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  1. Predictive markers of early endothelial dysregulation in type-1 diabetes: a meta-analysis
    Ranasinghe R, Mathai M, Alshawsh MA, Zulli A, Ranasinghe R
    Acta Diabetol, 2024 Nov 11.
    PMID: 39527296 DOI: 10.1007/s00592-024-02401-2
    BACKGROUND: This study identifies a new set of salient risk factors that may trigger danger signals of vascular dysregulation in T1D. Vascular abnormalities and impairment of CVD is a major adverse effect of T1D, particularly affecting children, adolescents and young adults.

    METHODS: The patients of T1D were compared with the healthy control (HC) for the risk factors of vascular dysregulation in published studies from year 2013 to 2023. The PubMed, Web of Science and Google Scholar databases were searched from 1/1/2013 to 1/9/2023. The risk of bias was assessed with the Cochrane (ROBINS-I ) tool, relevant to clinical subjects. A random effects model was followed and analysed by RevMan 5.4 and GraphPad Prism software.

    RESULTS: 80 relevant case-control studies having 7492 T1D patients and 5293 HC were included. The age and sex-matched HC consisted of persons free of disease and not under any medication while clinical subjects of

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