Thromboembolic complications are common amongst cases of COVID-19 infections. This occurrence has seen a key role of endovascular treatment in the management of this potentially fatal complication. Endovascular thrombectomy or catheter directed thrombolysis is a fast and effective method for treatment of pulmonary embolisms, especially in a pandemic. We describe a case of COVD-19 complicated with massive pulmonary embolism treated with catheter directed thrombolysis- discussing case management, patient workflow and safety measures that should be strictly adhered to ensure a favorable outcome and ensure safety of treating personnel.