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  1. Siti Nurhadis Che Omar, Kien-Hui Chua, Bee See Goh, Muhammad Azhan Ubaidah, Lokman Saim, Khairul Anuar Khairoji, et al.
    Sains Malaysiana, 2018;47:2349-2358.
    The limitation of self-repair and proliferation capacity of chondrocytes in cartilage reconstruction lead to alternative
    search of cell source that can improve the auricular regeneration. Human adipose-derived stem cells (HADSC) are an
    alternative cell source that have unique characteristics to self-renew and differentiate into various tissues making it
    suitable for cell therapy and tissue engineering. This study aimed to examine the chondrogenic differentiation potential of
    (HADSC) in monolayer culture by the presence of different transforming growth factor beta’s, TFG-β1, -β2 and -β3. HADSC
    at passage 3 (1.5 × 105 cell/mL) were cultured in chondrogenic medium containing 5 ng/mL of different transforming
    growth factor beta’s, TFG-β1, -β2 and -β3 for 7, 14 and 21 days. Data analysis was evaluated based on the growth
    rate of cells, cells morphological changed, production of collagen type II and glycosaminoglycan sulphate (sGAG). The
    quantitative RT-PCR was carried out to determine the chondrogenic, fibrogenic and hypertrophic gene expression levels.
    Differentiation of HADSC into chondrocytes using TFG-β indicates the occurrence of the chondrogenesis process. The best
    chondrogenic differentiation was observed in HADSC induced by TFG-β3 through the chondrocytes-like cells morphology
    with cells aggregation and high production of proteoglycan matrices compared to other TGF-βs groups. Additionally,
    the expression of chondrocytes-specific genes such as Type II collagen, Aggrecan core protein, Elastin and Sox 9 was
    high. In conclusion, this study has showed that TGF-β3 is the potential growth factor in producing chondrogenic cells
    for auricular cartilage tissue engineering.
  2. Bee-See G, Anuar NA
    Eur Arch Otorhinolaryngol, 2024 Dec;281(12):6711-6715.
    PMID: 39073435 DOI: 10.1007/s00405-024-08853-0
    INTRODUCTION: To date, recurrent neck abscesses associated with branchial anomalies are treated using a variety of techniques. Management strategies may include various imaging modalities and surgical methods. Endoscopic assessment and electrocauterization are the preferred diagnostic modalities and treatment strategies that have recently gained widespread acceptance and popularity.

    METHODOLOGY AND RESULTS: This was a retrospective review on patients' medical record from 2016 to 2023. Seven patients underwent endoscopic cauterization at our centre, a tertiary academic institution. Five of the patients (71.5%) achieved complete remission. Two patients experienced recurrence within 6 months that necessitated re-cauterization once but subsequently recovered completely. Currently, endoscopic management is the preferred approach compared to the typical open neck excision surgery as it is significantly less invasive, resulting in lesser morbidity and similar success rates. At presentation, all of them had ultrasound neck that suggestive of neck abscess. Computed tomography or magnetic resonance imaging unable to provide adequate information about the side of internal opening of fistula where only 3 out of 7 patients demonstrated tract up to the ipsilateral region of pyriform fossa.

    DISCUSSION: Management outcomes of this limited case series showed the potential benefits of endoscopic cauterization as the minimally invasive therapeutic method for recurrent neck abscesses caused by third and fourth branchial cleft fistulas but also to suggest the possibility as the first diagnostic tool prior to imaging studies.

  3. Bee-See G, Zulkefli NAM, Abdullah A, Umat C, Nor NK, Ismail J, et al.
    Braz J Otorhinolaryngol, 2024;90(4):101423.
    PMID: 38657449 DOI: 10.1016/j.bjorl.2024.101423
    OBJECTIVES: To determine the benefits of cochlear implantation in hearing loss children with multiple disabilities (MD) in terms of auditory outcomes, speech performance, and their quality of life.

    METHODS: This was a cross sectional study from January 2019 to December 2020 in which thirty-one children with hearing loss and multiple disabilities were evaluated. Their improvement in auditory and speech performances were assessed using Categories of Auditory Performance version II (CAP-II) and the Speech Intelligibility Rating (SIR) scales. The assessment was done at 6-month intervals, with the baseline evaluation done at least six months after activation of the implant. Parents were asked to fill the Parents Evaluation of Aural/Oral Performance of Children (PEACH) diary and Perceived Benefit Questionnaire (PBQ) to evaluate the child's quality of life.

    RESULTS: All 31 children have Global Developmental Delay (GDD), with 11 having an additional disability. Both mean CAP-II and SIR scores showed significant improvement with increased hearing age (p 

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