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  1. Fulltext Dermatoglyphic analysis in Malay subjects with bipolar mood disorder
    Chakraborty D, Mazumdar P, Than M, Singh R
    Med J Malaysia, 2001 Jun;56(2):223-6.
    PMID: 11771083
    Dermatoglyphic is the study of the epidermal ridges and the pattern formed by them. It may be pointed out that genetic factors have a large share in determining the variations in dermatoglyphics. It is however, suggested by evidence that bipolar mood disorder factors are determined more by genetic factors than by the environmental factors. The experiment has been undertaken to look for the effects of the bipolar mood disorder on dermatoglyphics. The dermatoglyphic characteristics of subjects with bipolar mood disorder when compared with control group revealed significant differences. The radial loop were increased in bipolar mood disorder, but there were little changes in 'atd' angles between normal and bipolar mood disorder.
    Matched MeSH terms: Bipolar Disorder/etiology; Bipolar Disorder/genetics*; Bipolar Disorder/pathology*
  2. Is increased libido an atypical symptom of bipolar depression? An interesting case
    Mahadevan R, Nik Jaafar NR, Sidi H, Midin M, Das S
    J Sex Med, 2013 Mar;10(3):883-6.
    PMID: 23036068 DOI: 10.1111/j.1743-6109.2012.02949.x
    Decreased libido is recognized as one of the vegetative symptoms of depression. Increased libido has not been acknowledged as one of its symptoms, neither has it been reported, particularly in depressed bipolar patients.
    Matched MeSH terms: Bipolar Disorder/drug therapy; Bipolar Disorder/psychology*
  3. Post-electrocution persistent manic-depressive syndrome: a unique diagnostic syndrome and a red flag against electroconvulsive therapy?
    Nahdiya S, Syukri C
    Med J Malaysia, 2018 12;73(6):441-442.
    PMID: 30647228
    Bipolar mood disorder is an established psychiatric disorder affecting 1% of the population and it is a highly disabling disease. As of today, its aetiology is still a confounding question. This case is interesting as the patient presented with a full-blown mania after suffering from electrical injury. The persistent syndrome in this case could point to a unique diagnostic entity and offer possible explanation of the pathophysiology of manic depressive as well as a consideration for caution when prescribing electroconvulsive therapy (ECT).
    Matched MeSH terms: Bipolar Disorder/diagnosis; Bipolar Disorder/etiology*
  4. Fulltext Late onset mania post dengue fever in an elderly patient: a case report
    Tengku Mohd Saifuddin, Aida Farina Ismail, Noorul Amilin Harun
    Malaysian Journal of Psychiatry, 2018;27(1):0-0.
    MyJurnal
    Manic symptoms secondary to post dengue fever are rare or might be underreported. Awareness of this phenomenon is important for therapeutic
    considerations of patients. We present a case of late onset mania in an elderly
    gentleman who developed manic symptoms post dengue fever.
    Matched MeSH terms: Bipolar Disorder
  5. Fulltext What can we learn from the Canadian Network for Mood and Anxiety Treatments (CANMAT) Guidelines?
    Mohd Ridzwan, J., Rafidah, B.
    Malaysian Journal of Psychiatry, 2011;20(1):1-4.
    MyJurnal
    Bipolar Mood Disorder (BMD) is one of the most common, severe, and persistent mental illnesses. The Malaysian Consensus Statement for the Treatment of Bipolar Mood Disorder, published in 2007 is still the major reference for managing the condition in this country. However, recently the Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines was revised and at the moment, this contains the most up-to-date recommendations. This paper reviewed and compared both documents to establish the latest information on managing Bipolar Mood Disorder.
    Matched MeSH terms: Bipolar Disorder
  6. Fulltext Psychotherapy and pharmacotherapy in anxiety disorders
    Azhar, M.Z.
    Malaysian Journal of Psychiatry, 2006;14(1):1-2.
    MyJurnal
    Anxiety Disorders have been said to account for the majority of psychiatric cases treated in out patient clinics all over the world. However not much input Is being given to it in the teaching of futufe doctors mainly because although it is common it is not generally seen by students posted to psychiatry wards in Malaysia. The students have the advantage of visiting patients in the wards daily but may only spend about 20% of the entire psychiatry posting in the clinics. As such, emphasis in identifying and treating anxiety disorders becomes diminished. More time is spent on discussing management issues of schizophrenia and bipolar disorders when the likelihood of students treating anxiety disorders in primary care and family physician clinics are more after they graduate. This short editorial looks at the current trend in combining psychotherapy and pharmacotherapy in anxiety pathology for the benefit of both practicing doctors and students.
    Matched MeSH terms: Bipolar Disorder
  7. International multi-site survey on the use of online support groups in bipolar disorder
    Bauer R, Conell J, Glenn T, Alda M, Ardau R, Baune BT, et al.
    Nord J Psychiatry, 2017 Aug;71(6):473-476.
    PMID: 28696841 DOI: 10.1080/08039488.2017.1334819
    BACKGROUND: Peer support is an established component of recovery from bipolar disorder, and online support groups may offer opportunities to expand the use of peer support at the patient's convenience. Prior research in bipolar disorder has reported value from online support groups.

    AIMS: To understand the use of online support groups by patients with bipolar disorder as part of a larger project about information seeking.

    METHODS: The results are based on a one-time, paper-based anonymous survey about information seeking by patients with bipolar disorder, which was translated into 12 languages. The survey was completed between March 2014 and January 2016 and included questions on the use of online support groups. All patients were diagnosed by a psychiatrist. Analysis included descriptive statistics and general estimating equations to account for correlated data.

    RESULTS AND CONCLUSIONS: The survey was completed by 1222 patients in 17 countries. The patients used the Internet at a percentage similar to the general public. Of the Internet users who looked online for information about bipolar disorder, only 21.0% read or participated in support groups, chats, or forums for bipolar disorder (12.8% of the total sample). Given the benefits reported in prior research, clarification of the role of online support groups in bipolar disorder is needed. With only a minority of patients using online support groups, there are analytical challenges for future studies.

    Matched MeSH terms: Bipolar Disorder/epidemiology; Bipolar Disorder/psychology*; Bipolar Disorder/therapy*
  8. Electroconvulsive therapy in a 91-year old Asian lady with late onset bipolar mania
    Francis B, Petrus CF, Wong HH
    Asian J Psychiatr, 2020 Apr;50:101986.
    PMID: 32135484 DOI: 10.1016/j.ajp.2020.101986
    BACKGROUND: Electroconvulsive therapy (ECT) is safe and efficacious in the elderly population. However, clinicians are still weary to use it among the old-old population, citing safety concerns. Our case report highlights the use of ECT in a 91 year old lady with late onset Bipolar Mania.

    CASE REPORT: A 91 year old lady presented with an acute manic relapse for the past 2 weeks. She was previously on oral Sodium Valproate, and during this current admission was augmented with oral Quetiapine IR 100 mg bd. She remained unwell and was planned for right unilateral ECT with age-based dosing stimuli. After only 4 sessions, she showed complete resolution of her manic symptoms.

    RESULT: In our case study, the patient showed rapid response to right unilateral ECT. Even though the Post Suppression Index (PSI) was not significant, there is some evidence that in elderly patients, burst suppression (not measured in this case) may be more accurate measure of ECT efficacy. The transient treatment emergent delirium was short lived and ECT was very tolerated in this patient.

    CONCLUSION: Clinicians should not delay ECT in old-old patients who do not respond to pharmacologic treatment, as early switch to ECT results in rapid response with good safety profile.

    Matched MeSH terms: Bipolar Disorder/therapy*
  9. Relationship between sunlight and the age of onset of bipolar disorder: an international multisite study
    Bauer M, Glenn T, Alda M, Andreassen OA, Angelopoulos E, Ardau R, et al.
    J Affect Disord, 2014;167:104-11.
    PMID: 24953482 DOI: 10.1016/j.jad.2014.05.032
    The onset of bipolar disorder is influenced by the interaction of genetic and environmental factors. We previously found that a large increase in sunlight in springtime was associated with a lower age of onset. This study extends this analysis with more collection sites at diverse locations, and includes family history and polarity of first episode.
    Matched MeSH terms: Bipolar Disorder/etiology*; Bipolar Disorder/genetics; Bipolar Disorder/epidemiology*
  10. Fulltext Executive function and attention span in euthymic patients with bipolar 1 disorder
    Normala I, Abdul HA, Azlin B, Nik Ruzyanei NJ, Hazli Z, Shah SA
    Med J Malaysia, 2010 Sep;65(3):199-203.
    PMID: 21939168
    This is a cross sectional comparison study to assess executive function and attention span in euthymic patients with bipolar 1 disorder. It compares the performance of these two cognitive domains in 40 patients with bipolar 1 disorder to that of 40 healthy normal subjects using Trail Making (TMT), Digit Span (Forward and Backward) and Verbal Fluency (VF) tests. The association between demographic, clinical characteristics and performance in all tests were examined. Patients with bipolar illness showed significant impairment with moderate to large effect sizes (VF = 0.67, TMT A = 0.52, TMT B = 0.81, Digit Forward = 0.97, Digit backward = 1.10) in all tasks of executive and attention functioning. These impairments are observed in the absence of active mood symptoms while duration and severity of illness are not found to have an effect on both cognitive domains. Medications received by patients with bipolar disorder have significant association with performance on executive tasks. The results of this study add on to the existing global evidence of cognitive impairment in bipolar illness despite its cross cultural differences. Its presence in the absence of mania, depression or mixed episode indicates that cognitive impairment is stable even after symptoms recovery.
    Matched MeSH terms: Bipolar Disorder/complications*; Bipolar Disorder/drug therapy; Bipolar Disorder/psychology
  11. Fulltext Electrical Conductivity Performance of Predicted Modified Fibre Contact Model for Multi-Filler Polymer Composite
    Mohd Radzuan NA, Sulong AB, Hui D, Verma A
    Polymers (Basel), 2019 Aug 30;11(9).
    PMID: 31480276 DOI: 10.3390/polym11091425
    Polymer composites have been extensively fabricated given that they are well-fitted for a variety of applications, especially concerning their mechanical properties. However, inadequate outcomes, mainly regarding their electrical performance, have limited their significant potential. Hence, this study proposed the use of multiple fillers, with different geometries, in order to improve the electrical conductivity of a polymer composite. The fabricated composite was mixed, using the ball milling method, before being compressed by a hot press machine at 3 MPa for 10 min. The composite plate was then measured for both its in-plane and through-plane conductivities, which were 3.3 S/cm, and 0.79 S/cm, respectively. Furthermore, the experimental data were then verified using a predicted electrical conductivity model, known as a modified fibre contact model, which considered the manufacturing process, including the shear rate and flow rate. The study indicated that the predicted model had a significant trend and value, compared to the experimental model (0.65 S/cm for sample S1). The resultant fabricated composite materials were found to possess an excellent network formation, and good electrical conductivity for bipolar plate application, when applying compression pressure of 3 MPa for 10 min.
    Matched MeSH terms: Bipolar Disorder
  12. Fulltext Roles of primary care physicians in managing bipolar disorders in adults
    Awaluddin A, Jali N, Bahari R, Jamil Z, Haron N
    Malays Fam Physician, 2015;10(3):27-31.
    PMID: 27570605 MyJurnal
    Management of bipolar disorder (BD) is challenging due to its multiple and complex facets of presentations as well as various levels of interventions. There is also limitation of treatment accessibility especially at the primary care level. Local evidence-based clinical practice guidelines address the importance of integrated care of BD at various levels. Primary care physicians hold pertinent role in maintaining remission and preventing relapse by providing systematic monitoring of people with BD. Pharmacological treatment in particular mood stabilisers remain the most effective management with psychosocial interventions as adjunct. This paper highlights the role of primary care physicians in the management of BD.
    Matched MeSH terms: Bipolar Disorder
  13. Fulltext The effectiveness of paliperidone for adolescents with atypical presentation of bipolar disorder in manic phase: a case report
    Norzila Zakaria, Mohd Jamil Yaacob, Hans, Van Rostenberghe
    ASEAN Journal of Psychiatry, 2009;10(2):199-201.
    MyJurnal
    Objective: To report the use of Paliperidone in an adolescent with bipolar disorder primarily concerning its effectiveness and safety. Method: We present a case report of an adolescent with atypical presentation of bipolar disorder. The problem was complicated by poor liver function and poor compliance. Progress of the patient was recorded. Results: The patient showed dramatic improvement after 2 weeks on Paliperidone and has achieved the best level of functioning after almost 4 years on other treatment. Conclusion: The usage of Paliperidone was effective and safe in an adolescent with atypical bipolar disorder.
    Matched MeSH terms: Bipolar Disorder
  14. Manic-Depressive Psychosis (MDP): Western and Islamic approach
    Alias J, Mat N
    Jurnal Psikologi Malaysia, 2011;olume 25:22-25.
    Personal ups and downs are appropriate responses to the ups and downs of life. However, some experiences emotional extremes in moods and disturbed their normal life. Individuals who have depression at times and mania or hypomania at others are called manic-depressive; and the combination is known as manic-depressive psychosis (MDP). This paper attempts to look at manic-depressive psychosis (MDP) from the western approaches as well as from the Islamic point of view. The treatments proposed by both streams are also provided.
    Matched MeSH terms: Bipolar Disorder
  15. Fulltext Global biogeographic patterns in bipolar moss species
    Biersma EM, Jackson JA, Hyvönen J, Koskinen S, Linse K, Griffiths H, et al.
    R Soc Open Sci, 2017 Jul;4(7):170147.
    PMID: 28791139 DOI: 10.1098/rsos.170147
    A bipolar disjunction is an extreme, yet common, biogeographic pattern in non-vascular plants, yet its underlying mechanisms (vicariance or long-distance dispersal), origin and timing remain poorly understood. Here, combining a large-scale population dataset and multiple dating analyses, we examine the biogeography of four bipolar Polytrichales mosses, common to the Holarctic (temperate and polar Northern Hemisphere regions) and the Antarctic region (Antarctic, sub-Antarctic, southern South America) and other Southern Hemisphere (SH) regions. Our data reveal contrasting patterns, for three species were of Holarctic origin, with subsequent dispersal to the SH, while one, currently a particularly common species in the Holarctic (Polytrichum juniperinum), diversified in the Antarctic region and from here colonized both the Holarctic and other SH regions. Our findings suggest long-distance dispersal as the driver of bipolar disjunctions. We find such inter-hemispheric dispersals are rare, occurring on multi-million-year timescales. High-altitude tropical populations did not act as trans-equatorial 'stepping-stones', but rather were derived from later dispersal events. All arrivals to the Antarctic region occurred well before the Last Glacial Maximum and previous glaciations, suggesting that, despite the harsh climate during these past glacial maxima, plants have had a much longer presence in this southern region than previously thought.
    Matched MeSH terms: Bipolar Disorder
  16. Serotonin transporter gene polymorphism and its association with bipolar disorder across different ethnic groups in Malaysia
    Mohamed Saini S, Nik Jaafar NR, Sidi H, Midin M, Mohd Radzi A, Abdul Rahman AH
    Compr Psychiatry, 2014 Jan;55 Suppl 1:S76-81.
    PMID: 23410635 DOI: 10.1016/j.comppsych.2012.12.005
    The risk variants have been shown to vary substantially across populations and a genetic study in a heterogeneous population might shed a new light in the disease mechanism. This preliminary study aims to determine the frequency of the serotonin transporter gene polymorphism (5-HTTLPR) in the three main ethnic groups in Malaysia and its association with bipolar disorder.
    Matched MeSH terms: Bipolar Disorder/ethnology; Bipolar Disorder/genetics*
  17. Reduced red-cell folate in mania
    Hasanah CI, Khan UA, Musalmah M, Razali SM
    J Affect Disord, 1997 Nov;46(2):95-9.
    PMID: 9479613
    Forty-five hospitalised patients with DSM-III-R diagnosis of mania, were found to have a mean red-cell folate level of 193 nmol/l, as compared to 896 nmol/l in the control group (P < 0.00001). Assessment of serum folate in both groups showed no significant differences in the levels. Furthermore the manic patients and the controls were matched by the socio-economic status. This indicated that the reduced red-cell folate in mania is associated with the illness and not due to reduced absorption or dietary deficiency of folate. Considering previous studies that showed reduced red-cell folate in depression, our findings suggest that reduced red-cell folate occurred in both phases of bipolar disorders.
    Matched MeSH terms: Bipolar Disorder/blood*; Bipolar Disorder/diagnosis
  18. Preliminary examination of microRNA expression profiling in bipolar disorder I patients during antipsychotic treatment
    Lim CH, Zainal NZ, Kanagasundram S, Zain SM, Mohamed Z
    Am J Med Genet B Neuropsychiatr Genet, 2016 09;171(6):867-74.
    PMID: 27177356 DOI: 10.1002/ajmg.b.32457
    Although major progress has been achieved in research and development of antipsychotic medications for bipolar disorder (BPD), knowledge of the molecular mechanisms underlying this disorder and the action of atypical antipsychotics remains incomplete. The levels of microRNAs (miRNAs)-small non-coding RNA molecules that regulate gene expression, including genes involved in neuronal function and plasticity-are frequently altered in psychiatric disorders. This study aimed to examine changes in miRNA expression in bipolar mania patients after treatment with asenapine and risperidone. Using a miRNA microarray, we analyzed miRNA expression in the blood of 10 bipolar mania patients following 12 weeks of treatment with asenapine or risperidone. Selected miRNAs were validated by using real-time PCR. A total of 16 miRNAs were differentially expressed after treatment in the asenapine group, 14 of which were significantly upregulated and the other two significantly downregulated. However, all three differentially expressed miRNAs in the risperidone group were downregulated. MiRNA target gene prediction and gene ontology analysis revealed significant enrichment for pathways associated with immune system response and regulation of programmed cell death and transcription. Our results suggest that candidate miRNAs may be involved in the mechanism of action of both antipsychotics in bipolar mania. © 2016 Wiley Periodicals, Inc.
    Matched MeSH terms: Bipolar Disorder/genetics*; Bipolar Disorder/metabolism
  19. Internet use by patients with bipolar disorder: Results from an international multisite survey
    Bauer R, Conell J, Glenn T, Alda M, Ardau R, Baune BT, et al.
    Psychiatry Res, 2016 08 30;242:388-394.
    PMID: 27391371 DOI: 10.1016/j.psychres.2016.05.055
    There is considerable international interest in online education of patients with bipolar disorder, yet little understanding of how patients use the Internet and other sources to seek information. 1171 patients with a diagnosis of bipolar disorder in 17 countries completed a paper-based, anonymous survey. 81% of the patients used the Internet, a percentage similar to the general public. Older age, less education, and challenges in country telecommunications infrastructure and demographics decreased the odds of using the Internet. About 78% of the Internet users looked online for information on bipolar disorder or 63% of the total sample. More years of education in relation to the country mean, and feeling very confident about managing life decreased the odds of seeking information on bipolar disorder online, while having attended support groups increased the odds. Patients who looked online for information on bipolar disorder consulted medical professionals plus a mean of 2.3 other information sources such as books, physician handouts, and others with bipolar disorder. Patients not using the Internet consulted medical professionals plus a mean of 1.6 other information sources. The percentage of patients with bipolar disorder who use the Internet is about the same as the general public. Other information sources remain important.
    Matched MeSH terms: Bipolar Disorder/epidemiology*; Bipolar Disorder/psychology*
  20. Fulltext Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
    Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium. Electronic address: [email protected], Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium
    Cell, 2018 Jun 14;173(7):1705-1715.e16.
    PMID: 29906448 DOI: 10.1016/j.cell.2018.05.046
    Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology. Understanding the genetic factors contributing to the shared and disorder-specific symptoms will be crucial for improving diagnosis and treatment. In genetic data consisting of 53,555 cases (20,129 bipolar disorder [BD], 33,426 schizophrenia [SCZ]) and 54,065 controls, we identified 114 genome-wide significant loci implicating synaptic and neuronal pathways shared between disorders. Comparing SCZ to BD (23,585 SCZ, 15,270 BD) identified four genomic regions including one with disorder-independent causal variants and potassium ion response genes as contributing to differences in biology between the disorders. Polygenic risk score (PRS) analyses identified several significant correlations within case-only phenotypes including SCZ PRS with psychotic features and age of onset in BD. For the first time, we discover specific loci that distinguish between BD and SCZ and identify polygenic components underlying multiple symptom dimensions. These results point to the utility of genetics to inform symptomology and potential treatment.
    Matched MeSH terms: Bipolar Disorder/genetics*; Bipolar Disorder/pathology
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