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Fulltext The dominion of the scholars: a preliminary look into Islām’s civilisational contribution in the premodern region of khurāsān

Muhammad Husni Mohd. Amin

TAFHIM : IKIM Journal of Islam and the Contemporary World, 2020;13(1):85-111.
MyJurnal

The preliminary discussion of this short essay focuses on some of Islām’s intellectual and civilisational contributions in a historical region of Central Asia called Khurāsān. As a starting point, it mentions a number of hadīths (sayings from the Prophet Muḥammad) and athār (sayings of the Holy Prophet’s Companions and their followers) that impute to this region some eschatological importance as well as matters pertaining to the legal aspect of the religion, especially from Muslim Sunnī perspective. As a preliminary discussion and in a non-exhaustive manner, the writing highlights and evaluates a number of important Muslim figures that have emerged from that region along with their respective intellectual and cultural contributions to human civilisation as materialisation of the religion’s aspirations arising from collective understanding of its worldview.
Fulltext Planting Jatropha curcas on constrained land: emission and effects from land use change

Firdaus MS, Husni MH

ScientificWorldJournal, 2012;2012:405084.
PMID: 22545018 DOI: 10.1100/2012/405084

A study was carried out to assess carbon emission and carbon loss caused from land use change (LUC) of converting a wasteland into a Jatropha curcas plantation. The study was conducted for 12 months at a newly established Jatropha curcas plantation in Port Dickson, Malaysia. Assessments of soil carbon dioxide (CO(2)) flux, changes of soil total carbon and plant biomass loss and growth were made on the wasteland and on the established plantation to determine the effects of land preparation (i.e., tilling) and removal of the wasteland's native vegetation. Overall soil CO(2) flux showed no significant difference (P < 0.05) between the two plots while no significant changes (P < 0.05) on soil total carbon at both plots were detected. It took 1.5 years for the growth of Jatropha curcas to recover the biomass carbon stock lost during land conversion. As far as the present study is concerned, converting wasteland to Jatropha curcas showed no adverse effects on the loss of carbon from soil and biomass and did not exacerbate soil respiration.
Fulltext The osteoporosis knowledge, belief and calcium intake behaviour among students in a Medical Sciences University

Wan Ling Chiang, Mohammad Husni Ahmad Jamal

Int J Public Health Res, 2020;10(1):1195-1208.
MyJurnal

This study determines the association between osteoporosis knowledge, health belief and calcium intake behaviour among students in a medical sciences university.
Effects of adding organic materials to an acid sulfate soil on the growth of cocoa (Theobroma cacao L.) seedlings

Shamshuddin J, Muhrizal S, Fauziah I, Husni MH

Sci Total Environ, 2004 May 5;323(1-3):33-45.
PMID: 15081715

Acid sulfate soils having a pH of less than 3.5 are widespread in Malaysia. Some of these soils are planted to cocoa, but the yield is reported to be low due to soil infertility related to Al toxicity. Cocoa growth is sensitive to the presence of Al in the soil. To a certain extent, Al toxicity in soils can be reduced by organic matter application and to a greater extent in iron-poor acid sulfate soil. A study was conducted to determine the efficacy of various types of organic materials easily available in the country to ameliorate acid sulfate soil infertility for growing cocoa seedlings. The treatments were control (nil), lime (3 t/ha), peat (10% w/w), peat plus green manure (10% w/w), peat plus rice straw (10% w/w), peat plus chicken dung (10% w/w) and peat plus POMS (Palm oil mill sludge) (10% w/w). The growth of cocoa seedlings was affected significantly by the presence of Al in the cocoa tissues. As the amount of Al in the leaves increased, the relative top dry weight of cocoa seedlings decreased. Likewise, the relative plant height was negatively correlated with Al in the leaves. Peat as well as peat in combination with green manure, rice straw, chicken dung or palm oil mill sludge was able to reduce Al toxicity in acid sulfate soil; the highest top dry weight of cocoa seedlings were obtained in the peat plus green manure treatment. The best cocoa seedlings root growth was found for the peat treatment alone. The relative top dry weight of cocoa seedlings was negatively correlated with Al(3+) as well as Al(3+)+Al(OH)(2+)+Al(OH)(2)(+) activity in the soil solution. The critical values for Al(3+) and the combination of Al(3+)+Al(OH)(2+)+Al(OH)(2)(+) activity in the soil solution were 10 microM and 15 microM, respectively.
New norms in ophthalmic surgery during the COVID-19 pandemic: A narrative review from a Malaysia tertiary eye care center

Yeoh SH, Yong GY, Husni MA

Eur J Ophthalmol, 2022 Jan;32(1):NP316-NP317.
PMID: 32900222 DOI: 10.1177/1120672120958325
Fulltext EFFECTS OF SALICYLICACID AND SUCROSE SOLUTION ON VASE LIFE OF CUT Antigonon leptopusINFLORESCENCESAND THEIR POTENTIAL AS CUT FLOWERS FOR FLOWER ARRANGEMENT

HAIDAR HARIRI ABU SEMAN, HUSNI HAYATI MOHD RAFDI

UMT Journal of Undergraduate Research, 2019;1(1):80-91.
MyJurnal

Pink Antigonon leptopushave potential to be commercialized as cut flowers for flower arrangement. In order to determine cut inflorescences' vase life, vase solution treatments containing Artificial Tap Water as control, salicyclic acid (SA) at 100, 200, 300 mg/L and combination of 100, 200, 300 mg/L SA with 2% sucrose were conducted. Parameters observed were vase life, relative fresh weight (RFW), vase solution uptake (VSU), flower drop (FD), flower colour, relative water content (RWC) and pH. The results showed that cut inflorescences in vase treatment containing 200 mg/L SA + 2% sucrose and 300 mg/L + 2% sucrose had 1.6 fold longer vase life than the control, showing higher water uptake and reduced flower drop by 28%.
Fulltext Determinants of the halal cosmetics adoption among young consumers in the Klang Valley

Narizan Abdullah, Nor Azaruddin Husni Nuruddin, Ahmad Badri Abdullah

TAFHIM : IKIM Journal of Islam and the Contemporary World, 2020;13(2):55-83.
MyJurnal

The global increase in young consumer population and purchasing power has created a new demand for halal cosmetics product development. In Malaysia, it is now the trend in the industry of cosmetics for local manufacturers to produce halal cosmetic products. As the market growth is rapid, the manufacturers of cosmetics are eager to dominate the market and come up with many product varieties in order to pursue and satisfy customers. However, most consumers are conscious of the ingredients used in the making of cosmetic products. While the introduction of new products may facilitate companies in gaining competitive advantage, the failure rate of local products is high. Therefore, the objectives of this study are to understand the relationship between product characteristics, social influence and individual innovativeness with halal cosmetics adoption among young consumers in the Klang Valley, Malaysia. The sampling of this study comprised 350 respondents using survey questionnaires that were distributed in shopping malls in the Klang Valley. In order to test the model, this study used the structural equation modelling (SEM) technique using partial least squares (PLS) with SmartPLS 3.2.8. The findings of this study show that there is a positive relationship between product characteristics, social influence and individual innovativeness towards halal cosmetics adoption among respondents. This study demonstrates that halal cosmetics adoption is increasing among young consumers. Therefore, cosmetics producers or marketers need to understand the behaviour of young consumers in order to ensure that failure rate can be minimised.
Effects of pyrolysis temperature on the physicochemical properties of empty fruit bunch and rice husk biochars

Claoston N, Samsuri AW, Ahmad Husni MH, Mohd Amran MS

Waste Manag Res, 2014 Apr;32(4):331-9.
PMID: 24643171 DOI: 10.1177/0734242X14525822

Biochar has received great attention recently due to its potential to improve soil fertility and immobilize contaminants as well as serving as a way of carbon sequestration and therefore a possible carbon sink. In this work, a series of biochars were produced from empty fruit bunch (EFB) and rice husk (RH) by slow pyrolysis at different temperatures (350, 500, and 650°C) and their physicochemical properties were analysed. The results indicate that porosity, ash content, electrical conductivity (EC), and pH value of both EFB and RH biochars were increased with temperature; however, yield, cation exchange capacity (CEC), and H, C, and N content were decreased with increasing pyrolysis temperature. The Fourier transform IR spectra were similar for both RH and EFB biochars but the functional groups were more distinct in the EFB biochar spectra. There were reductions in the amount of functional groups as pyrolysis temperature increased especially for the EFB biochar. However, total acidity of the functional groups increased with pyrolysis temperature for both biochars.
Comparison of the carbon-sequestering abilities of pineapple leaf residue chars produced by controlled combustion and by field burning

Leng LY, Husni MH, Samsuri AW

Bioresour Technol, 2011 Nov;102(22):10759-62.
PMID: 21958525 DOI: 10.1016/j.biortech.2011.08.131

This study was undertaken to compare the chemical properties and yields of pineapple leaf residue (PLR) char produced by field burning (CF) with that produced by a partial combustion of air-dried PLR at 340 °C for 3 h in a furnace (CL). Higher total C, lignin content, and yield from CL as well as the presence of aromatic compounds in the Fourier Transform Infrared spectra of the char produced from CL suggest that the CL process was better in sequestering C than was the CF process. Although the C/N ratio of char produced from CL was low indicating a high N content of the char, the C in the char produced from CL was dominated by lignin suggesting that the decomposition of char produced from CL would be slow. To sequester C by char application, the PLR should be combusted in a controlled process rather than by burning in the field.
Towards sustainable use of potassium in pineapple waste

Ahmed OH, Husni MH, Anuar AR, Hanafi MM

ScientificWorldJournal, 2004 Nov 20;4:1007-13.
PMID: 15578124

Due to the 1997/98 haze problem in South-East Asia and the increasing need for sustainable food production and development, the usual management of crop residues (including pineapple wastes) through burning is prohibited. As a result, the need for alternative uses of pineapple wastes in pineapple production has been emphasized. This study investigated an environmentally friendly means of recycling pineapple leaves for agricultural use. Pineapple leaves were shredded and composted in a composting drum for 30 days. Part of the shredded leaves was ashed in a muffle furnace for 4 h. Humic acid (HA), K-fulvate, and K in HA and compost were analyzed using standard procedures. An ash to water ratio of 1:7 was used to extract 0.1 molar (M) KOH from the shredded leaves. The 0.1 M KOH contained 50% K and was able to extract 20% HA from the composted pineapple leaves. Percent K in the fulvate using 0.1 M KOH was 43. Besides serving as a foliar spray (supplement soil application K fertilizers), source of K for freshwater fish (e.g., tilapia), the HA produced can be used as a soil conditioner. Studies show that between 0.05-0.01 g of HA per kg soil retards runoff by 36% in sandy and sandy loam soils. The K-fulvate can be used as a fluid fertilizer. In addition, the pH of 2 of the K-fulvate suggests it could be used to dissolve phosphate rocks, particularly those in the arid regions where high soil pH does not facilitate the dissolution of these important rocks that serve as one of the sources of phosphorus fertilizer in agriculture.
Insights for mfVEPs from perimetry using large spatial frequency-doubling and near frequency-doubling stimuli in glaucoma

Abdullah SN, Sanderson GF, Husni MA, Maddess T

Documenta ophthalmologica. Advances in ophthalmology, 2020 08;141(1):45-55.
PMID: 32034583 DOI: 10.1007/s10633-020-09750-7

PURPOSE: To compare two forms of perimetry that use large contrast-modulated grating stimuli in terms of: their relative diagnostic power, their independent diagnostic information about glaucoma and their utility for mfVEPs. We evaluated a contrast-threshold mfVEP in normal controls using the same stimuli as one of the tests.
METHODS: We measured psychophysical contrast thresholds in one eye of 16 control subjects and 19 patients aged 67.8 ± 5.65 and 71.9 ± 7.15, respectively, (mean ± SD). Patients ranged in disease severity from suspects to severe glaucoma. We used the 17-region FDT-perimeter C20-threshold program and a custom 9-region test (R9) with similar visual field coverage. The R9 stimuli scaled their spatial frequencies with eccentricity and were modulated at lower temporal frequencies than C20 and thus did not display a clear spatial frequency-doubling (FD) appearance. Based on the overlapping areas of the stimuli, we transformed the C20 results to 9 measures for direct comparison with R9. We also compared mfVEP-based and psychophysical contrast thresholds in 26 younger (26.6 ± 7.3 y, mean ± SD) and 20 older normal control subjects (66.5 ± 7.3 y) control subjects using the R9 stimuli.
RESULTS: The best intraclass correlations between R9/C20 thresholds were for the central and outer regions: 0.82 ± 0.05 (mean ± SD, p ≤ 0.0001). The areas under receiver operator characteristic plots for C20 and R9 were as high as 0.99 ± 0.012 (mean ± SE). Canonical correlation analysis (CCA) showed significant correlation (r = 0.638, p = 0.029) with 1 dimension of the C20 and R9 data, suggesting that the lower and higher temporal frequency tests probed the same neural mechanism(s). Low signal quality made the contrast-threshold mfVEPs non-viable. The resulting mfVEP thresholds were limited by noise to artificially high contrasts, which unlike the psychophysical versions, were not correlated with age.
CONCLUSION: The lower temporal frequency R9 stimuli had similar diagnostic power to the FDT-C20 stimuli. CCA indicated the both stimuli drove similar neural mechanisms, possibly suggesting no advantage of FD stimuli for mfVEPs. Given that the contrast-threshold mfVEPs were non-viable, we used the present and published results to make recommendations for future mfVEP tests.
In vitro Inhibitory Effects of Andrographis paniculata, Gynura procumbens, Ficus deltoidea, and Curcuma xanthorrhiza Extracts and Constituents on Human Liver Glucuronidation Activity

Husni Z, Ismail S, Zulkiffli MH, Afandi A, Haron M

Pharmacogn Mag, 2017 Jul;13(Suppl 2):S236-S243.
PMID: 28808386 DOI: 10.4103/pm.pm_299_16

BACKGROUND: Andrographis paniculata, Gynura procumbens, Ficus deltoidea and Curcuma xanthorrhiza are commonly consumed as herbal medicines. However their effects on human liver glucuronidation activity are not yet evaluated.
OBJECTIVE: In this study, we evaluate the inhibitory Effects of Andrographis paniculata, Gynura procumbens, Ficus deltoidea and Curcuma xanthorrhiza extracts and their constituents on human liver glucuronidation activity.
MATERIALS AND METHODS: Herbal extracts (aqueous, methanolic and ethanolic extracts) and their constituents were incubated with human liver microsomes with the addition of UDPGA to initiate the reaction. Working concentrations of herbal extracts and their constituents ranged from 10 μg/mL to 1000 μg/mL and 10 μM to 300 μM respectively. IC50 was determined by monitoring the decrement of glucuronidation activity with the increment of herbal extracts or phytochemical constituent's concentrations.
RESULTS: All herbal extracts inhibited human liver glucuronidation activity in range of 34.69 μg/mL to 398.10 μg/mL whereas for the constituents, only xanthorrhizol and curcumin (constituents of Curcuma xanthorrhiza) inhibited human liver glucuronidation activity with IC50 of 538.50 and 32.26 μM respectively.
CONCLUSION: In the present study, we have proved the capabilities of Andrographis paniculata, Gynura procumbens, Ficus deltoidea and Curcuma xanthorrhiza to interfere with in vitro glucuronidation process in human liver microsomes.
SUMMARY: This study documented the capabilities of Andrographis paniculata, Gynura procumbens, Ficus deltoidea and Curcuma xanthorrhiza to inhibit human liver glucuronidation activity which may affect the metabolism of therapeutic drugs or hazardous toxicants that follow the same glucuronidation pathway. Abbreviations used: UGT: Uridine 5'-diphospho-glucuronosyltransferase; 4-MU: 4-methylumbelliferone; IC50: Half Maximal Inhibitory Concentration; Km: Michaelis constant; Vmax: Maximum velocity.
Fulltext Chitosan-Based Nano Systems for Natural Antioxidants in Breast Cancer Therapy

Herdiana Y, Husni P, Nurhasanah S, Shamsuddin S, Wathoni N

Polymers (Basel), 2023 Jul 05;15(13).
PMID: 37447598 DOI: 10.3390/polym15132953

Breast cancer is a major cause of death globally, accounting for around 13% of all deaths. Chemotherapy, the common treatment for cancer, can have side effects that lead to the production of reactive oxygen species (ROS) and an increase in oxidative stress in the body. Antioxidants are important for maintaining the health of cells and helping the immune system function properly. They play a crucial role in balancing the body's internal environment. Using natural antioxidants is an alternative to mitigate the harmful effects of oxidative stress. However, around 80% of natural antioxidants have limited effectiveness when taken orally because they do not dissolve well in water or other solvents. This poor solubility affects their ability to be absorbed by the body and limits their bioavailability. One strategy that has been considered is to increase their water solubility to increase their oral bioavailability. Chitosan-based nanoparticle (CSNP) systems have been extensively explored due to their reliability and simpler synthesis routes. This review focuses on the various methods of chitosan-based nanoformulation for developing effective oral dosage forms for natural antioxidants based on the pharmacokinetics and pharmacodynamics properties. Chitosan (CS) could be a model, because of its wide use in polymeric NPs research, thus providing a better understanding of the role of vehicles that carry natural antioxidants in maintaining the stability and enhancing the performance of cancer drugs.
Fulltext Current Classification of the Bacillus pumilus Group Species, the Rubber-Pathogenic Bacteria Causing Trunk Bulges Disease in Malaysia as Assessed by MLSA and Multi rep-PCR Approaches

Husni AAA, Ismail SI, Jaafar NM, Zulperi D

Plant Pathol J, 2021 Jun;37(3):243-257.
PMID: 34111914 DOI: 10.5423/PPJ.OA.02.2021.0017

Bacillus pumilus is the causal agent of trunk bulges disease affecting rubber and rubberwood quality and yield production. In this study, B. pumilus and other closely related species were included in B. pumilus group, as they shared over 99.5% similarity from 16S rRNA analysis. Multilocus sequence analysis (MLSA) of five housekeeping genes and repetitive elements-based polymerase chain reaction (rep-PCR) using REP, ERIC, and BOX primers conducted to analyze the diversity and systematic relationships of 20 isolates of B. pumilus group from four rubber tree plantations in Peninsular Malaysia (Serdang, Tanah Merah, Baling, and Rawang). Multi rep-PCR results revealed the genetic profiling among the B. pumilus group isolates, while MLSA results showed 98-100% similarity across the 20 isolates of B. pumilus group species. These 20 isolates, formerly established as B. pumilus, were found not to be grouped with B. pumilus. However, being distributed within distinctive groups of the B. pumilus group comprising of two clusters, A and B. Cluster A contained of 17 isolates close to B. altitudinis, whereas Cluster B consisted of three isolates attributed to B. safensis. This is the first MLSA and rep-PCR study on B. pumilus group, which provides an in-depth understanding of the diversity of these rubber-pathogenic isolates in Malaysia.
Fulltext Phenotypic Antimicrobial Susceptibility of Escherichia coli from Raw Meats, Ready-to-Eat Meats, and Their Related Samples in One Health Context

Adzitey F, Huda N, Shariff AHM

Microorganisms, 2021 Feb 05;9(2).
PMID: 33562804 DOI: 10.3390/microorganisms9020326

Meat is an important food source that can provide a significant amount of protein for human development. The occurrence of bacteria that are resistant to antimicrobials in meat poses a public health risk. This study evaluated the occurrence and antimicrobial resistance of E. coli (Escherichia coli) isolated from raw meats, ready-to-eat (RTE) meats and their related samples in Ghana. E. coli was isolated using the USA-FDA Bacteriological Analytical Manual and phenotypic antimicrobial susceptibility test was performed by the disk diffusion method. Of the 200 examined meats and their related samples, 38% were positive for E. coli. Notably, E. coli was highest in raw beef (80%) and lowest in RTE pork (0%). The 45 E. coli isolates were resistant ≥ 50% to amoxicillin, trimethoprim and tetracycline. They were susceptible to azithromycin (87.1%), chloramphenicol (81.3%), imipenem (74.8%), gentamicin (72.0%) and ciprofloxacin (69.5%). A relatively high intermediate resistance of 33.0% was observed for ceftriaxone. E. coli from raw meats, RTE meats, hands of meat sellers and working tools showed some differences and similarities in their phenotypic antimicrobial resistance patterns. Half (51.1%) of the E. coli isolates exhibited multidrug resistance. The E. coli isolates showed twenty-two different resistant patterns, with a multiple antibiotic resistance index of 0.0 to 0.7. The resistant pattern amoxicillin (A, n = 6 isolates) and amoxicillin-trimethoprim (A-TM, n = 6 isolates) were the most common. This study documents that raw meats, RTE meats and their related samples in Ghana are potential sources of antimicrobial-resistant E. coli and pose a risk for the transfer of resistant bacteria to the food chain, environment and humans.
Fulltext Is therapeutic inertia present in hyperglycaemia, hypertension and hypercholesterolaemia management among adults with type 2 diabetes in three health clinics in Malaysia? a retrospective cohort study

Chew BH, Hussain H, Supian ZA

BMC Fam Pract, 2021 06 11;22(1):111.
PMID: 34116645 DOI: 10.1186/s12875-021-01472-2

BACKGROUND: Good-quality evidence has shown that early glycaemic, blood pressure and LDL-cholesterol control in people with type 2 diabetes (T2D) leads to better outcomes. In spite of that, diseases control have been inadequate globally, and therapeutic inertia could be one of the main cause. Evidence on therapeutic inertia has been lacking at primary care setting. This retrospective cohort study aimed to determine the proportions of therapeutic inertia when treatment targets of HbA1c, blood pressure and LDL-cholesterol were not achieved in adults with T2D at three public health clinics in Malaysia.
METHODS: The index prescriptions were those that when the annual blood tests were reviewed. Prescriptions of medication were verified, compared to the preceding prescriptions and classified as 1) no change, 2) stepping up and 3) stepping down. The treatment targets were HbA1c
Fulltext Maternal hemoglobin change from early pregnancy to second trimester is associated with risk of gestational diabetes mellitus: a retrospective cohort study

Sulhariza HZ, Zalilah MS, Geeta A

Front Nutr, 2023;10:1197485.
PMID: 37396129 DOI: 10.3389/fnut.2023.1197485

INTRODUCTION: The accrual of iron that is reflected in high maternal hemoglobin (Hb) status is increasingly recognized as a risk factor for gestational diabetes mellitus (GDM). Changes in maternal Hb level could also implicate glycemic status in pregnancy. This study aimed to determine the associations between maternal Hb levels and their changes with GDM.
METHODS: In this retrospective cohort study, a total of 1,315 antenatal records of mothers with singleton pregnancies from eight health clinics of a district in the northern region of Peninsular Malaysia who delivered between 1st January 2016-31st December 2017 were analyzed. Data extracted from the records were socio-demographic, anthropometric, obstetrical, and clinical data. Hb levels were extracted at booking (<14 weeks) and second trimester (14-28 weeks). Change in Hb was determined by subtracting the Hb level in the second trimester from the booking Hb level and was categorized as decreased, unchanged, and increased Hb. The associations between maternal Hb levels and their changes with GDM risk were analyzed using multiple regression, adjusting for covariates in four different models. Model 1: maternal age and height. Model 2: covariates of Model 1 added with parity, history of GDM, and family history of diabetes. Model 3: covariates of Model 2 added with iron supplementation at booking. Model 4: covariates of Model 3 added with Hb level at booking.
RESULTS AND DISCUSSIONS: Unchanged Hb level from booking to second trimester was significantly associated with GDM risk in Model 1 (AOR: 2.55; 95% CI: 1.20, 5.44; p
Fulltext Improvement in the mechanical strength of compacted urea fertilizer tablets through die wall lubrication

Intan Soraya Shamsudin, Mohd Shamsul Anuar, Ahmad Husni Mohd. Hanif, Yus Aniza Yusof, Suraya Mohd Tahir

Pertanika Journal of Science & Technology, 2019;27(1):193-203.
MyJurnal

This research was conducted to investigate the compaction performance and mechanical
strength of compacted urea fertilizer in unlubricated and lubricated die systems. The
ground urea 46% N fertilizer was compacted in a 13 mm flat-face cylindrical die set in
both unlubricated and lubricated die systems with vegetable fatty acids and magnesium
stearate as lubricants at various compaction stresses to produce urea fertilizer tablets. In
conclusion, a lubricated die system reduces the frictional effects during the production of
urea fertilizer tablets and also produces a mechanically stronger urea fertilizer tablet than
those produced in an unlubricated die system. In addition, the vegetable fatty acids and
magnesium stearate lubricants are found to improve the compaction performance of urea
fertilizer tablet as well as its mechanical strength.
De-novo mutations and genetic variation in the SCN1A gene in Malaysian patients with generalized epilepsy with febrile seizures plus (GEFS+)

Tan EH, Razak SA, Abdullah JM, Mohamed Yusoff AA

Epilepsy Res, 2012 Dec;102(3):210-5.
PMID: 22944210 DOI: 10.1016/j.eplepsyres.2012.08.004

Generalized epilepsy with febrile seizures plus (GEFS+) comprises a group of clinically and genetically heterogeneous epilepsy syndrome. Here, we provide the first report of clinical presentation and mutational analysis of SCN1A gene in 36 Malaysian GEFS+ patients. Mutational analysis of SCN1A gene revealed twenty seven sequence variants (missense mutation and silent polymorphism also intronic polymorphism), as well as 2 novel de-novo mutations were found in our patients at coding regions, c.5197A>G (N1733D) and c.4748A>G (H1583R). Our findings provide potential genetic insights into the pathogenesis of GEFS+ in Malaysian populations concerning the SCN1A gene mutations.
Fulltext Adaptive Indoor Positioning Model Based on WLAN-Fingerprinting for Dynamic and Multi-Floor Environments

Alshami IH, Ahmad NA, Sahibuddin S, Firdaus F

Sensors (Basel), 2017 Aug 05;17(8).
PMID: 28783047 DOI: 10.3390/s17081789

The Global Positioning System demonstrates the significance of Location Based Services but it cannot be used indoors due to the lack of line of sight between satellites and receivers. Indoor Positioning Systems are needed to provide indoor Location Based Services. Wireless LAN fingerprints are one of the best choices for Indoor Positioning Systems because of their low cost, and high accuracy, however they have many drawbacks: creating radio maps is time consuming, the radio maps will become outdated with any environmental change, different mobile devices read the received signal strength (RSS) differently, and peoples' presence in LOS between access points and mobile device affects the RSS. This research proposes a new Adaptive Indoor Positioning System model (called DIPS) based on: a dynamic radio map generator, RSS certainty technique and peoples' presence effect integration for dynamic and multi-floor environments. Dynamic in our context refers to the effects of people and device heterogeneity. DIPS can achieve 98% and 92% positioning accuracy for floor and room positioning, and it achieves 1.2 m for point positioning error. RSS certainty enhanced the positioning accuracy for floor and room for different mobile devices by 11% and 9%. Then by considering the peoples' presence effect, the error is reduced by 0.2 m. In comparison with other works, DIPS achieves better positioning without extra devices.

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