943 DOI: 10.2478/s13382-014-0326-0
    Non-communicable diseases (NCDs) lead to substantial mortality and morbidity worldwide. The most common NCDs are cardiovascular diseases (CVD), diabetes, cancer and chronic respiratory diseases. With the rapid increase in NCD-related deaths in Asia Pacific countries, NCDs are now the major cause of deaths and disease burden in the region. NCDs hamper achievement of the Millennium Development Goals (MDG). People in the low socio-economic group are most affected by NCDs as they have poor access to policies, legislations, regulations and healthcare services meant to combat NCDs. This results in loss of productivity by a decreasing labor force with implications at the macroeconomic level. The 3 major NCDs in the Asia Pacific region are CVDs, cancer and diabetes due to the increasing loss of disability adjusted life years (DALYs). The 4 major behavioral risk factors for NCDs are: tobacco use, alcohol consumption, inadequate physical activity and unhealthy diet. The underlying risk factors are urbanization, globalization, sedentary lifestyle, obesity and hypertension. Strategies to combat NCDs in the Asia Pacific region are as follows: population-based dietary salt reduction, health education, psychological interventions, i.e., cognitive behavioral therapy and motivational-interviewing, taxation and bans on tobacco-related advertisements, implementing smoke-free zones and surveillance by the World Health Organization. Control measures must focus on prevention and strengthening inter-sectorial collaboration.
    Matched MeSH terms: Chronic Disease*
  15. Fulltext Developing consensus measures for global programs: lessons from the Global Alliance for Chronic Diseases Hypertension research program
    Riddell MA, Edwards N, Thompson SR, Bernabe-Ortiz A, Praveen D, Johnson C, et al.
    Global Health, 2017 03 15;13(1):17.
    PMID: 28298233 DOI: 10.1186/s12992-017-0242-8
    BACKGROUND: The imperative to improve global health has prompted transnational research partnerships to investigate common health issues on a larger scale. The Global Alliance for Chronic Diseases (GACD) is an alliance of national research funding agencies. To enhance research funded by GACD members, this study aimed to standardise data collection methods across the 15 GACD hypertension research teams and evaluate the uptake of these standardised measurements. Furthermore we describe concerns and difficulties associated with the data harmonisation process highlighted and debated during annual meetings of the GACD funded investigators. With these concerns and issues in mind, a working group comprising representatives from the 15 studies iteratively identified and proposed a set of common measures for inclusion in each of the teams' data collection plans. One year later all teams were asked which consensus measures had been implemented.

    RESULTS: Important issues were identified during the data harmonisation process relating to data ownership, sharing methodologies and ethical concerns. Measures were assessed across eight domains; demographic; dietary; clinical and anthropometric; medical history; hypertension knowledge; physical activity; behavioural (smoking and alcohol); and biochemical domains. Identifying validated measures relevant across a variety of settings presented some difficulties. The resulting GACD hypertension data dictionary comprises 67 consensus measures. Of the 14 responding teams, only two teams were including more than 50 consensus variables, five teams were including between 25 and 50 consensus variables and four teams were including between 6 and 24 consensus variables, one team did not provide details of the variables collected and two teams did not include any of the consensus variables as the project had already commenced or the measures were not relevant to their study.

    CONCLUSIONS: Deriving consensus measures across diverse research projects and contexts was challenging. The major barrier to their implementation was related to the time taken to develop and present these measures. Inclusion of consensus measures into future funding announcements would facilitate researchers integrating these measures within application protocols. We suggest that adoption of consensus measures developed here, across the field of hypertension, would help advance the science in this area, allowing for more comparable data sets and generalizable inferences.

    Matched MeSH terms: Chronic Disease/therapy*
  16. Fulltext Consequences of chronic diseases and other limitations associated with old age - a scoping review
    Maresova P, Javanmardi E, Barakovic S, Barakovic Husic J, Tomsone S, Krejcar O, et al.
    BMC Public Health, 2019 Nov 01;19(1):1431.
    PMID: 31675997 DOI: 10.1186/s12889-019-7762-5
    BACKGROUND: The phenomenon of the increasing number of ageing people in the world is arguably the most significant economic, health and social challenge that we face today. Additionally, one of the major epidemiologic trends of current times is the increase in chronic and degenerative diseases. This paper tries to deliver a more up to date overview of chronic diseases and other limitations associated with old age and provide a more detailed outlook on the research that has gone into this field.

    METHODS: First, challenges for seniors, including chronic diseases and other limitations associated with old age, are specified. Second, a review of seniors' needs and concerns is performed. Finally, solutions that can improve seniors' quality of life are discussed. Publications obtained from the following databases are used in this scoping review: Web of Science, PubMed, and Science Direct. Four independent reviewers screened the identified records and selected relevant publications published from 2010 to 2017. A total of 1916 publications were selected. In all, 52 papers were selected based on abstract content. For further processing, 21 full papers were screened."

    RESULTS: The results indicate disabilities as a major problem associated with seniors' activities of daily living dependence. We founded seven categories of different conditions - psychological problems, difficulties in mobility, poor cognitive function, falls and incidents, wounds and injuries, undernutrition, and communication problems. In order to minimize ageing consequences, some areas require more attention, such as education and training; technological tools; government support and welfare systems; early diagnosis of undernutrition, cognitive impairment, and other diseases; communication solutions; mobility solutions; and social contributions.

    CONCLUSIONS: This scoping review supports the view on chronic diseases in old age as a complex issue. To prevent the consequences of chronic diseases and other limitations associated with old age related problems demands multicomponent interventions. Early recognition of problems leading to disability and activities of daily living (ADL) dependence should be one of essential components of such interventions.

    Matched MeSH terms: Chronic Disease/epidemiology*
  17. Real-Time Remote-Health Monitoring Systems: a Review on Patients Prioritisation for Multiple-Chronic Diseases, Taxonomy Analysis, Concerns and Solution Procedure
    Mohammed KI, Zaidan AA, Zaidan BB, Albahri OS, Alsalem MA, Albahri AS, et al.
    J Med Syst, 2019 Jun 11;43(7):223.
    PMID: 31187288 DOI: 10.1007/s10916-019-1362-x
    Remotely monitoring a patient's condition is a serious issue and must be addressed. Remote health monitoring systems (RHMS) in telemedicine refers to resources, strategies, methods and installations that enable doctors or other medical professionals to work remotely to consult, diagnose and treat patients. The goal of RHMS is to provide timely medical services at remote areas through telecommunication technologies. Through major advancements in technology, particularly in wireless networking, cloud computing and data storage, RHMS is becoming a feasible aspect of modern medicine. RHMS for the prioritisation of patients with multiple chronic diseases (MCDs) plays an important role in sustainably providing high-quality healthcare services. Further investigations are required to highlight the limitations of the prioritisation of patients with MCDs over a telemedicine environment. This study introduces a comprehensive and inclusive review on the prioritisation of patients with MCDs in telemedicine applications. Furthermore, it presents the challenges and open issues regarding patient prioritisation in telemedicine. The findings of this study are as follows: (1) The limitations and problems of existing patients' prioritisation with MCDs are presented and emphasised. (2) Based on the analysis of the academic literature, an accurate solution for remote prioritisation in a large scale of patients with MCDs was not presented. (3) There is an essential need to produce a new multiple-criteria decision-making theory to address the current problems in the prioritisation of patients with MCDs.
    Matched MeSH terms: Chronic Disease*
  18. Pathogenesis of epilepsy: challenges in animal models
    Hui Yin Y, Ahmad N, Makmor-Bakry M
    Iran J Basic Med Sci, 2013 Nov;16(11):1119-32.
    PMID: 24494063
    Epilepsy is one of the most common chronic disorders affecting individuals of all ages. A greater understanding of pathogenesis in epilepsy will likely provide the basis fundamental for development of new antiepileptic therapies that aim to prevent the epileptogenesis process or modify the progression of epilepsy in addition to treatment of epilepsy symptomatically. Therefore, several investigations have embarked on advancing knowledge of the mechanism underlying epileptogenesis, understanding in mechanism of pharmacoresistance and discovering antiepileptogenic or disease-modifying therapy. Animal models play a crucial and significant role in providing additional insight into mechanism of epileptogenesis. With the help of these models, epileptogenesis process has been demonstrated to be involved in various molecular and biological pathways or processes. Hence, this article will discuss the known and postulated mechanisms of epileptogenesis and challenges in using the animal models.
    Matched MeSH terms: Chronic Disease
  19. Fulltext The cost reduction in hospitalization associated with paliperidone palmitate in the People's Republic of China, Korea, and Malaysia
    Chiou CF, Wang BC, Caldwell R, Furnback W, Lee JS, Kothandaraman N, et al.
    Neuropsychiatr Dis Treat, 2015;11:1989-94.
    PMID: 26346330 DOI: 10.2147/NDT.S86722
    Schizophrenia results in substantial health care utilization costs. Much of these costs can be attributed to health care use resulting from nonadherence to treatment, relapse, and hospitalization.
    Matched MeSH terms: Chronic Disease
  20. METOPROLOL SUCCINATE: GENETIC ASPECTS OF INDIVIDUAL SENSITIVITY AND EFFICACY IN PATIENTS WITH OBESITY AND CHRONIC HEART FAILURE
    Gasanov I, Rudyk Y
    Georgian Med News, 2019 Jan.
    PMID: 30829590
    Aim - optimization of the treatment of obesity and chronic heart failure (CHF) patients by identifying key factors for the progression of cardiac decompensation and the principles of using metoprolol succinate, taking into account pharmacogenetic aspects in the complex treatment of this comorbidity. 127 patients with CHF 2nd-3rd stages, 1st-4th functional class by New York Heart Association at the age of 32-87 (61 [57; 65]) years were examined, including 93 men and 34 women. A comparative analysis of certain clinical criteria using the sequential analysis of Wald A.A. The results were statistically plausible with p<0.05. Conducting factor analysis allowed to separate groups of indicators and estimate the specific weight of individual factors in the pathogenesis of combined pathology - obesity and heart failure. The first two factors determine 76.8% of the variability of the indicators, given the indicators that load them, they were given descriptive titles "clinical-hemodynamic factor", "clinical and anthropometric factor". The proposed prognostic protocol provides new possibilities for predicting the efficacy of metoprolol succinate in patients with obesity and chronic heart failure. The developed discriminatory models allow to objectify the criteria for determining the doses of metoprolol succinate in patients with obesity and chronic heart failure - the maximum initial, maximal endpoint, and also to evaluate the expediency of a subsequent stepwise increase in dose. Perspective of further studies - development and clinical approbation of the protocol of the use of metoprolol succinate in patients with CHF in the context of obesity, taking into account the results of the conducted factor analysis and developed prognostic means.
    Matched MeSH terms: Chronic Disease
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