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  1. El-Badawy IM, Singh OP, Omar Z
    Technol Health Care, 2021;29(1):59-72.
    PMID: 32716337 DOI: 10.3233/THC-202198
    BACKGROUND: The quantitative features of a capnogram signal are important clinical metrics in assessing pulmonary function. However, these features should be quantified from the regular (artefact-free) segments of the capnogram waveform.

    OBJECTIVE: This paper presents a machine learning-based approach for the automatic classification of regular and irregular capnogram segments.

    METHODS: Herein, we proposed four time- and two frequency-domain features experimented with the support vector machine classifier through ten-fold cross-validation. MATLAB simulation was conducted on 100 regular and 100 irregular 15 s capnogram segments. Analysis of variance was performed to investigate the significance of the proposed features. Pearson's correlation was utilized to select the relatively most substantial ones, namely variance and the area under normalized magnitude spectrum. Classification performance, using these features, was evaluated against two feature sets in which either time- or frequency-domain features only were employed.

    RESULTS: Results showed a classification accuracy of 86.5%, which outperformed the other cases by an average of 5.5%. The achieved specificity, sensitivity, and precision were 84%, 89% and 86.51%, respectively. The average execution time for feature extraction and classification per segment is only 36 ms.

    CONCLUSION: The proposed approach can be integrated with capnography devices for real-time capnogram-based respiratory assessment. However, further research is recommended to enhance the classification performance.

  2. Ahmad HAB, El-Badawy IM, Singh OP, Hisham RB, Malarvili MB
    Technol Health Care, 2018;26(4):573-579.
    PMID: 29758955 DOI: 10.3233/THC-171067
    BACKGROUND: Fetal heart rate (FHR) monitoring device is highly demanded to assess the fetus health condition in home environments. Conventional standard devices such as ultrasonography and cardiotocography are expensive, bulky and uncomfortable and consequently not suitable for long-term monitoring. Herein, we report a device that can be used to measure fetal heart rate in clinical and home environments.

    METHODS: The proposed device measures and displays the FHR on a screen liquid crystal display (LCD). The device consists of hardware that comprises condenser microphone sensor, signal conditioning, microcontroller and LCD, and software that involves the algorithm used for processing the conditioned fetal heart signal prior to FHR display. The device's performance is validated based on analysis of variance (ANOVA) test.

    RESULTS: FHR data was recorded from 22 pregnant women during the 17th to 37th week of gestation using the developed device and two standard devices; AngelSounds and Electronic Stethoscope. The results show that F-value (1.5) is less than F𝑐𝑟𝑖𝑡, (3.1) and p-value (p> 0.05). Accordingly, there is no significant difference between the mean readings of the developed and existing devices. Hence, the developed device can be used for monitoring FHR in clinical and home environments.

  3. Singh OP, Vallejo M, El-Badawy IM, Aysha A, Madhanagopal J, Mohd Faudzi AA
    Comput Biol Med, 2021 Sep;136:104650.
    PMID: 34329865 DOI: 10.1016/j.compbiomed.2021.104650
    Due to the continued evolution of the SARS-CoV-2 pandemic, researchers worldwide are working to mitigate, suppress its spread, and better understand it by deploying digital signal processing (DSP) and machine learning approaches. This study presents an alignment-free approach to classify the SARS-CoV-2 using complementary DNA, which is DNA synthesized from the single-stranded RNA virus. Herein, a total of 1582 samples, with different lengths of genome sequences from different regions, were collected from various data sources and divided into a SARS-CoV-2 and a non-SARS-CoV-2 group. We extracted eight biomarkers based on three-base periodicity, using DSP techniques, and ranked those based on a filter-based feature selection. The ranked biomarkers were fed into k-nearest neighbor, support vector machines, decision trees, and random forest classifiers for the classification of SARS-CoV-2 from other coronaviruses. The training dataset was used to test the performance of the classifiers based on accuracy and F-measure via 10-fold cross-validation. Kappa-scores were estimated to check the influence of unbalanced data. Further, 10 × 10 cross-validation paired t-test was utilized to test the best model with unseen data. Random forest was elected as the best model, differentiating the SARS-CoV-2 coronavirus from other coronaviruses and a control a group with an accuracy of 97.4 %, sensitivity of 96.2 %, and specificity of 98.2 %, when tested with unseen samples. Moreover, the proposed algorithm was computationally efficient, taking only 0.31 s to compute the genome biomarkers, outperforming previous studies.
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