Rapid progress of Information Communication Technology (ICT) will accelerate the distribution of
information from government to the people; however the monopoly of technology ICT services will
lead to inequality of information distribution in between of normal people and disabled people.
Embrace with the inequality of ICT distribution directly make the group of disabled people left behind
at the information age, or the situation also known as digital divide. Hence, this article attempts to
identify and examine the issues facing by disabled people in order to catch up the fast diffusion of ICT.
Information Communication Technology (ICT) is important to measure the development of the nation
and the people. Malaysia as a democratic nation has to deliver equal services to the people without any
boundaries and discrimination. Nowadays, knowledge of Information Communication Technology is
crucial and become one of the measurement tools to maximize work and task. Failure to catch up ICT
movement will cause digital divide, which is the phenomenon of gap exists between people who have
access to ICT and who did not have access. This paper aims to determine the government initiative in
terms of policy, law and regulations, infrastructure, support organization and training, whether it is
appropriate or inappropriate with the needs of disabled people.
Dengue is a potentially deadly disease with no effective drug. An in silico molecular docking was performed using Autodock
4.2.6 to investigate the molecular interactions between protease inhibitors, comprising antibiotic derivatives namely
doxycycline (3), rolitetracycline (5) and a non-steroidal anti-inflammatory drug (NSAID), meclofenamic acid (4), against
the NS2B-NS3 protease from dengue virus-2 (DENV-2). The non-competitive inhibitor (3) showed lower binding energy
(-5.15 kcal/mol) than the predicted competitive inhibitors 4 and 5 (-3.64 and -3.21 kcal/mol, respectively). Structural
analyses showed compound 3 that bound to a specific allosteric site, interacted with Lys74, a significant amino acid
residue bonded to one of the catalytic triad, Asp75. Compounds 4 and 5 showed direct binding with two of the catalytic
triad, His51 and Ser135, hence, predicted to be competitive inhibitors.