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  1. Genderwise clinical response of antipsychotics among schizophrenic patients: a prospective observational study from Lahore, Pakistan
    Asif U, Saleem Z, Yousaf M, Saeed H, Hashmi FK, Islam M, et al.
    Int J Psychiatry Clin Pract, 2018 Sep;22(3):177-183.
    PMID: 29082784 DOI: 10.1080/13651501.2017.1395055
    OBJECTIVE: The study was aimed to evaluate the gender specific response to adherence and occurrence of side effects among schizophrenic patients in Lahore, Pakistan.

    METHODS: A prospective study was performed for a period of 1 year among 180 newly diagnosed schizophrenics, aged 20-60 years to observe the symptoms, medication adherence and side effects. Morisky-Green-Levine Scale was used to evaluate medication adherence, LUNSER for side effects and PANSS to measure positive and negative symptoms. Data were analyzed using SPSS.

    RESULTS: Positive symptoms (Male: Baseline 36.14 vs. endpoint 23.58, Female: 35.29 vs. 23.74) and negative symptoms (Males 27.9 vs. 20.05, Females 28.41 vs. 20.2) of schizophrenia were equally reduced after a follow up of 1 year in both the genders. Male population suffered more accumulative side effects (11.4 in males vs. 6.40 in females), extrapyramidal symptoms such as tardive dyskinesia and tremors (1.21 in males vs. 0.57 in females) and other side effects as compared to women (p ≤ .005). Males were found poorly adherent to antipsychotic treatment than females (93.3% in males vs. 6.7% in females (p ≤ .005).

    CONCLUSIONS: Prescribing practices should not overlook sex specific factors like hormonal changes, altered brain morphology and socioeconomic factors that may be responsible for the difference in the response to the course of schizophrenia.

  2. Fulltext Pattern of inappropriate antibiotic use among hospitalized patients in Pakistan: a longitudinal surveillance and implications
    Saleem Z, Saeed H, Hassali MA, Godman B, Asif U, Yousaf M, et al.
    Antimicrob Resist Infect Control, 2019;8:188.
    PMID: 31768252 DOI: 10.1186/s13756-019-0649-5
    Background: The inappropriate use of antibiotics in hospitals increases resistance, morbidity, and mortality. Little is currently known about appropriate antibiotic use among hospitals in Lahore, the capital city of Pakistan.

    Methods: Longitudinal surveillance was conducted over a period of 2 months among hospitals in Lahore, Pakistan. Antibiotic treatment was considered inappropriate on the basis of a wrong dosage regimen, wrong indication, or both based on the British National Formulary.

    Results: A total of 2022 antibiotics were given to 1185 patients. Out of the total prescribed, approximately two-thirds of the study population (70.3%) had at least one inappropriate antimicrobial. Overall, 27.2% of patients had respiratory tract infections, and out of these, 62.8% were considered as having inappropriate therapy. Cephalosporins were extensively prescribed among patients, and in many cases, this was inappropriate (67.2%). Penicillins were given to 283 patients, out of which 201 (71.0%) were prescribed for either the wrong indication or dosage or both. Significant variations were also observed regarding inappropriate prescribing for several antimicrobials including the carbapenems (70.9%), aminoglycosides (35.8%), fluoroquinolones (64.2%), macrolides (74.6%) and other antibacterials (73.1%).

    Conclusion: Educational interventions, institutional guidelines, and antimicrobial stewardship programs need to be developed to enhance future appropriate antimicrobial use in hospitals in Pakistan. Policies by healthcare and Government officials are also needed to minimize inappropriate antibiotic use.

  3. Fulltext Experimental study on the eco-friendly plastic-sand paver blocks by utilising plastic waste and basalt fibers
    Iftikhar B, Alih SC, Vafaei M, Ali M, Javed MF, Asif U, et al.
    Heliyon, 2023 Jun;9(6):e17107.
    PMID: 37484238 DOI: 10.1016/j.heliyon.2023.e17107
    Plastic waste poses a significant hazard to the environment as a result of its high production rates, which endanger both the environment and its inhabitants. Similarly, another concern is the production of cement, which accounts for roughly 8% of global CO2 emissions. Thus, recycling plastic waste as a replacement for cementitious materials may be a more effective strategy for waste minimisation and cement elimination. Therefore, in this study, plastic waste (low-density polyethylene) is utilised in the production of plastic sand paver blocks without the use of cement. In addition to this, basalt fibers which is a green industrial material is also added in the production of eco-friendly plastic sand paver blocks to satisfy the standard of ASTM C902-15 of 20 N/mm2 for the light traffic. In order to make the paver blocks, the LDPE waste plastic was melted outside in the open air and then combined with sand. Variations were made to the ratio of LDPE to sand, the proportion of basalt fibers, and sand particle size. Paver blocks were evaluated for their compressive strength, water absorption, and at different temperatures. Including 0.5% percent basalt fiber of length 4 mm gives us the best result by enhancing compressive strength by 20.5% and decreasing water absorption by 50.5%. The best results were obtained with a ratio of 30:70 LDPE to sand, while the finest sand provides the greatest compressive strength. Moreover, the temperature effect was also studied from 0 to 60 °C, and the basalt fibers incorporated in plastic paver blocks showed only a 20% decrease in compressive strength at 60 °C. This research has produced eco-friendly paver blocks by removing cement and replacing it with plastic waste, which will benefit the environment, save money, reduce carbon dioxide emissions, and be suitable for low-traffic areas, all of which contribute to sustainable development.
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