In this study, the effects of palm vitamin E (PV) supplementation on glycemic control and lipid profile in diabetic-induce Sprague-Dawley rats have been evaluated. Diabetes in the rats was induced by a single intravenous streptozotocin (50 mg/kg body weight). The diabetic rats were divided into two groups; supplemented with 200 mg/kg body weight/day of PV and non-supplemented with PV (No PV group). Non-diabetic rats (NDM) formed the control group and only received saline injection. After eight weeks of daily supplementation, PV significantly lowered the fasting blood glucose (FBG) and glycosylated haemoglobin (HbA1c) levels (p