Karsinoma tiroid biasanya didiagnoskan berdasarkan kriteria morfologi tertentu. Dalam sesetengah kes, diagnosis yang tepat mungkin sukar apabila ciri-ciri morfologi adalah tidak ketara. Kajian ini menilai kegunaan Hector Battifora Mesothelial-1 (HBME-1) sebagai penanda immunohistokimia untuk membezakan tisu tiroid barah dengan bukan barah dan untuk membandingkan ekspresi HBME-1 dalam pelbagai jenis tisu tiroid. Sensitiviti dan spesifisiti HBME-1 sebagai penanda khusus untuk karsinoma tiroid juga dikaji. Sejumlah 54 kes barah dan 54 kes bukan barah tiroid yang didiagnos di Pusat Perubatan Universiti Kebangsaan Malaysia untuk tempoh tujuh tahun telah dikumpul. Semua kes diwarnai dengan HBME-1 dan dinilai oleh tiga pemerhati bebas. Kes-kes tersebut diberi skor berdasarkan nisbah pewarnaan dan dinilai sebagai skor 0 (kurang daripada 10%), 1+ (10-25%), 2+ (26-50%) atau 3+ (lebih daripada 50%). Di samping itu, perkaitan antara skor bagi kes barah dengan peringkat patologi tumor juga dikaji. HBME-1 menunjukkan ungkapan pewarnaan yang lebih signifikan dalam kes barah berbanding bukan barah (P
Introduction: The purpose of this study was to determine the prevalence of defaulters of immunization, and their associated risk factors among children age 12 to 24 months. Materials and Methods: A cross-sectional study was conducted in all government's maternal child health clinics in District of Kota Kinabalu, Sabah. Data was collected using a standardised questionnaire from July to November 2006. Results: The prevalence rate for defaulting immunization was 16.8% from the 315 respondents. Bivariable analysis showed various significant factors associated with defaulters such as mother’s employment status, family mobility, transportation and cost. Nonetheless, multivariable analysis showed only mother’s age, mother employment status and family size were the significant predictors for defaulting immunization. Immunization that had the highest rate of defaulters was DPT–OPV booster dose (56.6%), followed by MMR immunization (43.4 %) and
DPT-Hib/OPV and Hep B third dose (37.7%).Conclusion: Employed mothers with bigger family size should be more closely monitored and advised to reduce the chance of defaulting on the immunization. Health promotion activities also should focus to these groups of mothers.
Hyperbaric oxygen therapy (HBOT) was established to increase oxygenation and antimicrobial effect that potentially improve the healing of chronic ulcer. Present study aim to assess the effects of HBOT in chronic diabetic foot ulcer (DFU). A total of sixty patients classified according to Wagner 1, 2 or 3 chronic diabetic foot ulcers, were recruited and subsequently divided randomly into two groups; HBOT and control group. All patients underwent the standard treatment for DFU, but for the HBOT group, underwent 20 HBOT sessions, each lasted 80 – 90 mins at 2.5 atmospheres absolute (ATA). White cell count (WCC) and C-reactive protein (CRP) levels were taken during inclusion, at second and fourth week of treatment. Wound sizes were documented at each follow up until six months follow up. SF-36 at one-month post hyperbaric oxygen therapy was used to measure the health-related quality of life. Reduction of WCC and CRP in HBOT group were significant throughout the treatment (p=0.046 and p=0.039, respectively). A total of 26 patients (86.7%) from the HBOT group achieved complete ulcer healing at six months’ follow-up, while 18 patients (60%) in the control group’s ulcer healed completely. Patients treated with HBOT had significantly better mental and physical health constituent of quality of life. It must be emphasised that HBOT is an adjunctive therapy to the standard management of chronic DFU in accelerating wound healing for a better quality of life.
Keywords: oxygenation, quality of life, wound healing
A cross-sectional study was conducted from December 2009 till May 2010 to determine the quality of life and factors influencing it among physically disabled teenagers. Data were collected from 59 physically disabled teenagers using guided questionnaire Short Form 36 (SF-36) and General Health Questionnaires 12 (GHQ 12). Quality of life among physically disabled teenagers is low for most domains of SF-36 as compared to the general Malaysian population. There was significant difference in quality of life among different races (mental health domain) and among different educational level and type of disability (physical functioning domain). There was no significant association between general health domain and other variables. Higher satisfaction in house, school and recreational environment showed a better quality of life. Higher stress level had a lower quality of life. Lack of disabled friendly environment at home, school and recreational places probably contribute to their quality of life. Schools and public places should have more disabled friendly facilities to improve independency and accessibility. Better education and training will increase their independence and enhance self-confidence. More attention and support at this age is important for them to develop interpersonal skills and character for their future.