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  1. Madihah Ahmad, Bohari M. Yamin, Azwan Mat Lazim
    MyJurnal
    α-Mangostin was extracted from the pericarp of the Malaysian local Garcinia mangostana linn., The structure was characterised by Infrared red, UV-Visible and Nuclear Magnetic Resonance spectroscopic data. The fluorescence peak at 500nm in ethanol was not observed in PNIPAM microgel solution. The increase of colloidal size of the gel in the presence of α-mangostin was studied by Dynamic Light Scattering and Transmission Electron Microscope. The size of the particle also increases with increasing temperature up to 45⁰C after which it began to shrink. The TEM micrograph at 45°C showed a uniformly structured pattern of the gel occurs in the range of the lowest solution critical temperature.
  2. Lim SL, Ishak Ahmad, Azwan Mat Lazim
    Sains Malaysiana, 2015;44:779-785.
    The purpose of this study was to produce a novel pH sensitive hydrogel with superior thermal stability, composed of
    poly(acrylic acid) (PAA) and cellulose nanocrystal (CNC). CNC was extracted from kenaf fiber through a series of alkali
    and bleaching treatments followed by acid hydrolysis. PAA was then subjected to chemical cross-linking using the crosslinking
    agent (N,N-methylenebisacrylamide) in CNC suspension. The mixture was casted onto petri dish to obtain disc
    shape hydrogel. PAA/cellulose hydrogel with the same composition ratio were also prepared as control. The effect of
    reaction conditions such as the ratio of PAA and CNC on the swelling behavior of the hydrogel obtained towards pH
    was studied. The obtained hydrogel was further subjected to different tests such as thermogravimetric analysis (TGA) to
    study the thermal behavior, Fourier transform infrared for functional group identification and swelling test for swelling
    behavior at different pH. The cross-linking of PAA was verified with FTIR with the absence of C=C double bond. In TGA
    test, PAA/CNC hydrogel showed significantly higher thermal stability compared with pure PAA hydrogel. The hydrogel
    obtained showed excellent pH sensitivity and experienced maximum swelling at pH7. The PAA/CNC hydrogel can be
    developed further as drug carrier
  3. Elmi Sharlina MS, Azwan Mat Lazim, Yaacob WA
    Sains Malaysiana, 2017;46:1549-1555.
    Kanji Dioscorea pentaphylla telah diubah suai dengan pensulfatan dan peneutralan bagi menghasilkan natrium
    kanji sulfat. Tindak balas pensulfatan dilakukan dengan asid sulfurik dalam etanol dan air pada suhu 0o
    C. Darjah
    penukargantian dikira berdasarkan peratus karbon dan sulfur yang ditentukan menggunakan penganalisis unsur CHNS.
    Natrium kanji sulfat yang mempunyai darjah penukargantian dan peratus nisbah berat hasil yang tinggi dipilih dan
    dicirikan dengan spektrum transformasi Fourier inframerah (FT-IR) dan profil pembelauan sinar-X (XRD). Kehadiran
    dua puncak getaran regangan C-O-S dan S=O dalam spektrum FT-IR dan puncak berbeza yang terhasil dalam corak
    difraktogram XRD membuktikan tindak balas berlaku pada struktur kanji. Sifat termal juga ditentukan dengan kalorimeter
    pengimbas pembezaan (DSC) dan analisis termogravimetri (TGA). Natrium kanji sulfat yang dihasilkan mempunyai
    kestabilan termal yang baik kerana mempunyai suhu penguraian pada 265o
    C. Natrium kanji sulfat ini sesuai dijadikan
    bahan tambahan dalam penghasilan hidrogel, organogel dan filem dengan sifat anionik kerana degradasi tidak terjadi
    di bawah suhu ini.
  4. Azwan Mat Lazim, Adil Hakam Osman, Maryam Mokhtarom
    Sains Malaysiana, 2018;47:715-723.
    Kajian ini bertujuan menghasilkan hidrogel responsif berasaskan selulosa bakteria yang diperoleh daripada Nata de
    Coco (NDC) dan asid akrilik (AA). Tiga jenis sampel telah disediakan berdasarkan nisbah NDC:AA iaitu sampel hidrogel
    A [1:1], B [2:1] dan C [3:1]. Pencangkukan AA terhadap molekul NDC menggunakan kaedah pempolimeran radikal
    Gamma (GRP) menghasilkan hidrogel NDC-AA (sumber: 60Co). Kaedah yang menggunakan tenaga yang tinggi ini akan
    menghasilkan radikal bebas seperti OH•, H•, H2O2 dan H2. Kesemua radikal ini menyerang kumpulan berfungsi yang
    terdapat pada NDC dan AA seterusnya menggalakkan proses pencangkukan AA terhadap NDC. Hidrogel B [2:1] dipilih dan
    diuji sebagai penjerap metilena biru (MB) dan perubahan keamatannya telah dianalisis menggunakan spektrofotometer
    UV-VIS. Keputusan yang diperoleh telah diselaraskan dengan dua model isoterma, Langmuir dan Freundlich. Perbandingan
    pemalar bagi kedua-dua model isoterma ini mendapati hidrogel B [2:1] yang dihasilkan telah mematuhi kedua-dua
    model isoterma. Keputusan yang diperoleh ini menyokong keupayaan hidrogel B [2:1] untuk digunakan sebagai penjerap
    alternatif MB yang paling efisien.
  5. Mellissa Andarini, Maryam Mokhtarom, Bohari M. Yamin, Cairuliqbal M. Amin M, Izzati Hassan, Azwan Mat Lazim
    Sains Malaysiana, 2017;46:1789-1795.
    Tujuan kajian ini adalah untuk mengkaji kebolehan hidrogel daripada selulosa bakteria (BC-g-PAA) sebagai pembawa bagi
    menghasilkan nanozarah ferum oksida (FeNps). Hidrogel selulosa telah disintesis menggunakan kaedah pempolimeran
    radikal bebas. Secara umum, kaedah pempolimeran radikal bebas ialah pempolimeran berantai (pempolimeran berion),
    dengan monomer radikal bebas menyerang monomer lain yang ikatannya berganda sehingga membentuk rantai dan
    akan melebarkannya. Nanozarah ferum oksida (FeNps) telah dihasilkan melalui gabungan antara 1 × 10-4 g/mL garam
    ferosenium ke dalam sistem hidrogel, seterusnya agen penurun natrium oksida (NaOH) dengan kepekatan 1 M digunakan
    untuk mendapatkan zarah. Hidrogel di dalam larutan penimbal pada pH10 ialah yang mempunyai nisbah pembengkakan
    tertinggi. Keputusan FTIR menunjukkan bahawa asid akrilik (AA) berjaya dicangkukkan pada jaringan selulosa bakteria
    (SB). Imej hidrogel telah dicirikan melalui analisis mikroskopi elektron imbasan (SEM), diikuti oleh spektroskopi tenaga
    serakan X-ray (SEM-EDX) dalam penentuan peratusan elemen ferum (Fe). Nanozarah berhasil diperolah selepas hidrogel
    dikalsinkan, seterusnya zarah tersebut diuji melalui mikroskopi transmisi elektron (TEM) dan pembelauan sinar-X
    (XRD). Analisis TEM menunjukkan diameter zarah berukuran 5 - 20 nm. Keputusan XRD mengesahkan bahawa zarah
    yang diperoleh ialah ferum oksida (Fe3
    O4
    ) yang terletak pada puncak 2θ; 32°, 35°, 49° and 54°. Semua keputusan yang
    diperoleh menunjukkan bahawa hidrogel berasaskan selulosa bakteria berjaya digunakan sebagai nanoreaktor untuk
    menghasilkan nano zarah ferum oksida (FeNps)
  6. Chin WH, Azwan Mat Lazim, Seng JL, Shazrul Fazry, Umi Kalsum Hussain Zaki
    Sains Malaysiana, 2017;46:1505-1512.
    Vinegar is a liquid product that undergoes both alcoholic and acetous fermentation of sugar (carbohydrate) sources. Soursop (Annona muricata) is easily available in Malaysia throughout the year. However, it is also highly perishable and has a short shelf-life. Therefore, in this research, soursop was used in the production of vinegar, to increase its utilisation and reduce wastage. The objectives of this research were to determine the effects of fermentation time and pH on soursop vinegar using a 3 × 5 factorial design and to determine its chemical compositions. It was found that pH and fermentation time showed significant (p<0.05) effects on the reduction of sugar content and the production of acetic acid, while only fermentation time showed a significant effect on the production of ethanol. The interaction between factors did not exhibit any statistical significance (p>0.05). It was evident that the sugar concentration reduces over time and it was inversely proportional to the ethanol and acetic acid concentrations, due to the conversion of sugar to ethanol and subsequently acetic acid. It was found that higher pH (pH5.5) gave significantly (p<0.05) higher acetic acid production in the vinegar, while pH has no significant (p>0.05) effect on ethanol production. There were no significant differences (p>0.05) in vitamin C content in all vinegar samples. Thus, it can be established that at fermentation time of 120 h and pH5.5, more sugar was used and more ethanol and acetic acid were produced.
  7. Adil Hakam, M. Suzeren M. Jamil, Rizafizah Othaman, Azwan Mat Lazim, Abdul Rahman I, Mohamad Amin M
    Sains Malaysiana, 2015;44:827-834.
    In this study, Bacterial cellulose (BC) grafted with Acrylic acid (AA) was prepared using Co60 γ-rays source (30 KGy).
    Although many samples were prepared, BC: AA with ratio of 1:1 labelled as A1 and 2:1 labelled as A2 gave the most
    significant results. Hence these particular ratios have been selected and further investigated. AA was proven grafted onto
    BC by using ATR-FTIR due to the absent of C-O stretching (1040 cm-1) in both hydrogels. The SEM image of both hydrogels
    samples showed highly porosity networks structure have been produced. The physical properties of the hydrogels such
    as equilibrium water content (%) and swelling ratio (%) in different pH buffer solution were measured. It was found
    that the equilibrium water content (%) of A1 was 93.10% while A2 was 74.83%, respectively. The results indicated that
    the equilibrium water content (%) increased by gaining the AA concentration. At pH10, the A2 swelling ratio (%) was
    two folded with 3350% in comparison with the A1. For the removal of methylene blue (MB) from aqueous solution, the
    results from the UV-VIS spectroscopy demonstrated that the A2 sample hydrogel was also an effective absorbent material
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