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  1. Mohd Isa, S., Hashim, A.H., Kaur, M., Ng, C.G.
    MyJurnal
    Objective: As Internet use becomes ubiquitous among adolescents, Internet
    addiction turns out to be as a potential problem in adolescents. The aim of
    this cross-sectional study was to examine the prevalence of internet addiction
    and its associated factors among the adolescents in Malaysia.

    Methods: The
    association between internet addiction and attention deficit hyperactivity
    disorder (ADHD) symptoms was also examined in this cross-sectional study,
    which was conducted at four secondary schools in Malaysia. In this study,
    Malaysian Version of Internet Addiction Test (MVIAT), Conners-Wells
    Adolescent Self-report: Short Form (CASS:S), The Conners Teachers Rating
    Scale: Short Form (CTRS:S) and The Conners’ Parents Rating Scale: Short
    For (CPRS: S) were used.

    Results: The results demonstrated 28.6% of the
    subjects were addicted to the internet and there was a positive association
    with ADHD symptoms. Male gender, early age of first internet use, longer
    total time of internet use are associated with internet addiction problem
    among the adolescents. Internet addiction has become highly prevalent
    among the adolescent in Malaysia.

    Conclusions: It is important to provide
    support for this group of adolescent with internet use problem. Measure to
    prevent the worsening of the situation and future research on the causal
    factors of internet addiction such as ADHD is needed.
  2. Leong Bin Abdullah MFI, Tan KL, Mohd Isa S, Yusoff NS, Chear NJY, Singh D
    PLoS One, 2020;15(6):e0234639.
    PMID: 32525924 DOI: 10.1371/journal.pone.0234639
    BACKGROUND AND AIM: Kratom, or Mitragyna speciosa Korth., is a tropical plant that has been reported to exhibit opioid-like effects. Although opioids have been demonstrated to alter the lipid profile of regular users, data on the lipid-altering effects of kratom are scarce. This study aimed to compare the fasting lipid profile of regular kratom users to that of healthy subjects who do not use kratom. It also determined the association between various characteristics of kratom users and the serum triglycerides, total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels of regular kratom users.

    METHODS: A total of 200 participants (n = 100 kratom users and n = 100 healthy subjects who do not use kratom) were recruited for this analytical cross-sectional study. Data on sociodemographic status, kratom use characteristics, cigarette smoking, physical activity, body mass index (BMI), fasting serum lipid profile, and liver function were collected from all participants.

    RESULTS: The liver parameters of the study participants were within normal range. The serum total cholesterol and LDL of kratom users were significantly lower than those of healthy subjects who do not use kratom. There were no significant differences in the serum triglyceride and HDL levels. However, higher average daily frequency of kratom use and increasing age were associated with increased serum total cholesterol among kratom users. Other kratom use characteristics such as age of first kratom intake, duration of kratom use, and quantity of daily kratom intake were not associated with increased serum triglyceride, total cholesterol, LDL, and HDL levels.

    CONCLUSIONS: Our findings suggest regular kratom consumption was not linked to elevated serum lipids, except when there is a higher frequency of daily kratom intake. However, the study was limited by the small sample size, and hence a more comprehensive study with larger sample size is warranted to confirm the findings.

  3. Abrar SS, Azmel Mohd Isa S, Mohd Hairon S, Yaacob NM, Ismail MP
    Cureus, 2024 Oct;16(10):e71359.
    PMID: 39534844 DOI: 10.7759/cureus.71359
    Cervical cancer is the fourth most common cancer among women worldwide, with particularly high incidence and mortality rates in low- and middle-income countries, with Asia reporting the highest number of cases in 2022. Despite this significant burden, the prognostic factors specific to Asian populations remain underexplored. This scoping review aimed to identify and evaluate prognostic factors associated with cervical cancer outcomes in Asia, focusing on clinical, socio-demographic, and treatment-related variables. The review followed the Arksey and O'Malley framework and included 44 studies published between 2013 and 2023. The majority of research was concentrated in East Asia, particularly in China, Japan, and South Korea. Key prognostic factors affecting overall survival and disease-free survival included tumor size, histology, age, lymphovascular invasion, and lymph node metastasis. Non-squamous cell carcinoma histology, especially adenocarcinoma, was consistently linked to poorer outcomes. Older age and medical comorbidities, such as anemia and diabetes, also negatively impacted survival. Treatment-related factors, though less frequently reported, demonstrated the significance of adjuvant therapy, chemotherapy, and treatment intensity in improving outcomes. This review underscores the complexity of cervical cancer prognosis in Asian populations and highlights the need for targeted research and region-specific interventions to address the rising incidence of cervical cancer. It also highlights the scarcity of research on cervical cancer prognostic factors in West, Central, and South Asian countries. Future research should aim to address the gaps in understanding treatment-related factors and explore the potential for region-specific interventions to improve outcomes in cervical cancer across Asia.
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