MyMedR

Displaying all 3 publications

Abstract:

Sort:

Nexus amongst environmental regulations, carbon emission intensity and technological innovation in China's construction industry

Wang L, Long X, Wu KJ, Tseng ML, Cao Y

Environ Sci Pollut Res Int, 2023 Mar 27.
PMID: 36967430 DOI: 10.1007/s11356-023-26554-9

China's construction industry confronts with the dilemma of carbon emissions in adjusting the environmental regulations. Many studies are neglected on discovering the potential nexus amongst environmental regulations (ERs), technological innovation (TI) and CEI (CEI) and ignores the relationships amongst TI for reducing CEI. To mitigate this gap, this study bridges institutional theory to integrate the practices in the construction industry. This study applies a panel dataset on the construction industry from 30 provinces during 2004-2018 and uses it with a two-step system-generalised method of moments for analysis. The proposed method enables the prevention of the interference of the heteroscedasticity problem and improves certain analytical efficiency. The results are as a guideline for policymakers in rechecking the policies and regulations adequacy. The findings indicate that (1) the forced emission reduction effect is proven by command-and-control and market-based ERs, which can inhibit CEI; (2) voluntary ERs have an inverted U-shaped nexus with CEI; in other words, the green paradox effect shifts to the forced emission reduction effect once the intensity of voluntary ERs increases; and (3) market-based and voluntary ERs reduce CEI effectively by using TI as the mediator in construction industry.
Fulltext Organ defects of the Usp7K444R mutant mouse strain indicate the essential role of K63-polyubiquitinated Usp7 in organ formation

Wu HT, Lin YT, Chew SH, Wu KJ

Biomed J, 2023 Feb;46(1):122-133.
PMID: 35183794 DOI: 10.1016/j.bj.2022.02.002

BACKGROUND: K63-linked polyubiquitination of proteins have nonproteolytic functions and regulate the activity of many signal transduction pathways. USP7, a HIF1α deubiquitinase, undergoes K63-linked polyubiquitination under hypoxia. K63-polyubiquitinated USP7 serves as a scaffold to anchor HIF1α, CREBBP, the mediator complex, and the super elongation complex to enhance HIF1α-induced gene transcription. However, the physiological role of K63-polyubiquitinated USP7 remains unknown.
METHODS: Using a Usp7K444R point mutation knock-in mouse strain, we performed immunohistochemistry and standard molecular biological methods to examine the organ defects of liver and kidney in this knock-in mouse strain. Mechanistic studies were performed by using deubiquitination, immunoprecipitation, and quantitative immunoprecipitations (qChIP) assays.
RESULTS: We observed multiple organ defects, including decreased liver and muscle weight, decreased tibia/fibula length, liver glycogen storage defect, and polycystic kidneys. The underlying mechanisms include the regulation of protein stability and/or modulation of transcriptional activation of several key factors, leading to decreased protein levels of Prr5l, Hnf4α, Cebpα, and Hnf1β. Repression of these crucial factors leads to the organ defects described above.
CONCLUSIONS: K63-polyubiquitinated Usp7 plays an essential role in the development of multiple organs and illustrates the importance of the process of K63-linked polyubiquitination in regulating critical protein functions.
Fulltext Future trends and guidance for the triple bottom line and sustainability: a data driven bibliometric analysis

Tseng ML, Chang CH, Lin CR, Wu KJ, Chen Q, Xia L, et al.

Environ Sci Pollut Res Int, 2020 Sep;27(27):33543-33567.
PMID: 32572746 DOI: 10.1007/s11356-020-09284-0

This study conducts a comprehensive literature review of articles on the triple bottom line (TBL) published from January 1997 to September 2018 to provide significant insights and support to guide further discussion. There were three booms in TBL publications, occurring in 2003, 2011, and 2015, and many articles attempt to address the issue of sustainability by employing the TBL. This literature analysis includes 720, 132, and 58 articles from the Web of Science (WOS), Inspec, and Scopus databases, respectively, and reveals the gaps in existing research. To discover the barriers and points of overlap, these articles are categorized into six aspects of the TBL: economic, environmental, social, operations, technology, and engineering. Examining the top 3 journals in terms of published articles on each aspect reveals the research trends and gaps. The findings provide solid evidence confirming the argument that the TBL as currently defined is insufficient to cover the entire concept of sustainability. The social and engineering aspects still require more discussion to support the linkage of the TBL and to reinforce its theoretical basis. Additionally, to discover the gaps in the data sources, theories applied, methods adopted, and types of contributions, this article summarizes 82 highly cited articles covering each aspect. This article offers theoretical insights by identifying the top contributing countries, institutions, authors, keyword networks, and authorship networks to encourage scholars to push the current discussion further forward, and it provides practical insights to bridge the gap between theory and practice for enhancing the efficiency and effectiveness of improvements.

Filters

Please provide feedback to Administrator ([email protected])

External Links