Occupational safety and health (OSH) in Small and Medium Enterprises (SMEs) have not received the proper
attention not only in Malaysia, but also in most countries all over the world, in terms of research or support for
implementation. In Malaysia, many agencies such as the Department of Occupational Safety and Health (DOSH),
Social Safety Organization (SOCSO), National Institute of Occupational Safety and Health (NIOSH) and many more
agencies related to OSH have been in collaborations to conduct and promote a safety working environment and to
protect human rights economically, morally and legally. This research mainly focuses on the implementation of the
occupational safety and health in small and medium industries in the southern region of peninsular of Malaysia. This
exploratory study will be based on conducting a survey to 500 SMEs owners and workers throughout the southern
region of Malaysia to get the in-depth knowledge on how the implementation of safety and health management system
in the SMEs will affect them both morally and economically. A site visit will also be conducted in order to enhance
and to get to know the real situation happening in the real working environment. The results of this study will be used
to make and initial evaluation of the implementations of OSH management system in SMEs and hopefully will help
for future interventions and researches.
Occupational safety and health (OSH) in Small and Medium Enterprises (SMEs) have not received the proper
attention not only in Malaysia, but in most of the countries globally, in terms of research or support for implementation.
This research focuses on the implementation of the occupational safety and health in small and medium industries in
the southern region of peninsular of Malaysia. The objective of this research is to determine the level of awareness of
SME owners and also their employers towards the importance of implementing OSH in their daily tasks. This study
will be based on conducting a survey to 200 SMEs owners and workers throughout the southern region of Malaysia.
The results from this research can be use as a benchmark for other researchers to further enhance the research in this
area.
Organotin complexes are recognized as the biologically active compounds in inducing cancerous cells death at very low doses. To date, organotin compounds currently appear among the most potent candidates in research related to the new anticancer drugs. In this study, new organotin(IV) N-butyl-N-phenyldithiocarbamate compounds have been successfully synthesized between the reaction of N-butylaniline amine with organotin(IV) chloride in 1:2/1:1 molar ratio. All compounds were characterized using the elemental analysis, FT-IR and NMR spectroscopy. The single crystal structure was determined by X-ray single crystal analysis. The elemental analysis showed good agreement with the suggested formula (C4H9)2Sn[S2CN(C4H9)(C6H5)]2 (Compound 1 and 2), (C6H5)2Sn[S2CN(C4H9)(C6H5)]2 (Compound 3) and (C6H5)3Sn[S2CN(C4H9)(C6H5)] (Compound 4). The important infrared absorbance peaks, v (C = N) and v(C = S) were detected in range between 1457-1489 cm(-1) and 951-996 cm(-1), respectively. The chemical shift of carbon in NCS2 group obtained from 13C NMR was found in range 198.86-203.53 ppm. The crystal structure of compound 4 showed that the dithiocarbamate ligand coordinates in a monodentate fashion. It crystallized in monoclinic P2(1)/n space group with the crystal cell parameter: a = 10.0488(1) angstroms, b = 18.0008(2) angstroms, c = 15.2054(2) angstroms, beta = 102.442(1) degrees and R = 0.044. The cytotoxicity (IC50) of these compounds against Jurkat E6.1 and K-562 leukemia cells were in the range between 0.4-0.8 and 1.8-5.3 microM, respectively as assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazholium bromide (MTT) assay. In conclusion, our study demonstrate that all compounds showed potent cytotoxicity towards both cell lines tested with the triphenyltin(IV) compound displayed the greatest effect.
The title compound, [Sn(CH(3))(2)(C(5)H(10)NO(2)S(2))(2)], has crystallographic mirror symmetry (C-Sn-C on mirror plane) and the coordination polyhedron around the Sn atom is a tetrahedron [C-Sn-C 139.3 (2) degrees and S-Sn-S 82.3 (1) degrees ] distorted towards a skew-trapezoidal bipyramid owing to an intramolecular Sn.S contact [3.0427 (6) A]. The molecules are linked into a linear chain by intermolecular O-H.O hydrogen bonds [O.O 2.646 (3) A].