MyMedR

Fulltext The Growing Problem of Radiologist Shortage: Malaysia's Perspective

Ramli NM, Mohd Zain NR

Korean J Radiol, 2023 Oct;24(10):936-937.

PMID: 37793663 DOI: 10.3348/kjr.2023.0742

Depression preceding Marchiafava-Bignami disease

Zhen NB, Gaillard F, Walterfang M, Mohd Zain NR, Yoon CK

Aust N Z J Psychiatry, 2021 02;55(2):224-225.

PMID: 32720512 DOI: 10.1177/0004867420945786

Acute necrotizing encephalopathy in a child secondary to dengue fever: A case report

Cheo SW, Low QJ, Teh YG, Rajahram GS, Mohd Zain NR, Chia YK

Med J Malaysia, 2021 Sep;76(5):750-752.

PMID: 34508389

Dengue fever (DF) is an important public health problem, and it is now endemic in more than 100 countries worldwide. Dengue associated neurological complication is estimated to be affecting 0.5 to 6.2% of patients. Even though this is rare, neurological manifestation of DF is an increasingly recognized entity in recent years due to significant mortality and morbidity reported/seen. Reported central nervous system manifestations due to dengue include encephalitis, encephalopathy, myelitis, myositis, acute disseminated encephalomyelitis, Guillain-Barré syndrome, stroke and etc. We report here a case of acute necrotizing encephalopathy secondary to DF in a previously healthy 12-year-old girl.

A case of early-onset familial Alzheimer's disease with both APP and novel PSEN2 mutations presenting with non-amnestic features

Chee KY, Yee OK, Gaillard F, Velakoulis D, Mohd Zain NR, Yogendren L, et al.

Aust N Z J Psychiatry, 2017 Dec;51(12):1252-1253.

PMID: 28762277 DOI: 10.1177/0004867417722642

Tumefactive demyelinating lesions versus CNS neoplasms, a comparative study

Chew SH, Achmad Sankala HB, Chew E, Md Arif MHB, Mohd Zain NR, Hashim H, et al.

Mult Scler Relat Disord, 2023 Nov;79:104992.

PMID: 37717306 DOI: 10.1016/j.msard.2023.104992

BACKGROUND: Differentiating tumefactive demyelinating lesions (TDL) from neoplasms of the central nervous system continues to be a diagnostic dilemma in many cases.

OBJECTIVE: Our study aimed to examine and contrast the clinical and radiological characteristics of TDL, high-grade gliomas (HGG) and primary CNS lymphoma (CNSL).

METHOD: This was a retrospective review of 66 patients (23 TDL, 31 HGG and 12 CNSL). Clinical and laboratory data were obtained. MRI brain at presentation were analyzed by two independent, blinded neuroradiologists.

RESULTS: Patients with TDLs were younger and predominantly female. Sensorimotor deficits and ataxia were more common amongst TDL whereas headaches and altered mental status were associated with HGG and CNSL. Compared to HGG and CNSL, MRI characteristics supporting TDL included relatively smaller size, lack of or mild mass effect, incomplete peripheral rim enhancement, absence of central enhancement or restricted diffusion, lack of cortical involvement, and presence of remote white matter lesions on the index scan. Paradoxically, some TDLs may present atypically or radiologically mimic CNS lymphomas.

CONCLUSION: Careful evaluation of clinical and radiological features helps in differentiating TDLs at first presentation from CNS neoplasms.

Displaying all 5 publications