MyMedR

Metachromatic ground substance of normal aortic media at different ages in Chinese subjects

MUMTAZUDDIN AHMED M, MOHIUDDIN A

Med J Malaya, 1963 Mar;17:199-208.

PMID: 13936588

Matched MeSH terms: Aorta*

Fulltext Anti-senescence effects of 4-methoxychalcone and 4-bromo-4'-methoxychalcone on human endothelial cells

Tien XY, Lee YK, Wong PF, Khor YS, Murugan DD, Abdullah I

Drug Discov Ther, 2024;18(3):199-206.

PMID: 38987208 DOI: 10.5582/ddt.2024.01034

Senolytics are drugs that specifically target senescent cells. Flavonoids such as quercetin and fisetin possess selective senolytic activities. This study aims to investigate if chalcones exhibit anti-senescence activities. Anti-senescence effect of 11 chalcone derivatives on the replicative senescence human aortic endothelial cells (HAEC) and human fetal lung fibroblasts (IMR90) was evaluated. Compound 2 (4-methoxychalcone) and compound 4 (4-bromo-4'-methoxychalcone) demonstrated increased cytotoxicity in senescent HAEC compared to young HAEC, with significant differences on IC50 values. Their anti-senescence effects on HAEC exceeded fisetin. Higher selectivity of compound 4 toward HAEC over IMR90 could be attributed to 4-methoxy (4-OMe) substitution at ring A (R1). Chalcone derivatives have potentials as senolytics in mitigating replicative senescence, warranting further research and development on chalcones as anti-senescent agent.

Matched MeSH terms: Aorta/cytology; Aorta/drug effects

Fulltext ST elevation in lead aVR with malperfusion syndrome: sign of severe aortic dissection

Abd Samat, A.H., Ida, Z.Z., Yat, Keong Y., Isa, M.H.

Medicine & Health, 2020;15(2):297-305.

MyJurnal

Kenaikan segmen ST di elektrod aVR elektrokardiografi di dalam kes diseksi aorta mempunyai risiko kematian yang tinggi. Ia melibatkan diseksi yang berlaku di akar aorta. Kami melaporkan kes pesakit lelaki muda yang menghidap penyakit darah tinggi, yang datang ke Jabatan Kecemasan dengan sakit dada dan sakit di bahagian kaki. Pemeriksaan fizikal pada bahagian bawah kiri anggota adalah konsisten dengan iskemia akut. Elektrokardiogram menunjukkan serangan jantung akut di bahagian elektrod anterolateral, dan kenaikan ST segmen di elektrod aVR. Ekokardiografi menunjukkan akar aorta yang berukuran 4.51 cm dan kehadiran flap intimal, meningkatkan kebarangkalian diseksi pada akar aorta dan arteri koronari. Tomography Computed Angiogram menunjukkan terdapat diseksi aorta dari akar aorta termasuk flap intimal berhampiran permulaan arteri koronari kiri, hingga ke arteri iliac utama ke arteri iliac kiri. Malangnya, pesakit memilih untuk tidak menjalani pembedahan dan akhirnya meninggal dunia selepas 48 jam di masukkan ke wad. Kes ini menjelaskan bahawa, dalam kes diseksi aorta yang hadir dengan sindrom 'malperfusion', kenaikan segmen ST pada elektrod aVR akan meningkatkan kebarangkalian terjadinya diseksi aorta yang teruk melibatkan akar aorta dan juga arteri koronari, yang menjadikan prognosis pesakit lebih teruk.

Matched MeSH terms: Aorta

Transesophageal Echocardiography at the Golden Hour: Identification of Blunt Traumatic Aortic Injuries in the Emergency Department

Osman A, Fong CP, Wahab SFA, Panebianco N, Teran F

J Emerg Med, 2020 Sep;59(3):418-423.

PMID: 32591302 DOI: 10.1016/j.jemermed.2020.05.003

BACKGROUND: Although surface sonography has become an essential diagnostic tool in the evaluation of trauma patients, important limitations of this modality include the evaluation of retroperitoneal hemorrhage and mediastinal pathology, such as blunt traumatic aortic injuries (BTAI). As in other emergency applications where surface sonography can't provide the information needed, focused transesophageal echocardiography (TEE) may represent a valuable diagnostic tool in the evaluation of hemodynamically unstable trauma patients with suspected thoracic pathology such as BTAI.

CASE SERIES: We present a series of five cases that illustrate the diagnostic value of emergency physician-performed resuscitative TEE in the diagnosis of BTAI in patients presenting with blunt thoracic trauma. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: As the use of point-of-care TEE during resuscitation continues to expand in emergency medicine, the evaluation of patients with BTAI represents a novel application where this emerging modality can allow early diagnosis of these injuries in hemodynamically unstable patients.

Matched MeSH terms: Aorta/injuries

Numerical simulations of flow through the aorta using both ideal and realistic geometrical models

Wan Ab Naim WN, Ganesan P, Al Abed A, Lim E

Annu Int Conf IEEE Eng Med Biol Soc, 2012;2012:653-6.

PMID: 23365977 DOI: 10.1109/EMBC.2012.6346016

The effects of curvature and tapering on the flow progression in the aorta were studied using numerical simulations on a realistic geometrical model of the aorta and three different versions of the ideal aorta models. The results showed that tapering increases velocity magnitude and wall shear stress while local curvatures affect the skewness of the velocity profile, the thickness of the boundary layer as well as the recirculation regions. Wall shear stress distribution in the aorta serves as an important determinant in the progression of arterial disease.

Matched MeSH terms: Aorta/anatomy & histology*; Aorta/physiology*; Aorta, Thoracic/anatomy & histology; Aorta, Thoracic/physiology

Vasorelaxant effect of 5,7,4'- Trihydroxyflavanone (Naringenin) via endothelium dependent, potassium and calcium channels in Sprague Dawley rats: Aortic ring model

Tan CS, Tew WY, Jingying C, Yam MF

Chem Biol Interact, 2021 Oct 01;348:109620.

PMID: 34411564 DOI: 10.1016/j.cbi.2021.109620

Naringenin is a naturally occurring flavanone (flavonoid) known to have bioactive effects on human health. It has been reported to show cardiovascular effects. This study aimed to investigate the possible vasorelaxant effect of naringenin and the mechanism behind it by using a Sprague Dawley rat aortic ring assay model. Naringenin caused significant vasorelaxation of endothelium-intact aortic rings precontracted with phenylephrine (pD2 = 4.27 ± 0.05; Rmax = 121.70 ± 4.04%) or potassium chloride (pD2 = 4.00 ± 0.04; Rmax = 103.40 ± 3.82%). The vasorelaxant effect decreased in the absence of an endothelium (pD2 = 3.34 ± 0.10; Rmax = 62.29 ± 2.73%). The mechanisms of the vasorelaxant effect of naringenin in the presence of antagonists were also investigated. Indomethacin, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, atropine, 4-aminopyridine, Nω-nitro-l-arginine methyl ester, glibenclamide and propranolol significantly reduced the relaxation stimulated by naringenin in the presence of endothelium. Besides that, the effect of naringenin on the voltage-operated calcium channel (VOCC) in the endothelium-intact aortic ring was studied, as was intracellular Ca2+ release from the sarcoplasmic reticulum (SR) in the endothelium-denuded aortic ring. The results showed that naringenin also significantly blocked the entry of Ca2+ via the VOCC, SERCA/SOCC and suppressed the release of Ca2+ from the SR. Thus, the vasorelaxant effect shown by naringenin mostly involve the COX pathway, the endothelium-dependent pathway via NO/sGC/prostaglandin, calcium and potassium channels.

Matched MeSH terms: Aorta/drug effects; Aorta/metabolism

Fulltext Thoracic Endovascular Aortic Repair (TEVAR) in traumatic high-velocity blunt injury to thoracic aorta

Nor Elina NS, Naresh G, Hanif H, Zainal AA

Med J Malaysia, 2013 Jun;68(3):239-44.

PMID: 23749014 MyJurnal

Matched MeSH terms: Aorta, Thoracic*

Acute aortic dissection at two extreme ages

Ramzisham AR, Arief H, Ngoo KS, Zamrin DM, Joanna OS

Clin Ter, 2011;162(6):553-4.

PMID: 22262328

Acute aortic dissection is a life-threatening condition, warranting prompt diagnosis and treatment. Management of which incorporates multidisciplinary expertise from the medical, surgical and intensive care. If left untreated, the mortality rate of acute aortic disease exceeds 50% within 48 hours and 80% within two weeks, with a 5-year survival rate of 19%. The most common cause of death in untreated acute aortic dissection, regardless of aetiology, is aortic rupture. We would like to share our successful experience of cases at the two extreme ages of acute aortic dissection. Literature review with their pathogenesis are discussed.

Matched MeSH terms: Aorta, Thoracic*

Fulltext Idiopathic cystic medionecrosis and aneurysms of the ascending aorta

Anuar M, Singham KT

Med J Malaysia, 1983 Mar;38(1):35-8.

PMID: 6633332

Two patients with ascending aortic aneurysms due to cystic medical necrosis are described. One of them was phenotypically normal while the other had features of Marfan's syndrome. Both were disabled by dyspnoea and angina which required corrective surgery.

Matched MeSH terms: Aorta/pathology*

Salmonella enteritidis abdominal aorta mycotic aneurysm presented with acute cholestatic jaundice: A case report and literature review

Wahab AA, Mohamed N, Ding CH, Muttaqillah NAS, Rosli N, Mohammed F

Trop Biomed, 2023 Mar 01;40(1):23-28.

PMID: 37356000 DOI: 10.47665/tb.40.1.008

Mycotic aneurysm is one of the extra-intestinal manifestations of Salmonella Enteritidis infection. The diagnosis of this condition is challenging owed to its variation in clinical presentations. We presented a case of a 54-year-old man with underlying diabetes mellitus and chronic smokers presented with acute right flank pain and fever associated with mild jaundice. The initial laboratory investigations suggested features of obstructive jaundice and urinary tract infection. The contrast enhancing computed tomography of the abdomen revealed the presence of saccular mycotic aneurysm located at the infrarenal abdominal aorta. The blood culture grew Salmonella Enteritidis which was susceptible to ceftriaxone, trimethoprim-sulfamethoxazole, ciprofloxacin, ampicillin, and amoxicillin-clavulanic acid. Intravenous ceftriaxone was initiated, and he underwent open surgery and artery repair at day 8 of admission. He responded well to the treatment given and subsequently discharged home after completed three weeks of intravenous ceftriaxone.

Matched MeSH terms: Aorta, Abdominal/surgery

Single stage treatment of complex aortic pathology (mega-aortic syndrome) using frozen elephant trunk technique

Krishna Moorthy PS, Saat SA, Sakijan AS

Med J Malaysia, 2019 02;74(1):94-96.

PMID: 30846673

This is a case report of single-stage total thoracic aortic repair by the frozen elephant trunk technique for a 75-yearold female with a complex aortic pathology of mega-aorta extending from the ascending aorta to the descending aorta. We used a Thora flex™ Hybrid device, a frozen elephant trunk device with four branched grafts and the distal stent graft. The distal stent graft was inserted into the downstream descending aorta via an aortic arch and positioned 15 cm beyond the left subclavian artery after total arch replacement had been performed using a four-branch graft. The postoperative course was unremarkable with no complications. A post procedural computed tomography scan demonstrated complete exclusion of the descending thoracic aneurysm without endoleak. Therefore, fixing the whole mega-aorta in a single stage using the frozen elephant trunk was effective and safe.

Matched MeSH terms: Aorta/surgery; Aorta, Thoracic/surgery*

Fulltext Pressure reduction on blood flow in aorta coronary sinus conduit

Siti Aslina Hussain, Tan, Hong Tat, Mohd Ismail Abdul Hamid, Norhafizah Abdullah, Azni Idris

Pertanika Journal of Science & Technology, 2012;20(2):347-353.

MyJurnal

Numerical studies of blood flow system of aorta coronary sinus conduit were carried out using ANSYSTMCFD simulation. A different model of conduit, which differs in the inlet diameter, was investigated. Theinvestigated inlet diameters are 3 mm, 4 mm and 5 mm. Pressure drop from 80 mmHg to 15 mmHgwas achieved for all the models. The comparison chart was produced to compare the pattern of pressurereduction as well as velocity distribution in each model. From the analysis of coronary sinus conduit,it was found that a narrow tube needs to be incorporated into the conduit produced. This is to inducea venturi effect to reduce the pressure drop of blood within a specific throat length. As conclusion, amodel of 3 mm inlet and a throat diameter of 1.13 mm show satisfactory result for pressure reductionfrom 80 mmHg to 15 mmHg. This particular model also has a lower peak velocity at the inlet zone ofthe throat section, which is more preferable in terms of Reynolds number.

Matched MeSH terms: Aorta

Fulltext Dysphagia Lusoria From Saccular Aneurysm :A Cause Of: A Case Report

Irfan, M., Khairi, M.D., Baharudin, A.

International Medical Journal Malaysia, 2007;6(1):1-5.

MyJurnal

Dysphagia is a common symptom in patients presenting to the otorhinolaryngolgy clinic. However, vascular causes (dysphasia lusoria) are relatively rare. W report a case of dysphagia caused by a saccular aneurysm of the descending thoraric aorta. The outline of management is discussed.

Matched MeSH terms: Aorta, Thoracic

Fulltext Emphysematous aortitis: report of two cases and CT imaging findings

Md Noh MSF, Abdul Rashid AM, Ar A, B N, Mohammed Y, A R E

BJR Case Rep, 2017;3(3):20170006.

PMID: 30363220 DOI: 10.1259/bjrcr.20170006

Emphysematous aortitis is a rare condition that manifests through the presence of air within or surrounding the inflamed aorta. Aortic inflammation may result from either an infective or a non-infective cause. Recognition of this rare condition is important as the resultant clinical deterioration may be rapid and lead to inevitable death. Cross-sectional imaging, with its relatively wide availability, proves an important tool in the diagnosis and subsequent management of this condition. We report two such cases encountered in our centre, with particular focus on the imaging findings on CT.

Matched MeSH terms: Aorta

Modification of Aortic Cannula With an Inlet Chamber to Induce Spiral Flow and Improve Outlet Flow

Darlis N, Osman K, Padzillah MH, Dillon J, Md Khudzari AZ

Artif Organs, 2018 May;42(5):493-499.

PMID: 29280161 DOI: 10.1111/aor.13021

Physiologically, blood ejected from the left ventricle in systole exhibited spiral flow characteristics. This spiral flow has been proven to have several advantages such as lateral reduction of directed forces and thrombus formation, while it also appears to be clinically beneficial in suppressing neurological complications. In order to deliver spiral flow characteristics during cardiopulmonary bypass operation, several modifications have been made on an aortic cannula either at the internal or at the outflow tip; these modifications have proven to yield better hemodynamic performances compared to standard cannula. However, there is no modification done at the inlet part of the aortic cannula for inducing spiral flow so far. This study was carried out by attaching a spiral inducer at the inlet of an aortic cannula. Then, the hemodynamic performances of the new cannula were compared with the standard straight tip end-hole cannula. This is achieved by modeling the cannula and attaching the cannula at a patient-specific aorta model. Numerical approach was utilized to evaluate the hemodynamic performance, and a water jet impact experiment was used to demonstrate the jet force generated by the cannula. The new spiral flow aortic cannula has shown some improvements by reducing approximately 21% of impinging velocity near to the aortic wall, and more than 58% reduction on total force generated as compared to standard cannula.

Matched MeSH terms: Aorta/anatomy & histology; Aorta/physiology; Aorta/surgery*

Fulltext Ultrasonographic assessment of inferior vena cava/abdominal aorta diameter index: a new approach of assessing hypovolemic shock class 1

Rahman NH, Ahmad R, Kareem MM, Mohammed MI

Int J Emerg Med, 2016 Dec;9(1):8.

PMID: 26894896 DOI: 10.1186/s12245-016-0101-z

We designed this study to expand the usage of ultrasound to detect early occurrence of hypovolemia. We explore the potential use of inferior vena cava (IVC) and abdominal aorta (AA) diameter index (IVC:AA) measured ultrasonographically to detect class 1 hypovolemic shock with blood loss less than 15%.ᅟ

Matched MeSH terms: Aorta, Abdominal

Fulltext Combined repair of aortic arch aneurysm and coronary artery bypass grafting via a modified clamshell incision

Eng JB

Med J Malaysia, 2007 Jun;62(2):177-8.

PMID: 18705461 MyJurnal

A 58 year-old man presented with a large aneurysm of the aortic arch and severe coronary artery disease. He underwent combined repair of the aortic arch aneurysm and coronary artery bypass grafting via a modified clamshell incision using deep hypothermic circulatory arrest and retrograde cerebral perfusion. He made an uncomplicated postoperative recovery. The operative techniques are discussed with a review of the relevant literature.

Matched MeSH terms: Aorta, Thoracic/surgery*

Fulltext The cervical aortic arch

Hoe TS, Chan KC, Zambahari R

Med J Malaysia, 1987 Jun;42(2):90-2.

PMID: 3503196

A patient with a cervical aortic arch associated with a coarctation of the aortic arch and a Tetralogy of Fallot presented to the General Hospital, Kuala Lumpur.

Matched MeSH terms: Aorta, Thoracic/abnormalities*

Fulltext Anomalous right pulmonary artery from aorta, surgical approach case report and literature review

Alhawri K, Alakhfash A, Alqwaee A, HassabElnabi M, Ahmed F, Alhawri M, et al.

J Card Surg, 2021 Aug;36(8):2890-2900.

PMID: 34047395 DOI: 10.1111/jocs.15618

BACKGROUND: Anomalous origin of one pulmonary artery from the aorta is a rare congenital anomaly affecting the right pulmonary artery more than the left. These patients are at risk for the early development of significant pulmonary hypertension. Early surgical treatment has been proven safe with excellent results. The surgical approach and technique is challenging and should be decided ahead before the patient to surgery. Different techniques were described including direct reimplantation, conduit interposition, aortic ring flap.

AIM: We present a neonate with anomalous origin of the right pulmonary artery from the aorta and discuss the surgical technique and complications in the literature.

Matched MeSH terms: Aorta/surgery

Fulltext Fluorescence multispectral imaging-based diagnostic system for atherosclerosis

Ho CS, Horiuchi T, Taniguchi H, Umetsu A, Hagisawa K, Iwaya K, et al.

Biomed Eng Online, 2016 Aug 20;15(1):98.

PMID: 27542354 DOI: 10.1186/s12938-016-0220-z

Composition of atherosclerotic arterial walls is rich in lipids such as cholesterol, unlike normal arterial walls. In this study, we aimed to utilize this difference to diagnose atherosclerosis via multispectral fluorescence imaging, which allows for identification of fluorescence originating from the substance in the arterial wall.

Matched MeSH terms: Aorta, Abdominal/pathology

Displaying publications 1 - 20 of 218 in total