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Fulltext Enumeration of Escherichia coli from fresh coconut milk in Negeri Sembilan, West Malaysia

Nurul, F. M., Noorlis, A.,, Nurul Ain, H., Suwaibah, M.

International Food Research Journal, 2017;24(1):455-458.
MyJurnal

Escherichia coli is commonly found in the intestinal tract of human and warm-blooded animal.
Shiga toxin-producing Escherichia coli (STEC) serotype O157:H7 are pathogenic and able to
cause serious health problem to human. In this study, the detection of E. coli from raw coconut
milk was carried out by using the most-probable-number (MPN) and streaked plate methods.
A total of 125 samples were purchased randomly from five hypermarkets and 16 wet markets
in Kuala Pilah, Senawang and Seremban, West Malaysia areas. The samples that contaminate
with E. coli were found to be ranging from 2.4x107
MPN/ml. The results
revealed the presence of E. coli in fresh coconut milk from wet markets and hypermarkets in
Negeri Sembilan. Thus, the result showed high health risk and the need for improving hygienic
standard among food handlers. Therefore, public should be aware and always practice proper
food handling.
Changes in auditory memory performance following the use of frequency-modulated system in children with suspected auditory processing disorders

Umat C, Mukari SZ, Ezan NF, Din NC

Saudi Med J, 2011 Aug;32(8):818-24.
PMID: 21858391

To examine the changes in the short-term auditory memory following the use of frequency-modulated (FM) system in children with suspected auditory processing disorders (APDs), and also to compare the advantages of bilateral over unilateral FM fitting.
Fulltext Physicochemical properties of virgin coconut oil extracted from different processing methods

Mansor, T. S. T., Che Man, Y. B., Shuhaimi, M., Abdul Afiq, M. J., Ku Nurul, F. K. M.

International Food Research Journal, 2012;19(3):837-845.
MyJurnal

Virgin Coconut Oils (VCO) were prepared from fresh-dry (grated coconut route), chilling and thawing, enzymatic and fermentation method in this study. All of the VCO produced conformed physicochemically to the standards established by the Asian and Pacific Coconut Community (APCC) and Codex Alimentarius Commission. The highest FA (fatty acid) is lauric acid in all of the VCO and ranged from 46.36 – 48.42 %, while the principal TAG (triacylglycerol) is LaLaLa (La: Lauric) with 17.94 – 19.83 % of the total TAG. Tocopherol analysis showed the presence of beta, gamma and delta tocopherols at low levels. In all, the physicochemical, FA and TAG analyses of the VCO extracted from different methods showed some significant differences, while the tocopherol content does not differ significantly among the different types of extraction methods used.
Fulltext Rapid Discrimination of Halal and Non-halal Pharmaceutical Excipients by Fourier Transform Infrared Spectroscopy and Chemometrics

A Razak NF, Abd Karim RH, Jamal JA, Said MM

J Pharm Bioallied Sci, 2020 Nov;12(Suppl 2):S752-S757.
PMID: 33828373 DOI: 10.4103/jpbs.JPBS_364_19

Introduction: The appendage of "halal" to a product is not just a guarantee that the product is permitted for Muslims, but it has also become favorable lifestyle choice globally. However, the expansion of halal pharmaceutical market was hindered by lack of global halal standards for pharmaceutical ingredients and product integrity analytical methodology.
Objective: This work aimed to explore the possibility of using Fourier-transform infrared (FTIR) spectroscopy and chemometrics to develop multivariate models to authenticate the "halal-ity" of pharmaceutical excipients with controversial halal status (e.g., magnesium stearate).
Materials and Methods: The FTIR spectral fingerprints of the substance were used to build principal component analysis (PCA) models. The effects of different spectral pretreatment processes such as auto-scaling, baseline correction, standard normal variate (SNV), first, and second derivatives were evaluated. The optimization of the model performance was established to ensure the sensitivity, specificity, and accuracy of the predicted models.
Results: Significant peaks corresponding to the properties of the compound were identified. For both bovine and plant-derived magnesium stearate, the peaks associated can be seen within the regions 2900cm-1 (C-H), 2800cm-1 (CH3), 1700cm-1 (C=O), and 1000-1300cm-1 (C-O). There was not much difference observed in the FTIR raw spectra of the samples from both sources. The quality and accuracy of the classification models by PCA and soft independent modeling classification analogy (SIMCA) have shown to improve using spectra optimized by first derivative followed by SNV smoothing.
Conclusion: This rapid and cost-effective technique has the potential to be expanded as an authentication strategy for halal pharmaceuticals.
Fulltext Di-n-butyl-bis-[N-(2-meth-oxy-eth-yl)-N-methyl-dithio-carbamato-κ2S,S']tin(IV): crystal structure and Hirshfeld surface analysis

Mohamad R, Awang N, Kamaludin NF, Jotani MM, Tiekink ER

Acta Crystallogr E Crystallogr Commun, 2017 Feb 01;73(Pt 2):260-265.
PMID: 28217355 DOI: 10.1107/S2056989017001098

The complete mol-ecule of the title compound, [Sn(C4H9)2(C5H10NOS2)2], is generated by a crystallographic mirror plane, with the SnIV atom and the two inner methyl-ene C atoms of the butyl ligands lying on the mirror plane; statistical disorder is noted in the two terminal ethyl groups, which deviate from mirror symmetry. The di-thio-carbamate ligand coordinates to the metal atom in an asymmetric mode with the resulting C2S4 donor set defining a skew trapezoidal bipyramidal geometry; the n-butyl groups are disposed to lie over the longer Sn-S bonds. Supra-molecular chains aligned along the a-axis direction and sustained by methyl-ene-C-H⋯S(weakly coordinating) inter-actions feature in the mol-ecular packing. A Hirshfeld surface analysis reveals the dominance of H⋯H contacts in the crystal.
Efficient synthetic route to heterobimetallic trinuclear complexes [Ln-Mn-Ln] and their single molecule magnetic properties

Ghazali NF, Vignesh KR, Phonsri W, Murray KS, Junk PC, Deacon GB, et al.

Dalton Trans, 2022 Nov 24.
PMID: 36422236 DOI: 10.1039/d2dt02616c

A series of mononuclear lanthanoidate complexes isolated as [Bu4N][Ln(QCl4)] 1Ln (QCl = 5-chloro-8-quinolinolate; Ln = Eu, Gd, Tb, Dy, Ho, and Er) have been prepared, characterised, and used as facile precursors to obtain a series of new heterobimetallic complexes as crystalline materials. Reaction of 1Ln with manganese nitrate forms [Ln2Mn(QCl)8] (2Ln, where Ln = Tb, Dy, Er and Yb) which have been structurally characterised in the cases of 2Tb and 2Yb. The heteroleptic trinuclear complex [Dy3(QCl)8Cl(OH2)], 3, has also been obtained. Compounds 1Dy, 1Tb, and 1Er display slow relaxation of magnetisation below 10K, particularly for the prolate Er3+ ion. These results also suggest that the positive effects of the change from mononuclear to trinuclear lanthanoid complexes enhance their single molecule magnetic (SMM) behaviour, as evidenced by the well resolved frequency dependent AC out-of-phase susceptibility maxima seen in the 2Ln systems, that have been analysed quantitatively. The synthesis used here provides a promising strategy in obtaining heterobimetallic complexes with quinolinolate ligands and also constructing efficient heterobimetallic SMMs.
Fulltext Pulsatile stretch as a novel modulator of amyloid precursor protein processing and associated inflammatory markers in human cerebral endothelial cells

Gangoda SVS, Avadhanam B, Jufri NF, Sohn EH, Butlin M, Gupta V, et al.

Sci Rep, 2018 01 26;8(1):1689.
PMID: 29374229 DOI: 10.1038/s41598-018-20117-6

Amyloid β (Aβ) deposition is a hallmark of Alzheimer's disease (AD). Vascular modifications, including altered brain endothelial cell function and structural viability of the blood-brain barrier due to vascular pulsatility, are implicated in AD pathology. Pulsatility of phenomena in the cerebral vasculature are often not considered in in vitro models of the blood-brain barrier. We demonstrate, for the first time, that pulsatile stretch of brain vascular endothelial cells modulates amyloid precursor protein (APP) expression and the APP processing enzyme, β-secretase 1, eventuating increased-Aβ generation and secretion. Concurrent modulation of intercellular adhesion molecule 1 and endothelial nitric oxide synthase (eNOS) signaling (expression and phosphorylation of eNOS) in response to pulsatile stretch indicates parallel activation of endothelial inflammatory pathways. These findings mechanistically support vascular pulsatility contributing towards cerebral Aβ levels.
Bacteria flora and heavy metals in cultivated oysters Crassostrea iredalei of Setiu Wetland, East Coast Peninsular Malaysia

Najiah M, Nadirah M, Lee KL, Lee SW, Wendy W, Ruhil HH, et al.

Vet Res Commun, 2008 Jun;32(5):377-81.
PMID: 18369732 DOI: 10.1007/s11259-008-9045-y

Slipper oyster Crassostrea iredalei is a species of good demand for its sweet flavor and white coloured flesh. The filter feeding nature predisposes oysters to accumulation of pathogenic and heavy metals in waters impacted by sewage pollutions and may thus render the oysters unfit for human consumption. A study was undertaken to investigate the presence of bacteria flora and heavy metal concentrations in cultivated oysters Crassostrea iredalei at Setiu Wetland, Terengganu, the only source of cultivated oysters in East Coast of Malaysia. A total of 200 slipper oyster samples were analyzed. The bacteria were isolated using non selective agar such as TSA agar and selective agars before they were then identified using conventional methods in combination with BBL Crystal identification kit. Heavy metals such as zinc (Zn), copper (Cu), cadmium (Cd), and lead (Pb) concentrations were determined using atomic absorption spectrophotometry. Results showed that the oysters harbor predominantly Shewanella putrifaciens followed by Vibrio parahaemolyticus, Vibrio vulnificus, Vibrio cholerae, Enterobacter cloacae, Escherichia coli and Chromobacterium violaceum. They also contain high concentration of Zn (785.68 +/- 285.88 microg/g) with the lowest heavy metal was Pb (0.17 +/- 0.15 microg/g), whilst the concentrations of other heavy metals were Cu (38.9 +/- 13.2 microg/g) and Cd (1.60 +/- 0.28 microg/g). The study is very useful to evaluate the type of bacteria and heavy metal present in oyster meat for human consumption.
Application of the Kvaal method for adult dental age estimation using Cone Beam Computed Tomography (CBCT)

Marroquin Penaloza TY, Karkhanis S, Kvaal SI, Nurul F, Kanagasingam S, Franklin D, et al.

J Forensic Leg Med, 2016 Nov;44:178-182.
PMID: 27821308 DOI: 10.1016/j.jflm.2016.10.013

Different non-invasive methods have been proposed for dental age estimation in adults, with the Kvaal et al. method as one of the more frequently tested in different populations. The purpose of this study was to apply the Kvaal et al. method for dental age estimation on modern volumetric data from 3D digital systems. To this end, 101 CBCT images from a Malaysian population were used. Fifty-five per cent were female (n = 55), and forty-five percent were male (n = 46), with a median age of 31 years for both sexes. As tomographs allow the observer to obtain a sagittal and coronal view of the teeth, the Kvaal pulp/root width measurements and ratios were calculated in the bucco-lingual and mesio-distal aspects of the tooth. From these data different linear regression models and formulae were built. The most accurate models for estimating age were obtained from a diverse combination of measurements (SEE ±10.58 years), and for the mesio-distal measurements of the central incisor at level A (SEE ±12.84 years). This accuracy, however is outside an acceptable range in for forensic application (SEE ±10.00 years), and is also more time consuming than the original approach based on dental radiographs.