“Hacking the Science of Cell Division” was developed to unravel an alternative framework for the misconceptions in meiosis and mitosis among secondary school students. The application of Needham’s Five Phase Constructivism Model which contains an orientation phase, generation of ideas, restructuring ideas, application of ideas, and reflection phase was used to carry out this project. Questionnaires on courseware evaluation were distributed to 123 Form Four students from science stream classes in two different schools in Selangor. The research instrument consisted various attributes, including content, interactivity, navigation, and screen design. The result of each analysed item indicated a mean range between 3.95 and 5.00. It can be concluded from the data analysis that students were generally pleased with the outcomes of the courseware and did not feel that it was a waste of their time. Hence, “Hacking the Science of Cell Division” can be utilised to overcome the misconceptions in meiosis and mitosis among secondary students.