MyMedR

Fulltext Re: Controversies in Odontogenic Tumours: Review

Gopinath D, Menon RK

Sultan Qaboos Univ Med J, 2018 05;18(2):e249-e250.

PMID: 30210864 DOI: 10.18295/squmj.2018.18.02.026

Matched MeSH terms: Ameloblastoma*

Fulltext The complexity of stromal changes in desmoplastic ameloblastoma

Ramesh V, Singh S, Bailwad S, Kiran K, Agarwal R, Singh A

Ann Med Health Sci Res, 2014 Mar;4(Suppl 1):S14-7.

PMID: 25031898 DOI: 10.4103/2141-9248.131694

Ameloblastoma is usually considered a homogenous neoplasm and is thought of as the most primitive of all odontogenic neoplasms. However, detailed investigations have proven clinicopathological diversity in a significant number of cases, thus mounting the evidence in favor of considering ameloblastoma as a mysterious lesion. The purpose of this article is to report a unique case of desmoplastic ameloblastoma and to throw light on the atypical changes noticed in the stromal component. The findings of this case have served to add interesting parameters to the study of stromal changes associated with this perplexing odontogenic tumor.

Matched MeSH terms: Ameloblastoma

Intra-epithelially entrapped blood vessels in ameloblastoma

Siar CH, Ishak I, Ng KH

J Oral Pathol Med, 2015 May;44(5):378-85.

PMID: 25155411 DOI: 10.1111/jop.12247

The ameloblastoma is a benign but locally aggressive odontogenic neoplasm with a high recurrence rate. While significant progress has been made in our understanding regarding the role of tumoral vasculature relative to the diverse behavioral characteristics of this tumor, no attention has been paid to a distinct subset of blood vessels entrapped within its epithelial compartment. As vascular niches are known to influence tumoral growth, clarification of these vessels is important. The objectives of this study were to investigate the morphologic characteristics of intra-epithelially entrapped blood vessels (IEBVs) in ameloblastoma and to speculate on their relevance.

Matched MeSH terms: Ameloblastoma

Ameloblastomas in children. Report of a case and review of the literature

Ramanathan K, Guan LS

Dent J Malaysia Singapore, 1968 Feb;8(1):36-42.

PMID: 4235968

Matched MeSH terms: Ameloblastoma

Granular ameloblastoma: report of two cases with atypical cytological aspects

Arora S, Urs AB, Kumar P, Augustine J, Saran RK

Rom J Morphol Embryol, 2017;58(3):997-1001.

PMID: 29250680

Ameloblastoma is an aggressive odontogenic tumor, which arises from odontogenic epithelium. Ameloblastomas can present in several clinical and histomorphological patterns. The granular cell variant accounts for only 3.5% to 5% of ameloblastomas. We have presented two cases of granular cell ameloblastoma (GCA) occurring in a 44-year-old and 50-year-old man, respectively. Case No. 1 on incisional biopsy was diagnosed as unicystic ameloblastoma (UA), which later after excisional biopsy was finally diagnosed as GCA owing to the features observed in excisional biopsied tissue. Case No. 2 on incisional biopsy showed darker and lighter stained cells arranged in small follicular pattern, and anastomosing cords. Meticulous immunohistochemistry, histochemical examination and careful literature search helped us to diagnose it as GCA. We have made an attempt to elucidate the diagnosis of GCA especially in cases of GCA with unusual granular component.

Matched MeSH terms: Ameloblastoma/diagnosis*; Ameloblastoma/pathology; Ameloblastoma/therapy

Fulltext Ameloblastoma: a still controversial tumour

Zain R, Janakarajah N

Med J Malaysia, 1985 Jun;40(2):115-9.

PMID: 3834281

This is a review of 20 cases of ameloblastomas diagnosed and treated at the Dental Faculty, University of Malaya, Kuala Lumpur. The clinical features, histological features and treatment methods are presented. Two basic clinical types namely the conventional (solid/multicystic) and unicystic ameloblastomas showed different recurrence rates. Discrepancies between the recurrent rates in this study for conventional ameloblastoma and for unicystic ameloblastoma and those of other reports are discussed. A brief discussion on the treatment modalities used is also presented.

Matched MeSH terms: Ameloblastoma/surgery*

Some observations on cysts, adamantinomata and osteomyelitis of the jaws among the population in Malaya

KARIM A

Br Dent J, 1949 Sep 2;87(5):118-20.

PMID: 18146827

Matched MeSH terms: Ameloblastoma*

Fulltext Conservative surgical management of ameloblastoma of the mandible--report on three cases

Foo GC, Siar CH, Ling KC, Chin CT

Med J Malaysia, 1983 Dec;38(4):334-8.

PMID: 6599995

Features of the typical ameloblastoma of the mandible are outlined. Three cases managed by conservative surgical treatment maintaining the continuity of the mandible are described. The factors taken into consideration when instituting this method of treatment are discussed. Results obtained are encouraging.

Matched MeSH terms: Ameloblastoma/radiography; Ameloblastoma/surgery*

Combined granular cell ameloblastoma and plexiform granular cell odontogenic tumour

Siar CH, Ng KH, Chia TY

Singapore Dent J, 1990 Dec;15(1):35-7.

PMID: 2097728

Granular cell ameloblastomas are uncommon lesions accounting for about 3-5% of all histologic subtypes of ameloblastoma. The plexiform granular cell odontogenic tumour, on the other hand, is a newly described lesion characterised by a monophasic plexiform pattern of granular cells. This article reports a tumour found occurring in the left mandible of a 67-year-old Indian male which histologically showed features of both the aforementioned lesions.

Matched MeSH terms: Ameloblastoma/complications; Ameloblastoma/pathology*

Calcifying and keratinizing ameloblastoma of the maxilla

Siar CH, Ng KH

J Laryngol Otol, 1991 Nov;105(11):971-2.

PMID: 1722237

A case is described of ameloblastoma of maxilla presenting with numerous calcified keratin pearls. The significance of cellular variation in relation to the behavioural potential of the ameloblastoma in general is briefly discussed.

Matched MeSH terms: Ameloblastoma/pathology*

Atypical peripheral ameloblastoma of the palate

Siar CH, Ng KH, Ngui CH, Chuah CH

J Laryngol Otol, 1990 Mar;104(3):252-4.

PMID: 2341785

Clinical, radiological and histological characteristics of the peripheral ameloblastoma are briefly outlined. A case found occurring in the palate and presenting with atypical histological features is reported. The differential diagnosis of this lesion, its treatment and histogenesis are discussed.

Matched MeSH terms: Ameloblastoma/pathology*

Unicystic Ameloblastoma: A Perception for the Cautious Interpretation of Radiographic and Histological Findings

Arora S

J Coll Physicians Surg Pak, 2015 Oct;25(10):761764-764.

PMID: 26454399 DOI: 10.2015/JCPSP.761764

The term Unicystic Ameloblastoma (UA) refers to those cystic lesions that show clinical and radiological characteristics of an odontogenic cyst but on histological examination show a typical ameloblastomatous epithelium lining part of the cyst cavity, with or without luminal and/or mural tumor growth. Till date, lot of controversies exist among oral surgeons and oral pathologists regarding this entity. An attempt is being made here to discuss all the diagnostic dilemmas associated with UA.

Matched MeSH terms: Ameloblastoma/diagnosis*; Ameloblastoma/pathology; Ameloblastoma/radiography

Unicystic ameloblastoma: a late recurrence with pseudo-glandular features. A case report

Khoo SP, High AS, Awang MN

Singapore Dent J, 1995 Jul;20(1):21-3.

PMID: 9582685

A case of unicystic ameloblastoma which recurred after 15 years showing unusual histological features is reported. The prominent pseudo-glandular features present are described. This case highlights the importance of extensive histological examination for more characteristic features of ameloblastoma to reach a correct diagnosis.

Matched MeSH terms: Ameloblastoma/pathology*; Ameloblastoma/radiography; Ameloblastoma/surgery

Fulltext Desmoplastic Ameloblastoma of the Mandible: A Case Report

Rajan Saini, Abdul Rani Samsudin

International Medical Journal Malaysia, 2008;7(1):1-7.

MyJurnal

Desmoplastic ameloblastoma (DA) is a relatively rare histological variant of ameloblastoma. DA do not present with radiographic or clinical features that are typical of other variants of ameloblastoma. On gross examination, DA appears as a solid mass, unlike the conventional ameloblastoma that contains fluid-filled spaces. Although radiographic examination of ameloblastomas usually reveals unilocular or multilocular radiolucency, DA may appear as a mixed radiopaque-radiolucent lesion. Histologically, DA is characterized by small nests and strands of “compressed” odontogenic epithelium supported by pronounced collagenized stroma. This report describes the case of a 30-year-old male with DA of the left mandible.

Matched MeSH terms: Ameloblastoma

Mandibular hemangio-ameloblastoma

Arora S, Kanneppady SK, Banavar SR, Jnanendrappa N

QJM, 2019 Aug 01;112(8):615-616.

PMID: 31120127 DOI: 10.1093/qjmed/hcz117

Matched MeSH terms: Ameloblastoma/diagnosis*; Ameloblastoma/pathology; Ameloblastoma/surgery

An unsuspected ameloblastoma in the subpontic region of the mandible with consideration of pathogenesis from the radiographic course

Siar CH, Nakano K, Chelvanayagam PI, Ng KH, Nagatsuka H, Kawakami T

Eur J Med Res, 2010 Mar 30;15(3):135-8.

PMID: 20452900

The purpose of this report is to document a case of unsuspected ameloblastoma involving the right man dibular subpontic region in a 38-year-old Cambodian female patient. This lesion was purportedly preceded by multiple radiolucencies which were diagnosed as radicular cysts and treated a few times in the past years by enucleation followed by endodontic therapy of the affected teeth. Bridgework restoration of the partially edentulous area was performed. This case report demonstrates radiographic changes that occurred in the periods before and after the diagnosis of ameloblastoma. The case may represent an example of radicular cysts and ameloblastoma occurring as a collision phenomenon, or the ameloblastoma may have arisen as a result of neoplastic transformation of the lining epithelium in an inflammatory odontogenic epithelial cyst.

Matched MeSH terms: Ameloblastoma/etiology; Ameloblastoma/pathology*; Ameloblastoma/surgery

Fulltext Traumatic neuroma in wall of recurrent unicystic ameloblastoma: a case report

Zain R, Ling KC

Med J Malaysia, 1985 Mar;40(1):49-51.

PMID: 3831736

This is a case report of a recurrent lesion diagnosed histologically as a unicystic ameloblastoma. The concomitant presence of a traumatic neuroma was observed within the wall of the recurrent lesion. The mode of development of the traumatic neuroma, and the reason for the recurrence were presented.

Matched MeSH terms: Ameloblastoma/pathology*

Fulltext Acanthomatous ameloblastoma in anterior mandibular region of a young patient: A rare case report

Ugrappa S, Jain A, Fuloria NK, Fuloria S

Ann Afr Med, 2017 Apr-Jun;16(2):85-89.

PMID: 28469123 DOI: 10.4103/aam.aam_51_16

Ameloblastoma is the most known of the epithelial odontogenic benign tumor. It is slow growing and locally aggressive in nature and most commonly seen in the posterior mandible. Various histopathological variants exist, among which acanthomatous type of ameloblastoma is one of the rarest types. Acanthomatous ameloblastoma is usually seen in older aged human population and most commonly reported in canine region of dogs in literature. Here, we report a rare case of acanthomatous ameloblastoma in a young male patient involving mandibular anterior region crossing the midline with recurrence over a period of 2 years of follow-up after surgical resection.

Matched MeSH terms: Ameloblastoma/surgery*

Fulltext The radiographic appearance of ameloblastoma in Malaysians

Yaacob H

Singapore Med J, 1991 Feb;32(1):70-2.

PMID: 2017711

The radiographs of fifteen Malaysian patients with presenting ameloblastoma aged between 20-55 years (average 35 years) were studied for any peculiar local features. The most common features were cortical plate expansion (80%), corticated scalloped margin (67%), multiloculation (87%), and resorption of tooth roots (47%). The latter two features are constantly found in advanced tumour stage. As pain was not a frequent complaint, many Malaysian patients seek treatment only at a very late stage after the tumours have reached large dimensions. Although ameloblastomas may be diagnosed often through radiographs, it should not be relied upon solely.

Matched MeSH terms: Ameloblastoma/radiography*

Fulltext Homeobox Genes in Odontogenic Lesions: A Scoping Review

Hii EPW, Ramanathan A, Pandarathodiyil AK, Wong GR, Sekhar EVS, Binti Talib R, et al.

Head Neck Pathol, 2023 Mar;17(1):218-232.

PMID: 36344906 DOI: 10.1007/s12105-022-01481-2

BACKGROUND: Homeobox genes play crucial roles in tooth morphogenesis and development and thus mutations in homeobox genes cause developmental disorders such as odontogenic lesions. The aim of this scoping review is to identify and compile available data from the literatures on the topic of homeobox gene expression in odontogenic lesions.

METHOD: An electronic search to collate all the information on studies on homeobox gene expression in odontogenic lesions was carried out in four databases (PubMed, EBSCO host, Web of Science and Cochrane Library) with selected keywords. All papers which reported expression of homeobox genes in odontogenic lesions were considered.

RESULTS: A total of eleven (11) papers describing expression of homeobox genes in odontogenic lesions were identified. Methods of studies included next generation sequencing, microarray analysis, RT-PCR, Western blotting, in situ hybridization, and immunohistochemistry. The homeobox reported in odontogenic lesions includes LHX8 and DLX3 in odontoma; PITX2, MSX1, MSX2, DLX, DLX2, DLX3, DLX4, DLX5, DLX6, ISL1, OCT4 and HOX C in ameloblastoma; OCT4 in adenomatoid odontogenic tumour; PITX2 and MSX2 in primordial odontogenic tumour; PAX9 and BARX1 in odontogenic keratocyst; PITX2, ZEB1 and MEIS2 in ameloblastic carcinoma while there is absence of DLX2, DLX3 and MSX2 in clear cell odontogenic carcinoma.

CONCLUSIONS: This paper summarized and reviews the possible link between homeobox gene expression in odontogenic lesions. Based on the current available data, there are insufficient evidence to support any definite role of homeobox gene in odontogenic lesions.

Matched MeSH terms: Ameloblastoma*

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