Non-invasive imaging modalities for wound assessment have become increasingly popular over the past
two decades. The wounds can be developed superficially or from within deep tissues, depending on the
nature of the dominant risk factors. Developing a reproducible quantitative method to assess woundhealing
status has demonstrated to be a convoluted task. Advances in High-Frequency Ultrasound (HFU)
skin scanners have expanded their application as they are cost-effective and reproducible diagnostic tools
in dermatology, including for the measurement of skin thickness, the assessment of skin tumours, the
estimation of the volume of melanoma and non-melanoma skin cancers, the visualisation of skin structure
and the monitoring of the healing of acute and chronic wounds. Previous studies have revealed that HFU
images carry dominant parameters and depict the phenomena occurring within deep tissue layers during
the wound-healing process. However, the investigations have mostly focussed on the validation of HFU
images, and few studies have utilised HFU imaging in quantitative assessment of wound generation and
healing. This paper is an introductory review of the
important studies proposed by the researchers in
the context of wound assessment. The principles
of dermasonography are briefly explained,
followed by a review of the relevant literature that
investigated the wound-healing process and tissue
structures within the wound using HFU imaging.