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  1. Osteoporotic fracture healing: potential use of medicinal plants from the tropics
    Abdul Jalil MA, Shuid AN, Muhammad N
    Curr Drug Targets, 2013 Dec;14(14):1651-8.
    PMID: 24354586
    With improvements in living standards and healthcare, life expectancy has been increasing dramatically in most parts of the world. These situations lead to the increase in the reported cases of geriatrics-related diseases such as hypogonadal osteoporosis with skeletal fracture being the ultimate outcome, which eventually causes significant morbidity and mortality. The deficient gonadal hormones, which are the main cause of hypogonadal osteoporosis, could be substituted with hormone replacement therapy to hinder bone loss. However, the artificial hormonal therapy has been linked to grievous conditions such as breast and prostate cancers. In view of the various adverse effects associated with conventional treatment, many researchers are now focusing on finding alternative remedies from nature. This article explores the possibilities of certain medicinal plants native to Malaysia that possess androgenic and antioxidant properties to potentially be used in the treatment of fracture due to osteoporosis in ageing people.
  2. Fulltext Stingless Bee Honey, the Natural Wound Healer: A Review
    Abd Jalil MA, Kasmuri AR, Hadi H
    Skin Pharmacol Physiol, 2017;30(2):66-75.
    PMID: 28291965 DOI: 10.1159/000458416
    BACKGROUND: The stingless bee is a natural type of bee that exists in almost every continent. The honey produced by this bee has been widely used across time and space. The distinctive feature of this honey is that it is stored naturally in the pot (cerumen), thus contributing to its beneficial properties, especially in the wound healing process.

    METHODS: In this article, several studies on stingless bee honey that pointed out the numerous therapeutic profiles of this honey in terms of its antioxidant, antimicrobial, anti-inflammatory, as well as moisturizing properties are reviewed. All of these therapeutic properties are related to wound healing properties.

    RESULTS: Antioxidant in stingless bee honey could break the chain of free radicals that cause a detrimental effect to the wounded area. Furthermore, the antimicrobial properties of stingless bee honey could overcome the bacterial contamination and thus improve the healing rate. Moreover, the anti-inflammatory attribute in this honey could protect the tissue from highly toxic inflammatory mediators. The moisturizing properties of the honey could improve wound healing by promoting angiogenesis and oxygen circulation.

    CONCLUSION: The application of honey to the wound has been widely used since ancient times. As a result, it is essential to understand the pharmacological mechanism of the honey towards the physiology of the wounded skin in order to optimize the healing rate in the future.

  3. Fulltext Role of medicinal plants and natural products on osteoporotic fracture healing
    Abd Jalil MA, Shuid AN, Muhammad N
    Evid Based Complement Alternat Med, 2012;2012:714512.
    PMID: 22973405 DOI: 10.1155/2012/714512
    Popularly known as "the silent disease" since early symptoms are usually absent, osteoporosis causes progressive bone loss, which renders the bones susceptible to fractures. Bone fracture healing is a complex process consisting of four overlapping phases-hematoma formation, inflammation, repair, and remodeling. The traditional use of natural products in bone fractures means that phytochemicals can be developed as potential therapy for reducing fracture healing period. Located closely near the equator, Malaysia has one of the world's largest rainforests, which are homes to exotic herbs and medicinal plants. Eurycoma longifolia (Tongkat Ali), Labisia pumila (Kacip Fatimah), and Piper sarmentosum (Kaduk) are some examples of the popular ethnic herbs, which have been used in the Malay traditional medicine. This paper focuses on the use of natural products for treating fracture as a result of osteoporosis and expediting its healing.
  4. Drug trapping and delivery for Alzheimer's diagnosis
    Jalil MA, Kamoldilok S, Saktioto T, Ong CT, Yupapin PP
    Artif Cells Blood Substit Immobil Biotechnol, 2012 Oct;40(5):303-8.
    PMID: 22384850 DOI: 10.3109/10731199.2012.657203
    In this investigation, a new design based on a PANDA ring resonator as an optical trapping tool for tangle protein, molecular motor storage, and delivery is proposed. The optical vortices are generated and the trapping mechanism is controlled in the same way as the conventional optical tweezers. The trapping force is produced by a combination of the gradient field and scattering photons. The required molecular volume is trapped and moved dynamically within the molecular network. The tangle protein and molecular motor can be transported and delivered to the required destinations for Alzheimer's diagnosis by molecular buffer and bus network.
  5. Optical manipulation of nano-micro needle array for large volume molecular diagnosis
    Aziz MS, Jalil MA, Suwanpayak N, Ali J, Yupapin PP
    Artif Cells Blood Substit Immobil Biotechnol, 2012 Aug;40(4):266-70.
    PMID: 22409282 DOI: 10.3109/10731199.2012.658470
    Optical vorticesare generated and controlled to form trapping tools in the same way as optical tweezers. By using the intense optical vortices generated within the PANDA ring resonator, the required atoms/molecules can be trapped and moved (transported) dynamically within the wavelength router or network. The advantage of the proposed system is that a transmitter and receiver can be formed within the same system, which is available for atoms/molecules storage and transportation based on methods that have been proposed to deliver drugs into cells for specific diagnosis.
  6. Fulltext Generation of THz frequency using PANDA ring resonator for THz imaging
    Jalil MA, Abdolkarim A, Saktioto T, Ong CT, Yupapin PP
    Int J Nanomedicine, 2012;7:773-9.
    PMID: 22359455 DOI: 10.2147/IJN.S27625
    In this study, we have generated terahertz (THz) frequency by a novel design of microring resonators for medical applications. The dense wavelength-division multiplexing can be generated and obtained by using a Gaussian pulse propagating within a modified PANDA ring resonator and an add/drop filter system. Our results show that the THz frequency region can be obtained between 40-50 THz. This area of frequency provides a reliable frequency band for THz pulsed imaging.
  7. Molecular diagnosis using multi drug delivery network and stability
    Jalil MA, Innate K, Suwanpayak N, Yupapin PP, Ali J
    Artif Cells Blood Substit Immobil Biotechnol, 2011 Dec;39(6):357-65.
    PMID: 21999106 DOI: 10.3109/10731199.2011.618134
    By using a pair of tweezers to generate the intense optical vortices within the PANDA ring resonator, the required molecules (drug volumes) can be trapped and moved dynamically within the molecular bus networks, in which the required diagnosis or drug delivery targets can be performed within the network. The advantage of the proposed system is that the proposed diagnostic method can perform within the tiny system (thin film device or circuit), which can be available for a human embedded device for diagnostic use. The channel spacing of the trapped volumes (molecules) within the bus molecular networks can be provided.
  8. Nanoscopic volume trapping and transportation using a PANDA ring resonator for drug delivery
    Jalil MA, Tasakorn M, Suwanpayak N, Ali J, Yupapin PP
    IEEE Trans Nanobioscience, 2011 Jun;10(2):106-12.
    PMID: 21518667 DOI: 10.1109/TNB.2011.2142421
    A novel design of nanoscopic volume transmitter and receiver for drug delivery system using a PANDA ring resonator is proposed. By controlling some suitable parameters, the optical vortices (gradient optical fields/wells) can be generated and used to form the trapping tools in the same way as the optical tweezers. By using the intense optical vortices generated within the PANDA ring resonator, the nanoscopic volumes (drug) can be trapped and moved (transport) dynamically within the wavelength router or network. In principle, the trapping force is formed by the combination between the gradient field and scattering photons, which is reviewed. The advantage of the proposed system is that a transmitter and receiver can be formed within the same system (device), which is called a transceiver, which is available for nanoscopic volume (drug volume) trapping and transportation (delivery).
  9. Acne vulgarism treatment using ultra-short laser pulse generated by micro- and nano-ring resonator system
    Jalil MA, Phelawan J, Aziz MS, Saktioto T, Ong CT, Yupapin PP
    Artif Cells Nanomed Biotechnol, 2013 Apr;41(2):92-7.
    PMID: 22991968 DOI: 10.3109/10731199.2012.700519
    Acne vulgaris is adebilitating dermatologic disease, and is conventionally treated by laser therapy using a microring resonator system. An evolving understanding of laser-tissue interactions involving Propioni bacterium acneproducing porphyrins, and the development of lasers to target the sebaceous glands, has led to the development of an escalating number of laser light for acne treatment. The results show that the full width at half maximum of the proposed laser pulse of 0.15 nm can be generated using a microring resonator system. The power of the laser is 200 W and the wavelength laser is 1,032 nm, which is proposed as a treatment of acne vulgaris diseases.
  10. Ultra-short laser pulse generated by a microring resonator system for cancer cell treatment
    Jalil MA, Ong CT, Saktioto T, Daud S, Aziz MS, Yupapin PP
    Artif Cells Nanomed Biotechnol, 2013 Jun;41(3):152-8.
    PMID: 22947143 DOI: 10.3109/10731199.2012.700520
    A microring resonator (MRRs) system incorporated with a add/drop filter is proposed in which ultra-short single, multi-temporal, and spatial optical soliton pulses are simulated and used to kill abnormal cells, tumors, and cancer. Chaotic signals are generated by a bright soliton pulse within a nonlinear MRRs system. Gold nanoparticles and ultra-short femtosecond/picosecond laser pulses' interaction holds great interest in laser nanomedicine. By using appropriate soliton input power and MRRs parameters, desired spatial and temporal signals can be generated over the spectrum. Results show that short temporal and spatial solitons pulse with FWHM = 712 fs and FWHM = 17.5 pm could be generated. The add/drop filter system is used to generate the high-capacity, ultra-short soliton pulses in the range of nanometer/second and picometer/second.
  11. Fulltext Embedded nanomicro syringe on chip for molecular therapy
    Jalil MA, Suwanpayak N, Kulsirirat K, Suttirak S, Ali J, Yupapin PP
    Int J Nanomedicine, 2011;6:2925-32.
    PMID: 22131837 DOI: 10.2147/IJN.S26266
    A novel nanomicro syringe system was proposed for drug storage and delivery using a PANDA ring resonator and atomic buffer. A PANDA ring is a modified optical add/drop filter, named after the well known Chinese bear. In principle, the molecule/drug is trapped by the force generated by different combinations of gradient fields and scattering photons within the PANDA ring. A nanomicro needle system can be formed by optical vortices in the liquid core waveguide which can be embedded on a chip, and can be used for long-term treatment. By using intense optical vortices, the required genes/molecules can be trapped and transported dynamically to the intended destinations via the nanomicro syringe, which is available for drug delivery to target tissues, in particular tumors. The advantage of the proposed system is that by confining the treatment area, the effect can be decreased. The use of different optical vortices for therapeutic efficiency is also discussed.
  12. Fulltext A novel approach for pineapple leaf fiber processing as an ultimate fiber using existing machines
    Jalil MA, Moniruzzaman M, Parvez MS, Siddika A, Gafur MA, Repon MR, et al.
    Heliyon, 2021 Aug;7(8):e07861.
    PMID: 34485740 DOI: 10.1016/j.heliyon.2021.e07861
    This research aims to study the spinnability of pristine PALF and PALF blended cotton using the existing spinning machines. Apron draft ring spinning frame and flyer jute spinning frame were used to produce 100% PALF yarn and the yarns count were found 121 tex and 138 tex separately. Besides, 90:10 and 80:20 cotton-PALF blended 30 tex yarn spun in a cotton spinning system with different twist factors. With both yarns, two samples; 1/1 plain and 3/1 twill fabrics, were fabricated through equal density. For plain and twill fabric, PALF yarn of 121 tex and 138 tex were used in the warp way, respectively and PALF blended cotton yarn of 60 tex was used in the weft way. Through the study, physio-mechanical properties of the samples were explored and FTIR & XRD patterns were analyzed to perform the task for diversified use as an ultimate fiber in industrial and domestic purposes.
  13. Fulltext Introduction to Photonics: Principles and the Most Recent Applications of Microstructures
    Amiri IS, Azzuhri SRB, Jalil MA, Hairi HM, Ali J, Bunruangses M, et al.
    Micromachines (Basel), 2018 Sep 11;9(9).
    PMID: 30424385 DOI: 10.3390/mi9090452
    Light has found applications in data transmission, such as optical fibers and waveguides and in optoelectronics. It consists of a series of electromagnetic waves, with particle behavior. Photonics involves the proper use of light as a tool for the benefit of humans. It is derived from the root word "photon", which connotes the tiniest entity of light analogous to an electron in electricity. Photonics have a broad range of scientific and technological applications that are practically limitless and include medical diagnostics, organic synthesis, communications, as well as fusion energy. This will enhance the quality of life in many areas such as communications and information technology, advanced manufacturing, defense, health, medicine, and energy. The signal transmission methods used in wireless photonic systems are digital baseband and RoF (Radio-over-Fiber) optical communication. Microwave photonics is considered to be one of the emerging research fields. The mid infrared (mid-IR) spectroscopy offers a principal means for biological structure analysis as well as nonintrusive measurements. There is a lower loss in the propagations involving waveguides. Waveguides have simple structures and are cost-efficient in comparison with optical fibers. These are important components due to their compactness, low profile, and many advantages over conventional metallic waveguides. Among the waveguides, optofluidic waveguides have been found to provide a very powerful foundation for building optofluidic sensors. These can be used to fabricate the biosensors based on fluorescence. In an optical fiber, the evanescent field excitation is employed to sense the environmental refractive index changes. Optical fibers as waveguides can be used as sensors to measure strain, temperature, pressure, displacements, vibrations, and other quantities by modifying a fiber. For some application areas, however, fiber-optic sensors are increasingly recognized as a technology with very interesting possibilities. In this review, we present the most common and recent applications of the optical fiber-based sensors. These kinds of sensors can be fabricated by a modification of the waveguide structures to enhance the evanescent field; therefore, direct interactions of the measurand with electromagnetic waves can be performed. In this research, the most recent applications of photonics components are studied and discussed.
  14. Fulltext Gold nanoparticle trapping and delivery for therapeutic applications
    Aziz MS, Suwanpayak N, Jalil MA, Jomtarak R, Saktioto T, Ali J, et al.
    Int J Nanomedicine, 2012;7:11-7.
    PMID: 22275818 DOI: 10.2147/IJN.S27417
    A new optical trapping design to transport gold nanoparticles using a PANDA ring resonator system is proposed. Intense optical fields in the form of dark solitons controlled by Gaussian pulses are used to trap and transport nanoscopic volumes of matter to the desired destination via an optical waveguide. Theoretically, the gradient and scattering forces are responsible for this trapping phenomenon, where in practice such systems can be fabricated and a thin-film device formed on the specific artificial medical materials, for instance, an artificial bone. The dynamic behavior of the tweezers can be tuned by controlling the optical pulse input power and parameters of the ring resonator system. Different trap sizes can be generated to trap different gold nanoparticles sizes, which is useful for gold nanoparticle therapy. In this paper, we have shown the utility of gold nanoparticle trapping and delivery for therapy, which may be useful for cosmetic therapy and related applications.
  15. Detection of Salmonella bacterium in drinking water using microring resonator
    Bahadoran M, Noorden AF, Mohajer FS, Abd Mubin MH, Chaudhary K, Jalil MA, et al.
    Artif Cells Nanomed Biotechnol, 2016;44(1):315-21.
    PMID: 25133457 DOI: 10.3109/21691401.2014.948549
    A new microring resonator system is proposed for the detection of the Salmonella bacterium in drinking water, which is made up of SiO2-TiO2 waveguide embedded inside thin film layer of the flagellin. The change in refractive index due to the binding of the Salmonella bacterium with flagellin layer causes a shift in the output signal wavelength and the variation in through and drop port's intensities, which leads to the detection of Salmonella bacterium in drinking water. The sensitivity of proposed sensor for detecting of Salmonella bacterium in water solution is 149 nm/RIU and the limit of detection is 7 × 10(-4)RIU.
  16. Fulltext An exploratory simulation study and prediction model on human brain behavior and activity using an integration of deep neural network and biosensor Rabi antenna
    Pham NT, Bunruangses M, Youplao P, Garhwal A, Ray K, Roy A, et al.
    Heliyon, 2023 May;9(5):e15749.
    PMID: 37305516 DOI: 10.1016/j.heliyon.2023.e15749
    The plasmonic antenna probe is constructed using a silver rod embedded in a modified Mach-Zehnder interferometer (MZI) ad-drop filter. Rabi antennas are formed when space-time control reaches two levels of system oscillation and can be used as human brain sensor probes. Photonic neural networks are designed using brain-Rabi antenna communication, and transmissions are connected via neurons. Communication signals are carried by electron spin (up and down) and adjustable Rabi frequency. Hidden variables and deep brain signals can be obtained by external detection. A Rabi antenna has been developed by simulation using computer simulation technology (CST) software. Additionally, a communication device has been developed that uses the Optiwave program with Finite-Difference Time-Domain (OptiFDTD). The output signal is plotted using the MATLAB program with the parameters of the OptiFDTD simulation results. The proposed antenna oscillates in the frequency range of 192 THz to 202 THz with a maximum gain of 22.4 dBi. The sensitivity of the sensor is calculated along with the result of electron spin and applied to form a human brain connection. Moreover, intelligent machine learning algorithms are proposed to identify high-quality transmissions and predict the behavior of transmissions in the near future. During the process, a root mean square error (RMSE) of 2.3332(±0.2338) was obtained. Finally, it can be said that our proposed model can efficiently predict human mind, thoughts, behavior as well as action/reaction, which can be greatly helpful in the diagnosis of various neuro-degenerative/psychological diseases (such as Alzheimer's, dementia, etc.) and for security purposes.
  17. Fulltext Multiband Rabi antenna using nest microstrip add-drop filter (NMADF) for relativistic sensing applications
    Sonasang S, Jamsai M, Jalil MA, Pham NT, Ray K, Angkawisittpan N, et al.
    Heliyon, 2023 Feb;9(2):e13611.
    PMID: 36879752 DOI: 10.1016/j.heliyon.2023.e13611
    A microstrip circuit is designed, constructed, and tested based on the nest microstrip add-drop filters (NMADF). The multi-level system oscillation is generated by the wave-particle behaviors of AC driven along the microstrip ring circular path. The continuous successive filtering is applied via the device input port. The higher-order harmonic oscillations can be filtered, from which the two-level system known as a Rabi oscillation is achieved. The outside microstrip ring energy is coupled to the inside rings, from which the multiband Rabi oscillations can be formed within the inner rings. The resonant Rabi frequencies can be applied for multi-sensing probes. The relationship between electron density and Rabi oscillation frequency of each microstrip ring output can be obtained and used for multi-sensing probe applications. The relativistic sensing probe can be obtained by the warp speed electron distribution at the resonant Rabi frequency respecting the resonant ring radii. These are available for relativistic sensing probe usage. The obtained experimental results have shown that there are 3-center Rabi frequencies obtained, which can be used for 3-sensing probes simultaneously. The sensing probe speeds of 1.1c, 1.4c, and 1.5c are obtained using the microstrip ring radii of 14.20, 20.12, and 34.49 mm, respectively. The best sensor sensitivity of 1.30 ms is achieved. The relativistic sensing platform can be used for many applications.
  18. Corrigendum to "Multiband rabi antenna using nest microstrip add-drop filter (NMADF) for relativistic sensing applications" [Heliyon 9(2) (February 2023) e13611]
    Sonasang S, Jamsai M, Jalil MA, Pham NT, Ray K, Angkawisittpan N, et al.
    Heliyon, 2023 Jul;9(7):e16846.
    PMID: 37539238 DOI: 10.1016/j.heliyon.2023.e16846
    [This corrects the article DOI: 10.1016/j.heliyon.2023.e13611.].
  19. Development of 3D-printed universal adapter in enhancing retinal imaging accessibility
    Latip AAA, Kipli K, Kamaruddin AMNA, Sapawi R, Lias K, Jalil MA, et al.
    3D Print Med, 2024 Jul 19;10(1):23.
    PMID: 39028380 DOI: 10.1186/s41205-024-00231-0
    BACKGROUND: The revolutionary technology of smartphone-based retinal imaging has been consistently improving over the years. Smartphone-based retinal image acquisition devices are designed to be portable, easy to use, and cost-efficient, which enables eye care to be more widely accessible especially in geographically remote areas. This enables early disease detection for those who are in low- and middle- income population or just in general has very limited access to eye care. This study investigates the limitation of smartphone compatibility of existing smartphone-based retinal image acquisition devices. Additionally, this study aims to propose a universal adapter design that is usable with an existing smartphone-based retinal image acquisition device known as the PanOptic ophthalmoscope. This study also aims to simulate the reliability, validity, and performance overall of the developed prototype.

    METHODS: A literature review has been conducted that identifies the limitation of smartphone compatibility among existing smartphone-based retinal image acquisition devices. Designing and modeling of proposed adapter were performed using the software AutoCAD 3D. For the proposed performance evaluation, finite element analysis (FEA) in the software Autodesk Inventor and 5-point scale method were demonstrated.

    RESULTS: Published studies demonstrate that most of the existing smartphone-based retinal imaging devices have compatibility limited to specific older smartphone models. This highlights the benefit of a universal adapter in broadening the usability of existing smartphone-based retinal image acquisition devices. A functional universal adapter design has been developed that demonstrates its compatibility with a variety of smartphones regardless of the smartphone dimension or the position of the smartphone's camera lens. The proposed performance evaluation method generates an efficient stress analysis of the proposed adapter design. The end-user survey results show a positive overall performance of the developed universal adapter. However, a significant difference between the expert's views on the developed adapter and the quality of images is observed.

    CONCLUSION: The compatibility of existing smartphone-based retinal imaging devices is still mostly limited to specific smartphone models. Besides this, the concept of a universal and suitable adapter for retinal imaging using the PanOptic ophthalmoscope was presented and validated in this paper. This work provides a platform for future development of smartphone-based ophthalmoscope that is universal.

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