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Neuroleptic Malignant Syndrome in a Patient with Lithium-induced Nephrogenic Diabetes Insipidus: A Case Report

Ng BZ, Yacob S

Indian J Psychol Med, 2023 Jan;45(1):91-92.
PMID: 36778617 DOI: 10.1177/02537176211045621
Left frontal lobe glioblastoma multiforme masquerading as psychosis: A case report

Ng BZ, Peter JS, Chua SH

Malays Fam Physician, 2023;18:45-100.
PMID: 37719696 DOI: 10.51866/cr.287

Brain tumours often present with a variety of early subtle, non-specific symptoms. This can obscure an organic origin of the illness, which deters timely referral and management. We report a rare case of psychosis in a patient with a left frontal lobe tumour, preceded by 2 months of lethargy and word- finding difficulty with minimal neurological deficits, who was referred to our psychiatric unit from a primary care facility. Blood investigation findings including tumour marker levels were normal. Prompt neuroimaging revealed a left frontal lobe lesion with findings indicating a glioblastoma. The patient was subsequently referred to the neurosurgical team for surgical resection of the tumour. A high index of suspicion is paramount among atypical sociodemographic groups of patients with atypical psychiatric presentations. The primary care setting, which is often the first point of contact for patients, provides an avenue for early detection of such cases and timely referral to the appropriate healthcare system to ensure an optimal outcome.
Fulltext Differential abundance analysis of mesocarp protein from high- and low-yielding oil palms associates non-oil biosynthetic enzymes to lipid biosynthesis

Ooi TE, Yeap WC, Daim LD, Ng BZ, Lee FC, Othman AM, et al.

Proteome Sci, 2015;13:28.
PMID: 26617468 DOI: 10.1186/s12953-015-0085-2

BACKGROUND: The oil palm Elaeis guineensis Jacq. which produces the highest yield per unit land area of the oil crops is the most important commercial oil crop in South East Asia. The fleshy mesocarp of oil palm fruit, where oil is mostly derived from, contains up to 90 % dry weight of oil (one of the most concentrated in plant tissues). Hence, there is attention given to gain insights into the processes of oil deposition in this oil rich tissue. For that purpose, two-dimensional differential gel electrophoresis (DIGE) coupled with western assays, were used here to analyze differential protein levels in genetically-related high-and low-yielding oil palm mesocarps.
RESULTS: From the DIGE comparative analysis in combination with western analysis, 41 unique differentially accumulated proteins were discovered. Functional categorization of these proteins placed them in the metabolisms of lipid, carbohydrate, amino acids, energy, structural proteins, as well as in other functions. In particular, higher abundance of fructose-1,6-biphosphate aldolase combined with reduced level of triosephosphate isomerase and glyceraldehyde-3-phosphate dehydrogenase may be indicative of important flux balance changes in glycolysis, while amino acid metabolism also appeared to be closely linked with oil yield.
CONCLUSIONS: Forty-one proteins in several important biological pathways were identified as exhibiting differential in abundance at critical oil production stages. These confirm that oil yield is a complex trait involving the regulation of genes in multiple biological pathways. The results also provide insights into key control points of lipid biosynthesis in oil palm and can assist in the development of genetic markers for use in oil palm breeding programmes.

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