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Radioecological perspective: The concentration of natural radionuclides around the coast of PLTU Labuan

Priasetyono Y, Amalia NN, Harafiah AA, Sutanto, Prihatiningsih WR

Mar Pollut Bull, 2024 Aug 20;207:116865.
PMID: 39168090 DOI: 10.1016/j.marpolbul.2024.116865

The utilization of coal in Power Plants (PLTUs) can lead to the generation of fly ash waste, which may contain natural radionuclides that can potentially contaminate the surrounding environment. Despite Labuan PLTU's land-coastal location, marine environment monitoring remains minimal. A recent study conducted sediment and seawater sampling, revealing varying levels of natural radionuclides 226Ra, 232Th, and 40K ranging from 3.4 to 27.5 Bq kg-1, 3.9 to 34.9 Bq kg-1, and 64.0 to 275.0 Bq kg-1 in sediments, respectively. Meanwhile, the activity concentration of natural radionuclides 226Ra and 232Th in seawater ranges from 0.5 to 1.1 Bq L-1 to 0.7-1.5 Bq L-1, respectively. These findings provide baseline data for marine radiation levels around PLTU Labuan. Additionally, risk assessments were conducted, indicating Raeq, Hin, and Hex ranges of 13.80-91.00 Bq kg-1, 0.04-0.25, and 0.05-0.31, respectively. The study concludes that Labuan's radiation levels are within safe limits for exposure.
Fulltext The end of catheter dislodgement? Three facile steps to secure a tunneled central venous catheter

Dayang Anita, A. A., Gendeh, H. S., Gendeh, M. K., Kosai, N. R., Mohd Ramzisham, A. R., Reynu R.

Medicine & Health, 2017;12(2):375-377.
MyJurnal

Kateter Vena Cenral boleh tercabut dengan senang daripada tubuh badan.
Artikel ini membincang tiga teknik terperinci yang berinovasi untuk mengelakkan
berlakunya insiden kateter tercabut. Penempatan leher kateter kira-kira 1cm dari
tempat kateter keluar pada bahagian kulit dengan jahitan tambahan di bahagian
leher kateter membantu mencegah insiden kateter tercabut.
Fulltext Perforation of duodeno-jejunal junction in an 8-month-old infant: a management challenge to a general surgeon

Limi L, Anita AA, Liew NC, Safian M

Med J Malaysia, 2011 Jun;66(2):158-9.
PMID: 22106704 MyJurnal

We report a case of perforation over duodeno-jejunal junction (DJ) in a healthy 8-month-old baby. The difficulty in diagnosis, management dilemma and probable etiology is discussed.
Fulltext Mutations in KIF27, GNAS and IFT140 genes in a patient with VACTERL association: a case report

Siti Aishah Sulaiman, Nor Azian Abdul Murad, Chow, Yock Ping, Zam Zureena Mohd Rani, Salwati Shuib, Dayang Anita A. Aziz, et al.

Asia-Pacific Journal of Molecular Medicine, 2018;8(2):1-10.
MyJurnal

VACTERL association is a rare genetic disorder involving at least three of the following congenital
malformations: vertebral defects (V), anal atresia (A), cardiac defects (C), trachea-oesophageal fistula with
or without oesophageal atresia (TE), renal anomalies (R) and limb abnormalities (L). Until now, the
aetiology of VACTERL association is unknown, particularly at the molecular level. Here, we performed
whole exome sequencing (WES) of an infant with VACTERL association. The patient was delivered
prematurely at 30 weeks and had 4/6 of the VACTERL malformations. Trio-WES analysis was performed
using Torrent Suite and ANNOVAR. Polymorphisms with an allele frequency of >0.01 were excluded, and
the remaining variants were filtered based on de novo mutations, autosomal recessive, X-linked and di-genic
inheritance traits. In this patient, no homozygous, compound heterozygous or X-linked mutations was
associated with VACTERL. However, we identified two heterozygous mutations; KIF27
(ENST00000297814: c.3004A> C:p.N1002H) and GNAS (ENST00000371098: c.205C>A:p.H69N) genes that
were inherited from her father and mother respectively. A de novo, IFT140 gene mutation
(ENST00000426508: c.683C>G:p.S228C) was also identified in this patient. The VACTERL phenotype in
this patient may due to heterozygous mutations affecting KIF27 and GNAS genes, inherited via autosomal
recessive trait. In addition, the IFT140 gene mutation may also be involved. These genes are known to be
directly or non-directly involved in the sonic hedgehog signalling that is known to be implicated in
VACTERL. This is the first report of these genetic mutations in association with VACTERL.
Knowledge of blood-borne infectious diseases and the practice of universal precautions amongst health-care workers in a tertiary hospital in Malaysia

Hamid MZ, Aziz NA, Anita AR, Norlijah O

Southeast Asian J Trop Med Public Health, 2010 Sep;41(5):1192-9.
PMID: 21073041

This study aimed to assess the knowledge of blood-borne diseases transmitted through needle stick injuries amongst health-care workers in a tertiary teaching hospital. We also aimed to assess the practices of universal precautions amongst these workers and its correlation with the facts. We carried out a cross-sectional study from January to July 2008 involving various levels of health-care workers in Serdang Hospital, Selangor, Malaysia. A self-administered questionnaire assessing knowledge of blood-borne diseases and universal precautions, and actual practice of universal precautions was used. Two hundred fifteen respondents participated in this study; 63.3% were staff nurses. The mean knowledge score was 31.84 (SD 4.30) and the mean universal practice score was 9.0 (SD 2.1). There was a small, positive correlation between knowledge and actual practice of universal precautions (r = 0.300, n = 206, p < 0.001) amongst the cohort studied. Factors such as age and years of experience did not contribute towards acquisition of knowledge about blood-borne illnesses or the practice of universal precautions.
Fulltext Embelin Alleviates Severe Airway Inflammation in OVA-LPS-Induced Rat Model of Allergic Asthma

Azman S, Sekar M, Wahidin S, Gan SH, Vaijanathappa J, Bonam SR, et al.

J Asthma Allergy, 2021;14:1511-1525.
PMID: 34938083 DOI: 10.2147/JAA.S298613

BACKGROUND: Asthma is a chronic lung disease, which causes wheezing, tightness in the chest, shortness of breath and coughing. In the wake of coronavirus disease 2019 (COVID-19), which affect the lungs, asthma patients are at high risk. Embelin, a natural benzoquinone obtained mainly from Embelia ribes Burm, has excellent biological properties, including protection against acute asthma. However, since asthma is a chronic and multi-factorial inflammatory disease, asthma conferred by a single allergen in an animal may not be clinically significant. Therefore, the purpose of the current study was to evaluate the effectiveness of embelin against ovalbumin (OVA)-lipopolysaccharide (LPS)-induced severe airway inflammation in experimental animals and to investigate the plausible mechanism of action.
METHODS: Rats (n=36) were divided into six groups. Group I served as a normal control. Groups II-VI were sensitised with severe allergens (OVA and LPS) on day 7, 14 and 21, followed by OVA and LPS challenge for 30 min three times/week for 3 weeks. Group II acted as an asthmatic disease control and received only vehicle. On the other hand, groups III-V received embelin (12.5, 25 and 50 mg/kg, P.O. respectively) while group VI received a standard dexamethasone (2.5 mg/kg, P.O.) for 15 days from day 27. Lung function parameters, including the respiratory rate, tidal volume and airflow rate were measured at the end of the experiment (day 42). The total and differential counts of leukocytes in the blood and bronchoalveolar fluid (BALF) were calculated. Th2-mediated serum pro-inflammatory cytokines such as interleukin (IL)-4, IL-5 and IL-13 levels were analyzed. At the end of the study protocol, the lung tissues were removed for a histopathology study. Additionally, a molecular docking simulation on embelin and standard dexamethasone was applied to support the in vivo findings.
RESULTS: Significant inhibition of eosinophils, neutrophils, lymphocytes and monocytes in the blood and the BALF was seen in the groups, which received embelin (25 and 50 mg/kg) and dexamethasone (2.5 mg/kg). Moreover, the lung function parameters were normalised by embelin (25 and 50 mg/kg) treatment significantly. The lung histopathological changes confirmed the protective effect of embelin against severe airway inflammation. The docking findings indicated good binding efficacy of embelin to IL-13.
CONCLUSION: Overall, our findings indicate that embelin can alleviate severe airway inflammation in OVA-LPS-induced model of allergic asthma occurring by suppression of Th2-mediated immune response. Due to its promising anti-asthmatic effect, it is recommended that embelin should be investigated in clinical trials against asthma. It should also be further explored against COVID-19 or COVID-like diseases due to its ameliorative effects on cytokines and immune cell infiltration.
Fulltext Poor sitting posture and a heavy schoolbag as contributors to musculoskeletal pain in children: an ergonomic school education intervention program

Syazwan A, Azhar MM, Anita A, Azizan H, Shaharuddin M, Hanafiah JM, et al.

J Pain Res, 2011;4:287-96.
PMID: 22003301 DOI: 10.2147/JPR.S22281

OBJECTIVES: The purpose of this study was to evaluate a multidisciplinary, interventional, ergonomic education program designed to reduce the risk of musculoskeletal problems by reducing schoolbag weight and correcting poor sitting posture.
METHODS: Data were collected twice before and twice following intervention using the Standardized Nordic Body Map Questionnaire, a rapid upper limb assessment for posture evaluation, and schoolbag weight measurement in children aged 8 and 11 years attending two schools within the central region of Malaysia.
RESULTS: Students who received the ergonomic intervention reported significant improvements in their sitting posture in a classroom environment and reduction of schoolbag weight as compared with the controls.
CONCLUSION: A single-session, early intervention, group ergonomics education program for children aged 8 and 11 years is appropriate and effective, and should be considered as a strategy to reduce musculoskeletal pain among schoolchildren in this age group.
KEYWORDS: assessment; awareness; education; ergonomic; intervention; musculoskeletal pain; school children
Fulltext Development of an indoor air quality checklist for risk assessment of indoor air pollutants by semiquantitative score in nonindustrial workplaces

Syazwan A, Rafee BM, Hafizan J, Azman A, Nizar A, Izwyn Z, et al.

Risk Manag Healthc Policy, 2012;5:17-23.
PMID: 22570579 DOI: 10.2147/RMHP.S26567

To meet the current diversified health needs in workplaces, especially in nonindustrial workplaces in developing countries, an indoor air quality (IAQ) component of a participatory occupational safety and health survey should be included.
Fulltext Analysis of indoor air pollutants checklist using environmetric technique for health risk assessment of sick building complaint in nonindustrial workplace

Syazwan A, Rafee BM, Juahir H, Azman A, Nizar A, Izwyn Z, et al.

Drug Healthc Patient Saf, 2012;4:107-26.
PMID: 23055779 DOI: 10.2147/DHPS.S33400

To analyze and characterize a multidisciplinary, integrated indoor air quality checklist for evaluating the health risk of building occupants in a nonindustrial workplace setting.