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Knowledge mapping of spastic cerebral palsy. A bibliometric analysis of global research (2000-2022)

Wang X, Teh SH, Wang XH

Ital J Pediatr, 2024 Jan 18;50(1):9.
PMID: 38238820 DOI: 10.1186/s13052-024-01577-1

BACKGROUND: Cerebral palsy (CP) is characterized by abnormal pronunciation, posture, and movement. Spastic CP accounts for more than 70% of all CP. To date, there has been no bibliometric analysis to summarize study on spastic CP. Here, we aim to conduct a bibliometric analysis of spastic CP to summarize this field's knowledge structure, research hotspots, and frontiers.
METHOD: Publications about spastic CP were searched utilizing the Web of Science Core Collection (WoSCC) database from 1 January 2000 to 30 November 2022, the WoSCC literature analysis wire, VOSviewer 1.6.18, CiteSpace 6.1.R4 and Online analysis platform for bibliometrics were used to conduct the analysis.
RESULTS: A total of 3988 publications, consisting of 3699 articles and 289 reviews, were included in our study. The United States emerged as the most productive country, while Kathleen Univ Leuven was the most productive institution. The leading author was Desloovere K. A total of 238 journals contributed to this field, with Developmental medicine and child neurology being the leading journal. Important keywords and keyword clusters included Spastic cerebral palsy, Reliability, and Gross motor function. Keywords identified through burst detection indicated that hotspots in this field were management, randomized controlled trials, and definition.
CONCLUSION: Based on the analysis of bibliometric on spastic CP over the past 20 years, the trends and the knowledge graph of the countries, institutions, authors, references, and the keywords have been identified, providing accurate and expedited insights into critical information and potentially new directions in the study of spastic CP.
Fulltext Acupuncture and Tuina Treatment for Gross Motor Function in Children with Spastic Cerebral Palsy: A Monocentric Clinical Study

Wang X, Teh SH, Du XG, Wang XH

Neuropsychiatr Dis Treat, 2023;19:1875-1886.
PMID: 37667737 DOI: 10.2147/NDT.S424102

OBJECTIVE: Cerebral palsy (CP) is a condition characterized by abnormal pronunciation, posture, and movement, particularly spastic CP, which involves Gross motor dysfunction due to increased muscle tone and stiffness. This monocentric clinical study aims to evaluate the effectiveness of acupuncture and tuina (AT) in improving gross motor function and alleviating associated symptoms in children diagnosed with spastic CP.
METHODS: A total of 83 eligible patients received AT treatment, while 85 patients received conventional rehabilitation treatment. Both groups underwent a 12-week treatment period following the research protocol. Pre- and post-treatment assessments included the Modified Ashworth Muscle Tension Scale (MAS), Gross Motor Function Measure (GMFM-D and GMFM-E), 6-min walking distance measurement (6MWD), and Modified Children's Functional Independence Rating Scale (WeeFIM).
RESULTS: After 12 weeks of treatment, when compared with baseline, the scores of MAS in both AT group and control group are decreased (p<0.01, p<0.01), the scores of GMFM-D, GMFME, 6MWD, WeeFIM in both group are increased (p<0.01 in all indicators). When compared with control group, AT group had significantly lower MAS scores compared to the control group (p<0.01), indicating reduced muscle tension. Moreover, AT group showed significantly higher scores in GMFM-D, GMFM-E, 6MWD, and WeeFIM compared to the control group (p<0.01 in all indicators), indicating improved gross motor function and functional independence. The study also revealed an inverse correlation between the children's age and treatment efficacy (r= -0.496, p<0.01 in AT group, r=-0.540, p<0.01 in control group), highlighting the importance of early intervention in the management of CP in children.
CONCLUSION: These findings suggest that AT may effectively enhance gross motor function and alleviate associated symptoms in children diagnosed with spastic CP. Moreover, early initiation of treatment is crucial to maximize therapeutic efficacy in children with spastic CP.
TRIAL REGISTRATION: Chinese Clinical Trial Registry, ChiCTR2200059823. Registered on 12 May 2022.
[Over one hundred year sedimentary record of polycyclic aromatic hydrocarbons in the Andaman Sea, Malaysia]

Wu YL, Wang XH, Li YY, Hong HS, Li HY, Yin MD

Huan Jing Ke Xue, 2009 Sep 15;30(9):2512-9.
PMID: 19927796

Polycyclic aromatic hydrocarbons (PAHs) in a sediment core collected from Langkawi Island of the Andaman Sea, Malaysia were determined by GC/MS, the vertical variations of concentration and distributions of PAHs were investigated. In combining with 210Pb-dating, the PAHs sedimentary record in the last 100 years was reconstructed and their possible sources were also discussed. The sigmaPAH concentration ranged from 13.2-60.1 ng x g(-1) in the whole sedimentary section (0-56 cm) with the dominant compounds of phenanthrene, naphthalene and perylene. The sediments contaminated to a lesser extent comparing with the surrounding waters. Before the 1920s, the concentrations of PAHs were considered to be the background level, which was implied from the natural inputs. The historical records of PAHs in the core showed that two distinct peaks which represented the input time of 1960s and 1980s, respectively, inferred that there were some relatively dramatically land-based inputs, and human activities leaded a clear impact to these waters during these periods. Furthermore, PAHs diagnostic ratios indicated that PAHs in the core sediments were mainly of pyrolytic origin (combustion), accompanied with minor petroleum origin. These were related with agriculture, industry, ocean import and export, and shipping activities in the surrounding regions. Meanwhile as the vital communication line, the marine transportation of the Strait of Malacca had influenced the environmental quality of the Andaman Sea. Meanwhile, based on the sedimentary record, PAHs concentrations were found to correlate positively with humanism activities and socioeconomic development (Gross Domestic Production) in the surrounding regions.
Fulltext Multilocus phylogenetic analyses reveal unexpected abundant diversity and significant disjunct distribution pattern of the Hedgehog Mushrooms (Hydnum L.)

Feng B, Wang XH, Ratkowsky D, Gates G, Lee SS, Grebenc T, et al.

Sci Rep, 2016 May 06;6:25586.
PMID: 27151256 DOI: 10.1038/srep25586

Hydnum is a fungal genus proposed by Linnaeus in the early time of modern taxonomy. It contains several ectomycorrhizal species which are commonly consumed worldwide. However, Hydnum is one of the most understudied fungal genera, especially from a molecular phylogenetic view. In this study, we extensively gathered specimens of Hydnum from Asia, Europe, America and Australasia, and analyzed them by using sequences of four gene fragments (ITS, nrLSU, tef1α and rpb1). Our phylogenetic analyses recognized at least 31 phylogenetic species within Hydnum, 15 of which were reported for the first time. Most Australasian species were recognized as strongly divergent old relics, but recent migration between Australasia and the Northern Hemisphere was also detected. Within the Northern Hemisphere, frequent historical biota exchanges between the Old World and the New World via both the North Atlantic Land Bridge and the Bering Land Bridge could be elucidated. Our study also revealed that most Hydnum species found in subalpine areas of the Hengduan Mountains in southwestern China occur in northeastern/northern China and Europe, indicating that the composition of the mycobiota in the Hengduan Mountains reigion is more complicated than what we have known before.
Effects of the crown ether cavity on the performance of anion exchange membranes

Chen JH, Choo YSL, Wang XH, Liu YJ, Yue XB, Gao XL, et al.

J Colloid Interface Sci, 2023 Apr 06;643:62-72.
PMID: 37044014 DOI: 10.1016/j.jcis.2023.04.011

Anion exchange membrane fuel cells (AEMFCs) have emerged as a promising alternative to proton exchange membrane fuel cells (PEMFCs) due to their adaptability to low-cost stack components and non-noble-metals catalysts. However, the poor alkaline resistance and low OH- conductivity of anion exchange membranes (AEMs) have impeded the large-scale implementation of AEMFCs. Herein, the preparation of a new type of AEMs with crown ether macrocycles in their main chains via a one-pot superacid catalyzed reaction was reported. The study aimed to examine the influence of crown ether cavity size on the phase separation structure, ionic conductivity and alkali resistance of anion exchange membranes. Attributed to the self-assembly of crown ethers, the poly (crown ether) (PCE) AEMs with dibenzo-18-crown-6-ether (QAPCE-18-6) exhibit an obvious phase separated structure and a maximum OH- conductivity of 122.5 mS cm-1 at 80 °C (ionic exchange capacity is 1.51 meq g-1). QAPCE-18-6 shows a good alkali resistance with the OH- conductivity retention of 94.5% albeit being treated in a harsh alkali condition. Moreover, the hydrogen/oxygen single cell equipped with QAPCE-18-6 can achieve a peak power density (PPD) of 574 mW cm-2 at a current density of 1.39 A cm-2.