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  1. Mustafa AA, Raad K, Mustafa NS
    Clin Case Rep, 2015 Nov;3(11):907-11.
    PMID: 26576270 DOI: 10.1002/ccr3.373
    Here, we aimed to assess whether postoperative oral rehabilitation for mandibulectomy patients is necessary to improve patients' general health in terms of health-related quality of life.
  2. Sulaiman NN, Mustafa NS, Ismail M
    Dalton Trans, 2016 Apr 19;45(16):7085-93.
    PMID: 27005483 DOI: 10.1039/c6dt00068a
    The effects of Na3FeF6 catalyst on the hydrogen storage properties of MgH2 have been studied for the first time. The results showed that for the MgH2 sample doped with 10 wt% Na3FeF6, the onset dehydrogenation temperature decreased to 255 °C, which was 100 °C and 162 °C lower than those of the as-milled and as-received MgH2 sample, respectively. The re/dehydrogenation kinetics were also significantly enhanced compared to the un-doped MgH2. The absorption kinetics showed that the as-milled MgH2 only absorbed 3.0 wt% of hydrogen at 320 °C in 2 min of rehydrogenation, but about 3.6 wt% of hydrogen was absorbed within the same period of time after 10 wt% Na3FeF6 was added to MgH2. The desorption kinetics showed that the MgH2 + 10 wt% Na3FeF6 sample could desorb about 3.8 wt% of hydrogen in 10 min at 320 °C. In contrast, the un-doped MgH2 sample desorbed only 0.2 wt% of hydrogen in the same period of time. The activation energy for the decomposition of the as-milled MgH2 was 167.0 kJ mol(-1), and this value decreased to 75.0 kJ mol(-1) after the addition of 10 wt% Na3FeF6 (a reduction by about 92.0 kJ mol(-1)). It is believed that the in situ formation of the active species of NaMgF3, NaF and Fe during the heating process could enhance the hydrogen storage properties of MgH2, due to the catalytic effects of these new species.
  3. Mustafa A, Lung CY, Mustafa NS, Mustafa BA, Kashmoola MA, Zwahlen RA, et al.
    Clin Oral Implants Res, 2016 Mar;27(3):303-9.
    PMID: 25393376 DOI: 10.1111/clr.12525
    OBJECTIVES: To investigate the effect of eicosapentaenoic acid (EPA)-coated Ti implants on osteoconduction in white New Zealand rabbit mandibles.

    MATERIAL AND METHODS: Sandblasted and cleansed planar titanium specimens with a size of 5 × 5 × 1 mm were coated on one side with 0.25 vol% eicosapentaenoic acid (EPA). The other side of the specimens was kept highly polished (the control side). These specimens were inserted in rabbit mandibles. Twelve rabbits were randomly assigned into three study groups (n = 4). The rabbits were sacrificed at 4, 8, and 12 weeks. The harvested specimens with the implants were assessed for new bone formation on both sides of the implant using CBCT, conventional radiographs, and the biaxial pullout test. The results were statistically analyzed by a nonparametric Kruskal-Wallis test and Friedman's test as multiple comparisons and by Brunner-Langer nonparametric mixed model approach (R Software).

    RESULTS: A significant osteoconductive bone formation was found on the EPA-coated Ti implant surface (P < 0.05) at 8 weeks when compared to the polished surface (control). Biaxial pullout test results showed a significant difference (P < 0.05) after 8 and 12 weeks with a maximum force of 243.8 N, compared to 143.25 N after 4 week.

    CONCLUSION: EPA implant coating promoted osteoconduction on the Ti implant surfaces, enhancing the anchorage of the implant to the surrounding bone in white New Zealand rabbits.

  4. Mustafa NS, Yahya MS, Sazelee N, Ali NA, Ismail M
    ACS Omega, 2018 Dec 31;3(12):17100-17107.
    PMID: 31458330 DOI: 10.1021/acsomega.8b02281
    The K2NiF6 catalytic effect on the NaAlH4 dehydrogenation properties was studied in this work. The desorption temperature was studied using temperature-programmed desorption and exhibited a lower onset hydrogen release after doped with different wt % of K2NiF6 (5, 10, 15 and 20 wt %). It was found that the NaAlH4 doped with 5 wt % K2NiF6 showed the optimal value that can reduce the onset desorption temperature of about 160 °C compared to 190 °C for the milled NaAlH4. The NaAlH4 + 5 wt % K2NiF6 sample showed faster desorption kinetics where 1.5 wt % of hydrogen was released in 30 min at 150 °C. In contrast, the milled NaAlH4 only released about 0.2 wt % within the same time and temperature. From the Kissinger analysis, the apparent activation energy was 114.7 kJ/mol for the milled NaAlH4 and 89.9 kJ/mol for the NaAlH4-doped 5 wt % K2NiF6, indicating that the addition of K2NiF6 reduced the activation energy for hydrogen desorption of NaAlH4. It is deduced that the new phases of AlNi, NaF, and KH that were formed in situ during the dehydrogenation process are the key factors for the improvement of dehydrogenation properties of NaAlH4.
  5. Basari N, Mustafa NS, Yusrihan NEN, Yean CW, Ibrahim Z
    Trop Life Sci Res, 2019 Jan;30(1):23-31.
    PMID: 30847031 MyJurnal DOI: 10.21315/tlsr2019.30.1.2
    Ficus plants are commonly planted as ornamentals along roadsides in Malaysia. In 2010, Ficus plants in Kuala Terengganu were found to be attacked by a moth, identified as Trilocha varians. The larvae of this moth fed on Ficus leaves causing up to 100% defoliation. This study was conducted to determine the life cycle of T. varians under two different environmental temperatures and to control this pest using two different insecticides. Our findings showed that there were significant differences in the time taken for eggs to hatch and larval and pupation period between low and high environmental temperatures. Results also showed that fipronil had lower LT50 and LT95 than malathion. This study provides new information on the life history of T. varians under two different conditions and the efficiency in controlling T. varians larvae using insecticides. The results of this study are important for future management in controlling T. varians population especially in Kuala Terengganu, Malaysia.
  6. Al-Ahmad BEM, Kashmoola MA, Mustafa NS, Hassan H, Arzmi MH
    Eur J Dent, 2018 4 17;12(1):120-122.
    PMID: 29657536 DOI: 10.4103/ejd.ejd_322_17
    Objective: This study aimed to investigate the relationship between tooth loss and the level of blood pressure with the hypothesis that tooth loss is associated with the increase of hypertension in postmenopausal women.

    Materials and Methods: Sixty postmenopausal female patients aged 51-68 years were included in the study to assess the relationship between tooth loss and the level of blood pressure. The information including sociodemographics, last menstruation period, hypertension history, and the duration of having tooth loss was recorded. Blood pressure was measured using sphygmomanometer and the number of tooth loss was determined.

    Results: The results showed a more significant tooth loss in hypertension (median: 23 + 4; interquartile range [IQR]: 6) compared to the normotension postmenopausal women (median: 18 + 6; IQR: 12; P < 0.05). Furthermore, obese patients had more tooth loss (median: 23 + 5; IQR: 8) than the overweight patients (median: 19 + 8; IQR: 8).

    Conclusion: Tooth loss is associated with the increase of hypertension in postmenopausal women which may have a role in the development of vascular diseases.

  7. Mustafa NS, Kashmoola MA, Majeed KRA, Qader OAJA
    Eur J Dent, 2018 10 30;12(4):540-545.
    PMID: 30369800 DOI: 10.4103/ejd.ejd_377_17
    Objectives: The aim of this study is to determine the success rate of the endodontically treated teeth in patients attending the Polyclinic, Kulliyyah of Dentistry, International Islamic University Malaysia (IIUM), from 2012 to 2015.

    Materials and Methods: A retrospective study involved endodontically treated teeth of patients attending the Polyclinic, Kulliyyah of Dentistry, IIUM, from 2012 to 2015. Clinical and radiographic data were recorded and classified as successful or failed, and further analyzed by Fisher's exact test to measure the correlation between the variables using SPSS software version 16.0. Kappa test was used to measure the overall relationship between clinical and radiographic findings.

    Results: A total of sixty teeth were evaluated clinically and radiographically, the overall success rate was 85% (n = 51). Correlation between the variables showed nonsignificant (P > 0.05) in the success rate among age, gender, and race, upper and lower arches and between anterior and posterior teeth at the time of treatment. At postendodontic fixed restorations, the variables showed statistically significant relationship with the success rate (P < 0.05).

    Conclusions: Patients with no signs and symptoms and with no radiographical changes at the the time of clinical examination, showed the highest percentage of success rate (85%) of postendodontic fixed restorations. Age, gender, and race have no significant relations with the success rate of endodontically treated teeth.

  8. Mustafa NS, Kashmoola MA, Al-Ahmad BEM, Fansuri MABH, Jurimi NHM, Kashmoola S
    Eur J Dent, 2021 Nov 09.
    PMID: 34753187 DOI: 10.1055/s-0041-1735443
    OBJECTIVE: This study aimed to examine the etiological factors of orofacial pain for patients attending dental clinic at Faculty of Dentistry, International Islamic University Malaysia (IIUM).

    MATERIALS AND METHODS: This retrospective study examined the data of 248 patients who have attended dental clinic at Faculty of Dentistry IIUM and suffering from different types of orofacial pain. The data were collected from January 2010 to November 2018. The etiologies of pain were classified according to International Classification of Orofacial Pain, 1st edition (2020).

    STATISTICAL ANALYSIS: The association of age and gender with orofacial pain was evaluated by using the Chi-square test, and the significance level was set to 0.05.

    RESULTS: Collected data showed that orofacial pain has different etiologies among the patients attending the dental clinic at Faculty of Dentistry IIUM. Moreover, a statistically significant relation was observed between orofacial pain toward gender and different age group.

    CONCLUSION: The findings proposed that the orofacial pain has a variety of etiological factors with the highest percentage of orofacial pain attributed to disorders of dentoalveolar and anatomically related structures among patients attending dental clinic at Faculty of Dentistry IIUM.

  9. Subramaniam PK, Al-Ahmad BEM, Mustafa NS, Izhan NAM, Shukor NFIA
    Eur J Dent, 2023 Jul;17(3):895-901.
    PMID: 36220122 DOI: 10.1055/s-0042-1757212
    OBJECTIVES:  Dental anxiety is ultimately related to the fear of pain, more evidently seen in surgical dental procedures. This study aimed at comparing the stress parameter differences between patients undergoing minor oral surgery (MOS) with their eyes covered (closed) versus uncovered (open) at our center.

    MATERIALS AND METHODS:  Twenty-three MOS patients were draped with eyes covered, while another 23 MOS patients were draped with eyes uncovered. Stress parameters such as systolic and diastolic blood pressures (DBP), mean arterial pressure (MAP), heart rate, random blood glucose, and Spielberger State-Trait Anxiety Inventory (STAI)-6 questionnaire score were recorded accordingly in the different intervals; then statistically analyzed later.

    RESULTS:  Closed eyes patients had significantly lower mean DBP and MAP (73.91 ± 6.80/88.94 ± 6.88 mm Hg) as compared with open eyes patients intraoperatively. Though significant only in the postoperative phase, the closed eyes group had a relatively lower mean heart pulse rate than the open eyes group in all surgical intervals. Postoperatively, closed eyes patients had lower mean blood glucose level as compared with open eyes group. STAI mean score revealed a higher psychological stress for closed eyes patients versus open eyes patients.

    CONCLUSION:  Closed eyes patients displayed lower quantifiable physiological stress level as compared with patients undergoing MOS draped with eyes uncovered. However, in qualitative psychological context, closed eyes draped MOS patients responded poorly as compared with opened eyes draped patients under similar surgical stress.

  10. Murizan NIS, Mustafa NS, Ngadiman NHA, Mohd Yusof N, Idris A
    Polymers (Basel), 2020 Nov 27;12(12).
    PMID: 33261121 DOI: 10.3390/polym12122818
    Nanocrystalline cellulose is an abundant and inexhaustible organic material on Earth. It can be derived from many lignocellulosic plants and also from agricultural residues. They endowed exceptional physicochemical properties, which have promoted their intensive exploration in biomedical application, especially for tissue engineering scaffolds. Nanocrystalline cellulose has been acknowledged due to its low toxicity and low ecotoxicological risks towards living cells. To explore this field, this review provides an overview of nanocrystalline cellulose in designing materials of bone scaffolds. An introduction to nanocrystalline cellulose and its isolation method of acid hydrolysis are discussed following by the application of nanocrystalline cellulose in bone tissue engineering scaffolds. This review also provides comprehensive knowledge and highlights the contribution of nanocrystalline cellulose in terms of mechanical properties, biocompatibility and biodegradability of bone tissue engineering scaffolds. Lastly, the challenges for future scaffold development using nanocrystalline cellulose are also included.
  11. Mustafa NS, Akhmal NH, Izman S, Ab Talib MH, Shaiful AIM, Omar MNB, et al.
    Polymers (Basel), 2021 May 14;13(10).
    PMID: 34069101 DOI: 10.3390/polym13101584
    The design of a scaffold of bone tissue engineering plays an important role in ensuring cell viability and cell growth. Therefore, it is a necessity to produce an ideal scaffold by predicting and simulating the properties of the scaffold. Hence, the computational method should be adopted since it has a huge potential to be used in the implementation of the scaffold of bone tissue engineering. To explore the field of computational method in the area of bone tissue engineering, this paper provides an overview of the usage of a computational method in designing a unit cell of bone tissue engineering scaffold. In order to design a unit cell of the scaffold, we discussed two categories of unit cells that can be used to design a feasible scaffold, which are non-parametric and parametric designs. These designs were later described and being categorised into multiple types according to their characteristics, such as circular structures and Triply Periodic Minimal Surface (TPMS) structures. The advantages and disadvantages of these designs were discussed. Moreover, this paper also represents some software that was used in simulating and designing the bone tissue scaffold. The challenges and future work recommendations had also been included in this paper.
  12. Halim Yap MFAA, Yahya MS, Sazelee N, Ali NA, Mustafa NS, Sulaiman NN, et al.
    ACS Omega, 2021 Jul 27;6(29):18948-18956.
    PMID: 34337234 DOI: 10.1021/acsomega.1c02208
    In this work, the catalytic effects of FeCl3 toward the hydrogen storage properties of the MgH2-Na3AlH6 composite were investigated for the first time. The temperature-programed desorption results indicated that the onset temperature of the hydrogen release of a 10 wt % FeCl3-doped MgH2-Na3AlH6 composite was ∼30 °C lower than that of the undoped MgH2-Na3AlH6 composite. The addition of FeCl3 into the MgH2-Na3AlH6 composite resulted in improved absorption and desorption kinetics performance. The absorption/desorption kinetics measurements at 320 °C (under 33 and 1 atm hydrogen pressure, respectively) indicated that within 10 min, the doped sample absorbed ∼4.0 wt % and desorbed ∼1.5 wt % hydrogen. By comparison, the undoped sample absorbed only ∼2.1 wt % and desorbed only ∼0.6 wt % hydrogen under the same conditions and time. Comparably, the apparent activation energy value of the doped composite is 128 kJ/mol, which is 12 kJ/mol lower than that of the undoped composite (140 kJ/mol). The formation of the new species of MgCl2 and Fe in the doped composite was detected from X-ray diffraction analysis after heating and absorption processes. These two components were believed to play a vital role in reducing the decomposition temperature and kinetics enhancement of the MgH2-Na3AlH6 composite.
  13. Mohd Adnan LH, Abu Bakar NH, Simbak N, Mohamad N, Ismail R, Ahmad NZ, et al.
    Iran J Basic Med Sci, 2020 Jul;23(7):849-852.
    PMID: 32774804 DOI: 10.22038/ijbms.2020.41678.9841
    Opioids, amphetamines, and other types of substances have been widely abused around the world. Opioid dependence and tolerance are two distinct phenomena that have been associated with substance abuse issues. The management of its adverse consequences is becoming more challenging. More and more people are treated in Methadone Maintenance Therapy (MMT) program yet the issues are still unresolved. Researchers are continuing to study the best formulation in treating opioid dependent people starting with modern and alternative drug therapies. Since 2008 , thymoquinone (TQ) has been extensively studied by researchers around the world and has emerged to be a new potential drug candidate in managing substance abuse issues. Thus, the aim of this article is to review the effects that TQ may have on opioid dependent subjects and other abused substances such as amphetamine may have been studied. All of the articles from 2008 until 2019 involving the effects of TQ on substance abuse from Google Scholar®, Scopus®, and Pubmed® databases have been searched and reviewed. The keywords used were thymoquinone, opioid dependence, amphetamine, and Nigella sativa. The research results also have been discussed in this article. Based on the research conducted, TQ was effective in reducing the adverse health consequences associated with substance abuse such as withdrawal symptoms, tolerance, and cell damages. It is concluded that TQ could be a potential drug that can be complemented with the currently available drugs in substance abuse therapies.
  14. Choo SJ, Chang CT, Chan HK, Abu Hassan MR, Hamdan MH, Cheong AT, et al.
    BMC Public Health, 2024 May 14;24(1):1311.
    PMID: 38745185 DOI: 10.1186/s12889-024-18739-9
    INTRODUCTION: Although COVID-19 has entered the endemic phase, individuals infected with COVID-19 are required to adhere to home quarantine measures. By exploring the public's knowledge and attitude towards recommended home quarantine measures, their readiness in containing potential COVID-19 outbreak can be determined. This study aimed to assess the public knowledge and attitude towards home quarantine instructions and their association with history of COVID-19 infections.

    METHODS: This was a web-based cross-sectional study conducted among the public in Malaysia between August to October 2022. All Malaysian adults over 18 years of age were included. Knowledge on home quarantine instructions and COVID-19 warning signs were measured using "True," "False," or "I'm not sure", while attitude towards home quarantine instructions was measured using a five-point Likert Scale. The questionnaire was initially constructed in English and then translated into the national language, Bahasa Malaysia. Face and content validation were performed. The internal consistency of the questionnaire was found to be satisfactory.

    RESULTS: 1,036 respondents were analyzed, comprised mostly of females (743, 71.6%) with a history of COVID-19 (673, 64.9%). In the knowledge domain, more than 80% of the respondents answered 9 out of 11 home quarantine instructions statements correctly. 457 (44.1%) were unaware or unsure about the minimum distance of the infected individual's bed from the rest of the occupants in a shared bedroom. The respondents reported relatively weaker knowledge in identifying uncommon warning signs of COVID-19 deterioration, including anuria (162, 44.5%), ingestion problems (191, 52.5%), and immobility (195, 53.6%). In the attitude domain, more than 90% of respondents answered correctly in 8 out of 9 questions. Respondents with a previous history of COVID-19 infections had better knowledge than COVID-19 infection-naïve individuals towards both home quarantine instructions and COVID-19 warning signs.

    CONCLUSION: Most respondents had good knowledge and attitude towards home quarantine instructions, with those previously infected with COVID-19 showing greater awareness of uncommon warning signs. However, there was a notable lack of awareness regarding physical distancing within shared rooms, appropriate disinfectant use and mobility limitation within the household. This study highlights the knowledge gaps to be improved in future educational campaigns.

  15. Mustafa NS, Bakar NHA, Mohamad N, Adnan LHM, Fauzi NFAM, Thoarlim A, et al.
    Basic Clin Neurosci, 2020 07 01;11(4):381-388.
    PMID: 33613876 DOI: 10.32598/bcn.9.10.485
    N-Methyl-3, 4-methylenedioxyamphetamine (MDMA), or ecstasy is a recreational drug of abuse. It is a synthetic substance that affects the body's systems, which its mechanism of action and treatment should be more investigated. MDMA provides an immediate enjoyable feeling by stimulating the release of neurotransmitters, such as dopamine and serotonin in the brain. Unfortunately, abnormal regulation of the brain neurotransmitters, as well as the increased oxidative stress causes damage to the brain neurons after the MDMA exposure. Only a few studies have been done regarding its treatment. Thus, the treatment of MDMA complications should be further explored mainly by targeting its mechanism of action in the neurotransmitter systems. Hence, this study presents a short review regarding the recent findings on the role of neurotransmitters to cause MDMA neurotoxicity. The results will be useful for future research in elucidating the potential treatment based on the targeted mechanisms to treat the neurotoxic effects of MDMA.
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