he practice of 5S has been adopted by many organizations as a method to organize the workplace towards reducing waste and improving productivity. Moreover, the practice also promotes a safe and efficient environment in organisations. As safety performance of the workplace is among the key issues in most industries including universities to become world class organizations, this study seeks to address empirically the impact of 5S practice on safety management performance. In this context, a survey questionnaire is employed and distributed to 60 employees of the selected university to examine the employees’ perception on the adoption of 5S practice as well as the impact of 5S practice towards safety management performance. The questionnaires were validated by a pilot test with an acceptable value of Cronbach's alpha. Overall findings highlight there was positive perceptions toward 5S practice among the respondents. The results also revealed that 5S Audit has a very strong positive correlation with safety management performance. Furthermore, 5S Training and Top Management Commitment were (2) factors that strongly correlated to safety management performance. These factors are highly important in contributing toward the success of safety management performance. Additionally, since most of the employees were not exposed with Occupational Safety and Health (OSH), this study reveals moderate negative correlation between compliance to OSH Requirements and safety management performance.