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  1. Predictive markers of early endothelial dysregulation in type-1 diabetes: a meta-analysis
    Ranasinghe R, Mathai M, Alshawsh MA, Zulli A, Ranasinghe R
    Acta Diabetol, 2024 Nov 11.
    PMID: 39527296 DOI: 10.1007/s00592-024-02401-2
    BACKGROUND: This study identifies a new set of salient risk factors that may trigger danger signals of vascular dysregulation in T1D. Vascular abnormalities and impairment of CVD is a major adverse effect of T1D, particularly affecting children, adolescents and young adults.

    METHODS: The patients of T1D were compared with the healthy control (HC) for the risk factors of vascular dysregulation in published studies from year 2013 to 2023. The PubMed, Web of Science and Google Scholar databases were searched from 1/1/2013 to 1/9/2023. The risk of bias was assessed with the Cochrane (ROBINS-I ) tool, relevant to clinical subjects. A random effects model was followed and analysed by RevMan 5.4 and GraphPad Prism software.

    RESULTS: 80 relevant case-control studies having 7492 T1D patients and 5293 HC were included. The age and sex-matched HC consisted of persons free of disease and not under any medication while clinical subjects of

  2. Global coastal wave storminess
    Lobeto H, Semedo A, Lemos G, Dastgheib A, Menendez M, Ranasinghe R, et al.
    Sci Rep, 2024 Feb 14;14(1):3726.
    PMID: 38355634 DOI: 10.1038/s41598-024-51420-0
    Coastal wave storms pose a massive threat to over 10% of the world's population now inhabiting the low elevation coastal zone and to the trillions of $ worth of coastal zone infrastructure and developments therein. Using a ~ 40-year wave hindcast, we here present a world-first assessment of wind-wave storminess along the global coastline. Coastal regions are ranked in terms of the main storm characteristics, showing Northwestern Europe and Southwestern South America to suffer, on average, the most intense storms and the Yellow Sea coast and the South-African and Namibian coasts to be impacted by the most frequent storms. These characteristics are then combined to derive a holistic classification of the global coastlines in terms of their wave environment, showing, for example, that the open coasts of northwestern Europe are impacted by more than 10 storms per year with mean significant wave heights over 6 m. Finally, a novel metric to classify the degree of coastal wave storminess is presented, showing a general latitudinal storminess gradient. Iceland, Ireland, Scotland, Chile and Australia show the highest degree of storminess, whereas Indonesia, Papua-New Guinea, Malaysia, Cambodia and Myanmar show the lowest.
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