An innovative health information system can be used to support the control of tuberculosis (TB) in Malaysia. The existing system of MyTB has helped in the national TB information management and decision-making process. However, the system can be further enhanced by producing a prototype of Geospatial Tuberculosis Information System (GeoTBiS). It is a geospatial decision support system that was initially proposed in Shah Alam, Selangor. Geospatial data has spatio-temporal characteristics that can be used to understand the basic elements of TB aetiology, while geospatial operations are employed to collect, manage and disseminate the data in a geographical information system (GIS) environment. The disease map and epidemiological risk analysis are produced using a global positioning system (GPS), satellite imagery, geostatistical analysis and web mapping services. This GeoTBiS has demonstrated the geospatial capabilities in enhancing the current system functions, and several recommendations towards a practicable application.