The repercussions of climate change have profound implications for human health, leading to the emergence of climate-related diseases. Recognizing this, the Ministry of Environment and Forestry in Indonesia has established the Climate Village Program to tackle and mitigate the impact of climate change. Despite the implementation of this program, Larangan Village in Candi Sub-district, Sidoarjo Regency, continues to struggle with cases of climate-related diseases. This research aims to assess the impact of waste management on the prevalence of climate-related diseases in Larangan Village. Using a quantitative, analytical, observational approach with a cross-sectional design, the study concentrates on two neighborhoods within Larangan Village. The population consists of 330 families in the 2nd neighborhood (Non-Climate Village Program) and 344 families in the 9th neighborhood (Climate Village Program), with a sample size of 109. The variables under investigation encompass waste management and climate-related diseases. Data collection involves conducting interviews and distributing questionnaires among community members in both neighborhoods. The collected data undergo analysis using Multigroup Analysis SEM PLS with a significance level of 0.05. The findings reveal a significant negative correlation between waste management and climate-related diseases, suggesting that enhanced waste management is linked to a reduced incidence of such diseases in the community.